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Ceramide from sphingomyelin hydrolysis induces neuronal differentiation, whereas de novo ceramide synthesis and sphingomyelin hydrolysis initiate apoptosis after NGF withdrawal in PC12 Cells
BackgroundCeramide, important for both neuronal differentiation and dedifferentiation, resides in several membranes, is synthesized in the...
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Reversibility of hAT-MSCs phenotypic and metabolic changes after exposure to and withdrawal from HCC-conditioned medium through regulation of the ROS/MAPK/HIF-1α signaling pathway
BackgroundMesenchymal stem cells (MSCs) play an important role in tumor progression; concomitantly, MSCs also undergo profound changes in the tumor...
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The Withdrawal of God and Humanity as Co-creator in Hans Jonas’ Cosmogonic Conjecture
Interiority, reason, freedom, and the transcendent are cosmic figures that are studied from cosmology and about whose first cause Hans Jonas...
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Application of gabapentinoids and novel compounds for the treatment of benzodiazepine dependence: the glutamatergic model
BackgroundCurrent approaches for managing benzodiazepine (BZD) withdrawal symptoms are daunting for clinicians and patients, warranting novel...
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Distinguishing the contribution of nitrogen fertilizer and native soil nitrogen to young apple trees
The nitrogen (N) demand–supply is crucial for optimizing nutrient management in orchards. However, some knowledge gaps remain regarding the exact...
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Selective activation of AKAP150/TRPV1 in ventrolateral periaqueductal gray GABAergic neurons facilitates conditioned place aversion in male mice
Aversion refers to feelings of strong dislike or avoidance toward particular stimuli or situations. Aversion can be caused by pain stimuli and has a...
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EphA1 aggravates neuropathic pain by activating CXCR4/RhoA/ROCK2 pathway in mice
Neuropathic pain is a refractory disease with limited treatment options due to its complex mechanisms. Whereas erythropoietin-producing hepatocyte A1...
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Hypolimnetic withdrawal as a lake restoration technique: determination of feasibility and continued benefits
The withdrawal of hypolimnetic water enriched with nutrients and reduced substances has been used as a lake restoration technique (hypolimnetic...
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Long noncoding RNA small nucleolar RNA host gene 5 facilitates neuropathic pain in spinal nerve injury by promoting SCN9A expression via CDK9
This study aims to explore the functions and mechanisms of long noncoding RNA small nucleolar RNA host gene 5 (SNHG5) in chronic constriction injury...
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Continuous immunosuppression is required for suppressing immune responses to xenografts in non-human primate brains
Continuous immunosuppression has been widely used in xenografts into non-human primate brains. However, how immune responses change after...
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Assessing aerobic rice systems for saving irrigation water and paddy yield at regional scale
Aerobic rice cultivation has been proposed as a water-saving option. Regional assessments are necessary to quantify its importance as such an option...
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Towards circular economy by valorization of waste upholstery textile fibers in fibrous wood-based composites production
The aim of the research was to utilize textile waste by adding upholstery fabric fibers with different content (0, 5, 10, and 20% by weight referred...
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Amino acid intake strategies define pluripotent cell states
Mammalian preimplantation development is associated with marked metabolic robustness, and embryos can develop under a wide variety of nutrient...
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Anterior cingulate cross-hemispheric inhibition via the claustrum resolves painful sensory conflict
The anterior cingulate cortex (ACC) responds to noxious and innocuous sensory inputs, and integrates them to coordinate appropriate behavioral...
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Electroacupuncture inhibits dendritic spine remodeling through the srGAP3-Rac1 signaling pathway in rats with SNL
Previous studies have shown that peripheral nerve injury can lead to abnormal dendritic spine remodeling in spinal dorsal horn neurons. Inhibition of...
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Molecular mechanisms of morphine tolerance and dependence; novel insights and future perspectives
Drug addiction is a devastating condition that poses a serious burden on the society. The use of some drugs like morphine for their tremendous...
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Tailored therapeutic decision of rheumatoid arthritis using proteomic strategies: how to start and when to stop?
Unpredictable treatment responses have been an obstacle for the successful management of rheumatoid arthritis. Although numerous serum proteins have...
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Bending fatigue performance of L-shaped stapled one-side two-gusset-plate upholstered furniture joints in oriented strandboard
The stapled, one-side, two-gusset-plate system is a standard method for joining two structural members such as front stump and front rail in...
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Activation of the glutamatergic cingulate cortical-cortical connection facilitates pain in adult mice
The brain consists of the left and right cerebral hemispheres and both are connected by callosal projections. Less is known about the basic mechanism...
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Falling Damage Behavior Analysis and Degree Prediction for Wooden Pallet Based on Piezoelectric Effect and Acoustic Emission
Wooden pallets can straightforwardly sustain fractures during storage and transportation. This shortens their service life. To minimize the economic...
