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Nicotinate-curcumin improves NASH by inhibiting the AKR1B10/ACCα-mediated triglyceride synthesis
BackgroundNonalcoholic steatohepatitis (NASH) is a prevalent chronic liver condition. However, the potential therapeutic benefits and underlying...
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A New Approach to Release Insoluble Curcumin into DU-145 Human Prostate Cancer Cells Through Biodegradable Polymeric Nanocarriers with Apoptosis Induction and Metastasis Inhibition
AbstractObjective: Curcumin (C 21 H 20 O 6 , CUR) is the most abundant compound in turmeric (Curcuma longa), which had antioxidant, anti-cancer and...
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Transcription of human β-galactoside α2,6-sialyltransferase (hST6Gal I) is downregulated by curcumin through AMPK signaling in human colon carcinoma HCT116 cells
BackgroundIn this study, we observed that in human colon carcinoma HCT116 cells mRNA level of the human β-galactoside α2,6-sialyltransferase (hST6Gal...
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Effect of Resveratrol and Curcumin on Changes in Fatty Acid Composition and Oxidative Stress in Liver and Kidney Tissues of Rats Exposed to 7,12-Dimethylbenz[a]anthracene (DMBA)
AbstractThis study was conducted for the main purpose of evaluating the effect of resveratrol and curcumin on changes in fatty acid composition in...
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Impact of Curcumin on Hepatic Low-Density Lipoprotein Uptake
Elevated levels of plasma low-density lipoprotein cholesterol (LDL-C) are causally related to atherosclerotic cardiovascular disease. Enhancing the... -
Curcumin-rich curry consumption and life expectancy: Singapore longitudinal ageing study
The therapeutic potential of curcumin for many diseases are intensively investigated. However, real-world observational data documenting health and...
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Co-treatment with bone marrow-derived mesenchymal stem cells and curcumin improved angiogenesis in myocardium in a rat model of MI
BackgroundThe cardioprotective properties of mesenchymal stem cells and the therapeutic potential of curcumin (CUR) have been explored. Combining...
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Curcumin interferes with chitin synthesis in Aedes aegypti: a computational and experimental investigation
Throughout history, vector-borne diseases have consistently posed significant challenges to human health. Among the strategies for vector control,...
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pH/Temperature Responsive Curcumin-Loaded Micelle Nanoparticles Promote Functional Repair after Spinal Cord Injury in Rats via Modulation of Inflammation
Background:The formation of an inhibitory inflammatory microenvironment after spinal cord injury (SCI) remains a great challenge for nerve...
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Curcumin can improve spinal cord injury by inhibiting DNA methylation
Spinal cord injury (SCI) is a serious central nervous system disease. Traumatic SCI often causes persistent neurological deficits below the injury...
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The Role of Curcumin as an Anti-Aging Compound
It is claimed that delaying aging is more effective and less expensive than treating specific age-related disorders. Compounds that may postpone the... -
In vitro anticancer study of novel curcumin derivatives via targeting PI3K/Akt/p53 signaling pathway
Four new series of curcumin derivatives bearing NO-donating moiety were synthesized via etherification, nucleophilic substitution, and Knoevenagel...
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Delivery of curcumin within emulsome nanoparticles enhances the anti-cancer activity in androgen-dependent prostate cancer cell
BackgroundCurcumin, a dietary polyphenol isolated from turmeric, is a potent phytochemical possessing intrinsic anticancer activities against various...
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Synergistic anticancer effects of curcumin and crocin on human colorectal cancer cells
BackgroundCurcumin, a polyphenol compound derived from the Curcuma longa L, and crocin, a hydrophilic carotenoid from Crocus Sativus Linnaeus, are...
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Effects of Juglone and Curcumin Administration on Expression of FABP5 and FABP9 in MCF-7 and MDA-MB-231 Breast Cancer Cell Lines
Abstract —Among natural chemopreventive agents, polyphenol curcumin and naphthoquinone juglone, which has broad-spectrum anticancer activity, are...
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Harnessing the combined effect of antivirulence agent trans-chalcone with bactericidal curcumin against sortase A enzyme to tackle Gram-positive bacterial infections
Gram-positive bacteria are responsible for a wide range of infections in humans. In most Gram-positive bacteria, sortase A plays a significant role...
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A fabricated hydrogel of hyaluronic acid/curcumin shows super-activity to heal the bacterial infected wound
High risk of acute morbidities and even mortality from expanding the antibiotics resistant infectious wounds force indefinite efforts for development...
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The evaluation of chitosan hydrogel based curcumin effect on DNMT1, DNMT3A, DNMT3B, MEG3, HOTAIR gene expression in glioblastoma cell line
BackgroundCancer is one of the most important causes of death worldwide. Some types of cancer, including glioblastoma, with a high potential for...
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Nutritional and ameliorative effects of dietary curcumin and its nano-silica and nano-zeolite encapsulated forms on growth, biochemical and fatty acid profile of common carp (Cyprinus carpio)
The present study aimed to examine individual nutritional and ameliorative effects of silica nanoparticles (SiO 2 NPs) and natural zeolite...
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Olive oil nanoemulsion containing curcumin: antimicrobial agent against multidrug-resistant bacteria
AbstractThe present work aimed to develop, characterize, and evaluate the antibacterial and antibiofilm activity of two nanoemulsions (NEs)...