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Strategies for synthesis of 1,2,4-triazole-containing scaffolds using 3-amino-1,2,4-triazole
1,2,4-Triazole-containing scaffolds are unique heterocyclic compounds present in an array of pharmaceuticals and biologically important compounds...
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Design, synthesis, X-ray crystal structure, and antimicrobial evaluation of novel quinazolinone derivatives containing the 1,2,4-triazole Schiff base moiety and an isopropanol linker
A series of novel quinazolinone derivatives ( E1−E31 ) containing the 1,2,4-triazole Schiff base moiety and an isopropanol linker were designed,...
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Synthesis of Novel 1,2,3-Triazole Derivatives of Tolbutamide and Evaluation of Their Antibacterial, Antioxidant, and DPP-4 Inhibitory Activity
AbstractA series of new 1,2,3-triazole derivatives of tolbutamide analogues have been synthesized in a simple and effective way in high yields to...
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Chemical Synthesis of Triazole-Derived Suppressors of Strigolactone Functions
Triazole is a five-membered heteroring consists of two carbon atoms and three nitrogen atoms and exhibits a wide range of biological activities. The...
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Imidazole-Thiazolidine-2,4-dione Conjugated 1,2,3-Triazole Derivatives as Tubulin Aiming Antiproliferative Agents
AbstractA new series of imidazole-thiazolidine-2,4-dione coupled 1,2,3-triazoles ( VIIa–VIIm ) were synthesized using Knoevengal condensation and...
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Synthesis and Anti-Tubercular (Tb) Evaluation of Bis[4-Ethylidineamino[1,2,4]Triazole-3-Thiol] Tethered by 1,4-Dihydropyridine
AbstractA new series of 5,5'-(2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-diyl)bis[4-(ethylideneamino)-4 H -[1,2,4]-triazole-3-thiol) was...
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Facile synthesis, spectroscopic evaluation and antimicrobial screening of metal endowed triazole compounds
The scientific interest in develo** new complexes as inhibitors of bacterial biofilm related infections is constantly rising. The present work...
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Mesoporous epoxidized soybean oil-supported copper-based magnetic nanocatalyst and amberlite-supported azide as a green and efficient catalytic system for 1,2,3-triazole synthesis
A new green mesoporous magnetically heterogeneous catalyst was prepared by the copper immobilization onto magnetic epoxidized soybean oil as a nano...
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Urea-thiazole/benzothiazole hybrids with a triazole linker: synthesis, antimicrobial potential, pharmacokinetic profile and in silico mechanistic studies
Some urea-thiazole/benzothiazole hybrids with a triazole linker were synthesized via Cu(I)-catalysed click reaction. After successfully analysed by...
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Novel (Z)/(E)-1,2,4-triazole derivatives containing oxime ether moiety as potential ergosterol biosynthesis inhibitors: design, preparation, antifungal evaluation, and molecular docking
Inspired by the highly effective and broad-spectrum antifungal activity of ergosterol biosynthesis inhibitions, a series of novel 1,2,4-triazole...
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Design and synthesis of phenoxymethybenzoimidazole incorporating different aryl thiazole-triazole acetamide derivatives as α-glycosidase inhibitors
A novel series of phenoxymethybenzoimidazole derivatives ( 9a-n ) were rationally designed, synthesized, and evaluated for their α-glycosidase...
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Cu(I)-Promoted Regioselective Synthesis of Some New Benzimidazole-1,2,3-Triazole Frameworks as In Vitro Anticancer Agents
AbstractThe regioselective synthesis of twelve new benzimidazole-1,2,3-triazole hybrids through the Cu(I)-catalyzed 1,3-dipolar cycloaddition...
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Synthesis of fish scale derived hydroxyapatite silica propyl bis aminoethoxy ethane cuprous complex (HASPBAEECC) as a novel hybrid nano-catalyst for highly efficient synthesis of new benzimidazole-1,2,3-triazole hybrid analogues as antifungal agents
AbstractThe preparation, characterization and application of hydroxyapatite silica propyl bis aminoethoxy ethane cuprous complex (HASPBAEECC) as a...
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Synthesis of 1,2,3,triazole modified analogues of hydrochlorothiazide via click chemistry approach and in-vitro α-glucosidase enzyme inhibition studies
The current study was aimed to discover potent inhibitors of α-glucosidase enzyme. A 25 membered library of new 1,2,3-triazole derivatives of...
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Synthesis and Anti-Proliferative Activity of New Acridinyl and Benzothiazolyl-Based Triazole Glycosides via Click Cycloaddition and Their Tetrazolyl Analogs
AbstractNovel acridine and benzothiazole substituted 1,2,3-triazole glycosides were synthesized by using Cu(I)-Catalyzed Azide-Alkyne Cycloaddition...
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Synthesis and insecticidal activity of novel 1,2,4-triazole derivatives containing trifluoroacetyl moieties
A series of compounds containing trifluoroacetyl groups were synthesized, and their insecticidal activity against Nilaparvata lugens and Aphis...
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New ursolic acid derivatives bearing 1,2,3-triazole moieties: design, synthesis and anti-inflammatory activity in vitro and in vivo
AbstractIn order to discover novel anti-inflammatory agents, three series of compounds obtained by appending 1,2,3-triazole moieties on ursolic acid...
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Synthesis, In-Silico Molecular Docking Studies, and In-Vitro Antimicrobial Evaluation of Isatin Scaffolds bearing 1, 2, 3-Triazoles using Click Chemistry
Bacterial infections continue to present a formidable challenge to human health, prompting intensified research efforts towards the development of...
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Simultaneous ultrasound- and microwave-assisted one-pot ‘click’ synthesis of 3-formyl-indole clubbed 1,2,3-triazole derivatives and their biological evaluation
An environment friendly, high yielding, promising one-pot protocol for the click reaction of N -propargyl-3-formylindole 2(a–b), chloroacetic...
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On-DNA-1,2,3-Triazole Formation via Click Reaction
Copper-catalyzed azide-alkyne cycloaddition (CuAAC) provides a simple and convenient strategy to synthesize diverse 1,2,3-triazoles for drug...