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Targeted and whole-genome sequencing reveal a north-south divide in P. falciparum drug resistance markers and genetic structure in Mozambique
Mozambique is one of the four African countries which account for over half of all malaria deaths worldwide, yet little is known about the parasite...
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Will This Drug Work for You?
People can respond differently to the same drug used to treat the same condition. Several reasons can account for the range of responses including...
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Diatretol, an α, α′-dioxo-diketopiperazine, is a potent in vitro and in vivo antimalarial
A fungal metabolite, diatretol, has shown to be a promising antimalarial agent. Diatretol displayed potent in vitro antiparasitic activity against...
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Modulating the antibacterial effect of the existing antibiotics along with repurposing drug metformin
Owing to the extensive prevalence of resistant bacteria to numerous antibiotic classes, antimicrobial resistance (AMR) poses a well-known hazard to...
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Artificial Intelligence and Machine Learning in Drug Discovery
The process of finding a medication lead starts with identifying the target of a certain disease, followed by hit identification, and lead...
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The Contribution of Artificial Intelligence to Drug Discovery: Current Progress and Prospects for the Future
The swift progress of artificial intelligence (AI) is fundamentally altering the terrain of drug discovery, carrying the substantial potential to...
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Isolation and identification of carotenoid-producing yeast and evaluation of antimalarial activity of the extracted carotenoid(s) against P. falciparum
Plasmodial resistance to a variety of plant-based antimalarial drugs has led toward the discovery of more effective antimalarial compounds having...
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First Insight into Drug Resistance Genetic Markers, Glucose-6-Phosphate Dehydrogenase and Phylogenetic Patterns of Misdiagnosed Plasmodium vivax Malaria in Far North Region, Cameroon
Plasmodium falciparum ( Pf ) is the predominant malaria species in Africa, but growing rates of non-falciparum species such as P. vivax ( Pv ) have been...
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Retinal Organoids: A Next-Generation Platform for High-Throughput Drug Discovery
Retinal diseases are leading causes of blindness globally. Develo** new drugs is of great significance for preventing vision loss. Current drug...
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Cuscuta reflexa Possess Potent Inhibitory Activity Against Human Malaria Parasite: An In Vitro and In Vivo Study
Drug resistance to practically all antimalarial drugs in use necessitate the development of new chemotherapeutics against malaria. In this aspect,...
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Retargeting azithromycin analogues to have dual-modality antimalarial activity
BackgroundResistance to front-line antimalarials (artemisinin combination therapies) is spreading, and development of new drug treatment strategies...
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Big Data in Drug Discovery
Drug discovery is a challenging and complicated process that requires decades to discover and develop a drug. This process can be streamlined and...
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Drug Design Methods to Regulate Protein–Protein Interactions
Inhibiting anomalous protein–protein interactions has led to the discovery of drugs (small molecules, precisely) that can inhibit such interactions...
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Artemisia annua L.: Comprehensive Review of Pharmacological Properties
Artemisia annua L. has been diagnosed as a potent medicinal herb and has been well documented in the historical pharmacopoeias of distinctive Asian...
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Enhancing drug property prediction with dual-channel transfer learning based on molecular fragment
BackgroundAccurate prediction of molecular property holds significance in contemporary drug discovery and medical research. Recent advances in...
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In silico investigation of falcipain-2 inhibition by hybrid benzimidazole-thiosemicarbazone antiplasmodial agents: A molecular docking, molecular dynamics simulation, and kinetics study
The emergence of artemisinin-resistant variants of Plasmodium falciparum necessitates the urgent search for novel antimalarial drugs. In this regard,...
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Microalgae and Cyanobacteria: A Potential Source for Drug Discovery Using Genome Mining Approach
Drug discovery has been one of the most widely studied areas of research in the field of science and technology; a new disease has been emerging...
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Enhancement of Natural Products in Plant in the Post-genomics Era: The New Era of Natural Drug Discovery
Natural products (NPs) remain an invaluable resource, serving as a promising pool for the discovery of structurally diverse scaffolds with various...
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HPTLC quantification of quercetin from leaf extracts of C. occidentalis L. and its inhibitory activity against protease enzyme of P. falciparum
Most of the therapeutically relevant antimalarial medications target the parasite during the blood stage of its life cycle. As a result, new...
