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Local Mechano-Dependent Calcium Influx Controls the Activity of Calcium-Dependent Potassium Channels of Big and Small Conductance in Human Lymphoma Cells
AbstractBurkitt’s lymphoma is an aggressive and fast-growing form of non-Hodgkin’s lymphoma with the highest invasive potential of all types of...
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The emerging role of Piezo1 channels in skeletal muscle physiology
Piezo1 channels are mechanically activated (MA) cation channels that are involved in sensing of various mechanical perturbations, such as membrane...
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Gastric mechanosensitive channel Piezo1 regulates ghrelin production and food intake
Ghrelin, produced mainly by gastric X/A-like cells, triggers a hunger signal to the central nervous system to stimulate appetite. It remains unclear...
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Contribution of mechanosensitive channels to osmoadaptation and ectoine excretion in Halomonas elongata
For osmoadaptation the halophilic bacterium Halomonas elongata synthesizes as its main compatible solute the aspartate derivative ectoine. H. elongata ...
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Chirality-induced Lineage Enforcement of Mechanosensitive Mesenchymal Stem Cells Across Germ Layer Boundaries
AbstractMesenchymal to epithelial transition (MET) is instrumental in embryogenesis, tissue repair, and wound healing while the epithelial to...
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Drosophila TMEM63 and mouse TMEM63A are lysosomal mechanosensory ion channels
Cells sense physical forces and convert them into electrical or chemical signals, a process known as mechanotransduction. Whereas extensive studies...
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Crowding-induced opening of the mechanosensitive Piezo1 channel in silico
Mechanosensitive Piezo1 channels are essential mechanotransduction proteins in eukaryotes. Their curved transmembrane domains, called arms, create a...
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Functional Activity of Sodium Channels ENaC in Human Endometrial Mesenchymal Stem Cells
Abstract—The work is aimed to reveal the functional activity of sodium channels ENaC in human endometrial mesenchymal stem cells (eMSC)....
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Role of adhesion forces in mechanosensitive channel gating in Staphylococcus aureus adhering to surfaces
Mechanosensitive channels in bacterial membranes open or close in response to environmental changes to allow transmembrane transport, including...
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Lipid–protein forces predict conformational changes in a mechanosensitive channel
The mechanosensitive TREK-2 potassium channel, a member of the K2P family, has essential physiological roles and is, therefore, a pharmaceutical...
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Piezo protein determines stem cell fate by transmitting mechanical signals
Piezo ion channel is a mechanosensitive protein on the cell membrane, which contains Piezo1 and Piezo2. Piezo channels are activated by mechanical...
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Dissecting cell membrane tension dynamics and its effect on Piezo1-mediated cellular mechanosensitivity using force-controlled nanopipettes
The dynamics of cellular membrane tension and its role in mechanosensing, which is the ability of cells to respond to physical stimuli, remain...
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Piezo1 mechanosensitive channels: what are they and why are they important
Mechanosensitive (MS) ion channels are integral membrane proteins which play a crucial role in fast signaling during mechanosensory transduction...
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Spatiotemporal modulation of nitric oxide and Notch signaling by hemodynamic-responsive Trpv4 is essential for ventricle regeneration
Zebrafish have a remarkable ability to regenerate injured hearts. Altered hemodynamic forces after larval ventricle ablation activate the endocardial...
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Transient receptor potential (TRP) channels mRNA transcripts in the lumbar intervertebral discs: biomarkers for inflammation, pain, disability, and clinical outcome
Transient receptor potential (TRP) channels are widely expressed cation channels that play an essential role in mediating Ca2+ homeostasis and are...
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Wireless neuromodulation in vitro and in vivo by intrinsic TRPC-mediated magnetomechanical stimulation
Various magnetic deep brain stimulation (DBS) methods have been develo** rapidly in the last decade for minimizing the invasiveness of DBS....
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2021 Nobel Prize for mechanosensory transduction
Written by someone who has worked in the mechanobiology field for close to 40 years, this commentary describes some historical background to the...
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Epithelial Mechanosensing at Cell-Cell Contacts and Tight Junctions
This chapter focuses on the mechanosensitive properties of epithelial tissues. Epithelia experience a range of mechanical forces arising both...
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Quantitative Live-Cell Ca2+ Imaging During Isotropic Cell Stretch
Cell viability of many cell types strongly relies on their ability to adjust to mechanical conditions and alterations. Cellular mechanisms for...
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Auxin- and pH-induced guttation in Phycomyces sporangiophores: relation between guttation and diminished elongation growth
Guttation, the formation of exudation water, is widespread among plants and fungi, yet the underlying mechanisms remain largely unknown. We describe...
