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An Integral View on Calcium Channels and Transporters Sha** Calcium and Exocytotic Signals in Chromaffin Cells
This chapter focuses on calcium movements and their impact on exocytosis in adrenal medullary chromaffin cells (CCs). Upon depolarization, Ca2+...
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Cholesterylation of Smoothened is a calcium-accelerated autoreaction involving an intramolecular ester intermediate
Hedgehog (Hh) is a morphogen that binds to its receptor Patched 1 and activates Smoothened (SMO), thereby governing embryonic development and...
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Reduced mitochondrial calcium uptake in macrophages is a major driver of inflammaging
Mitochondrial dysfunction is linked to age-associated inflammation or inflammaging, but underlying mechanisms are not understood. Analyses of 700...
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Two putative calcium-dependent protein kinases are involved in the regulation of sugarcane defense genes
Sugarcane is a primary sugar crop and an important source of bioenergy. Pathogens are the major factors affecting sugarcane yield and sugar content....
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NOX4-derived ROS are neuroprotective by balancing intracellular calcium stores
Hyperexcitability is associated with neuronal dysfunction, cellular death, and consequently neurodegeneration. Redox disbalance can contribute to...
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From Calcium Channels to New Therapeutics
An ultimate goal of biomedical research into calcium channels is to enable better treatment of disease, most prominently through the development of...
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Silencing of the T-type voltage-gated calcium channel α1 subunit by fungus-mediated RNAi altered the structure of F-actin and caused defective behaviors in Ditylenchus destructor
BackgroundT-type calcium channels, characterized as low-voltage activated (LVA) calcium channels, play crucial physiological roles across a wide...
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Ethanol Causes Cell Death and Neuronal Differentiation Defect During Initial Neurogenesis of the Neural Retina by Disrupting Calcium Signaling in Human Retinal Organoids
Fetal Alcohol Syndrome (FAS) affects a significant proportion, exceeding 90%, of afflicted children, leading to severe ocular aberrations such as...
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Pharmacology of Voltage-Gated Calcium Channels at Atomic Resolution
Voltage-gated calcium channels are evolutionarily related transmembrane signaling proteins that mediate calcium entry during action potentials and...
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Localized calcium transients in phragmoplast regulate cytokinesis of tobacco BY-2 cells
Key messagePlants exhibit a unique pattern of cytosolic Ca 2+ dynamics to correlate with microtubules to regulate cytokinesis, which significantly...
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Local and systemic mechanisms that control the hair follicle stem cell niche
Hair follicles are essential appendages of the mammalian skin, as hair performs vital functions of protection, thermoregulation and sensation. Hair...
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Calcium and Phosphate Ion Efflux from Cells: The Roles of Matrix Vesicles, Extracellular Vesicles, and Other Membrane-invested Transporters in Vertebrate Hard Tissue Mineralization
Based on studies of ion transport in a range of mineralizing vertebrate as well as invertebrate tissues, the chapter addresses the trafficking of...
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Influencing factors on ureolytic microbiologically induced calcium carbonate precipitation for biocementation
Microbiologically induced calcium carbonate precipitation (MICP) is a technique that has received a lot of attention in the field of geotechnology in...
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An inactivating human TRPC6 channel mutation without focal segmental glomerulosclerosis
Transient receptor potential cation channel-6 ( TRPC6 ) gene mutations cause familial focal segmental glomerulosclerosis (FSGS), which is inherited as...
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Lead and calcium crosstalk tempted acrosome damage and hyperpolarization of spermatozoa: signaling and ultra-structural evidences
BackgroundExposure of humans and animals to heavy metals is increasing day-by-day; thus, lead even today remains of significant public health...
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Voltage-Gated Calcium Channels and Migraine
Missense mutations in CACNA1A, the gene encoding the pore-forming subunit of the human voltage-gated CaV2.1 (P/Q-type calcium) channel, cause a rare...
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Molecular and physiological evidence of HvCaLB1 regulates calcium homeostasis and salt tolerance in Barley
The loss of crop productivity due to soil salinity is an increasing threat to agriculture worldwide. Calcium (Ca 2+ ) plays vital roles in...
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TRPV3-ANO1 interaction positively regulates wound healing in keratinocytes
Transient receptor potential vanilloid 3 (TRPV3) belongs to the TRP ion channel super family and functions as a nonselective cation channel that is...
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Calcium-Dependent Signaling in Cardiac Myocytes
Calcium (Ca) is a key regulator of cardiac function. Through interactions with various molecular binding partners, Ca controls both acute processes,...
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Splicing and Editing to Fine-Tune Activity of High Voltage-Activated Calcium Channels
The mRNA transcripts of voltage-gated calcium channels (VGCCs) are subjected to extensive alternative splicing giving rise to a plethora of channel...