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RNA structure profiling at single-cell resolution reveals new determinants of cell identity
RNA structure is critical for multiple steps in gene regulation. However, how the structures of transcripts differ both within and between individual...
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Multimodal chromatin profiling using nanobody-based single-cell CUT&Tag
Probing histone modifications at a single-cell level in thousands of cells has been enabled by technologies such as single-cell CUT&Tag. Here we...
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Single-cell profiling to explore pancreatic cancer heterogeneity, plasticity and response to therapy
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer entity characterized by a heterogeneous genetic landscape and an immunosuppressive...
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De novo detection of somatic mutations in high-throughput single-cell profiling data sets
Characterization of somatic mutations at single-cell resolution is essential to study cancer evolution, clonal mosaicism and cell plasticity. Here,...
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Single-cell Profiling of Reprogrammed Human Neural Stem Cells Unveils High Similarity to Neural Progenitors in the Develo** Central Nervous System
BackgroundSimilar to induced pluripotent cells (iPSCs), induced neural stem cells (iNSCs) can be directly converted from human somatic cells such as...
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Multiplex profiling of developmental cis-regulatory elements with quantitative single-cell expression reporters
The inability to scalably and precisely measure the activity of developmental cis -regulatory elements (CREs) in multicellular systems is a bottleneck...
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Profiling human brain vascular cells using single-cell transcriptomics and organoids
Angiogenesis and neurogenesis are functionally interconnected during brain development. However, the study of the vasculature has trailed other brain...
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All-optical voltage imaging-guided postsynaptic single-cell transcriptome profiling with Voltage-Seq
Neuronal pathways recruit large postsynaptic populations and maintain connections via distinct postsynaptic response types (PRTs). Until recently,...
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Single-cell molecular profiling using ex vivo functional readouts fuels precision oncology in glioblastoma
BackgroundFunctional profiling of freshly isolated glioblastoma (GBM) cells is being evaluated as a next-generation method for precision oncology....
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Single Cell Atlas: a single-cell multi-omics human cell encyclopedia
Single-cell sequencing datasets are key in biology and medicine for unraveling insights into heterogeneous cell populations with unprecedented...
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Single-cell multi-omics profiling links dynamic DNA methylation to cell fate decisions during mouse early organogenesis
BackgroundPerturbation of DNA methyltransferases (DNMTs) and of the active DNA demethylation pathway via ten-eleven translocation (TET)...
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Pairing of single-cell RNA analysis and T cell antigen receptor profiling indicates breakdown of T cell tolerance checkpoints in atherosclerosis
Atherosclerotic plaques form in the inner layer of arteries triggering heart attacks and strokes. Although T cells have been detected in...
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Application of Single-Cell Sequencing on Stem Cell Research
The variation and heterogeneity within cells are the fundamental features of stem cells. Each tissue has a resident stem cell niche compartmentalized...
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Fast and flexible profiling of chromatin accessibility and total RNA expression in single nuclei using Microwell-seq3
Single cell chromatin accessibility profiling and transcriptome sequencing are the most widely used technologies for single-cell genomics. Here, we...
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Profiling Cellular Ecosystems at Single-Cell Resolution and at Scale with EcoTyper
Tissues are composed of diverse cell types and cellular states that organize into distinct ecosystems with specialized functions. EcoTyper is a...
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Optimizing the Cell Painting assay for image-based profiling
In image-based profiling, software extracts thousands of morphological features of cells from multi-channel fluorescence microscopy images, yielding...
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Single-cell profiling reveals transcriptome dynamics during bovine oocyte growth
BackgroundMammalian follicle development is characterized by extensive changes in morphology, endocrine responsiveness, and function, providing the...
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Single-cell transcriptomic profiling unveils insights into ovarian fibrosis in obese mice
BackgroundAdiposity profoundly impacts reproductive health in both humans and animals. However, the precise subpopulations contributing to...
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Single-Cell RNAseq Clustering
Single-cell RNA sequencing (scRNA-seq) allows the creation of large collections of individual cells transcriptome. Unsupervised clustering is an...