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The therapeutic potential of neurofibromin signaling pathways and binding partners
Neurofibromin controls many cell processes, such as growth, learning, and memory. If neurofibromin is not working properly, it can lead to health...
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Signaling Pathways in Trans-differentiation of Mesenchymal Stem Cells: Recent Advances
Mesenchymal stem cells are a group of multipotent cells that can be induced to differentiate into other cell types. The cells fate is decided by...
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Phenolics Biosynthesis, Targets, and Signaling Pathways in Ameliorating Oxidative Stress in Plants
In plant cells, acquaintance to drought, salinity, temperature excesses, air pollutants, heavy metals, ultraviolet radiations, and pathogens outcomes...
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Discrete Logic Modeling of Cell Signaling Pathways
Cell signaling pathways often crosstalk generating complex biological behaviors observed in different cellular contexts. Frequently, laboratory...
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Multiple pathways mediate chloroplast singlet oxygen stress signaling
Key messageChloroplast singlet oxygen initiates multiple pathways to control chloroplast degradation, cell death, and nuclear gene expression.
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Role of calcium in regulating key steps in phytochrome-induced signaling pathways
A major focus in the field of signal transduction pathways in plants has been the role of calcium ions in mediating diverse sensory responses. Among...
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Executable models of immune signaling pathways in HIV-associated atherosclerosis
Atherosclerosis (AS)-associated cardiovascular disease is an important cause of mortality in an aging population of people living with HIV (PLWH)....
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The global integrative network: integration of signaling and metabolic pathways
The crosstalk between signaling and metabolic pathways has been known to play key roles in human diseases and plant biological processes. The...
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Complex and pleiotropic signaling pathways regulated by the secreted protein augurin
The secreted protein augurin, the product of the tumor suppressor gene Ecrg4 , has been identified as a peptide hormone in the human proteome in 2007....
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Sorcin promotes migration in cancer and regulates the EGF-dependent EGFR signaling pathways
The epidermal growth factor receptor (EGFR) is one of the main tumor drivers and is an important therapeutic target for many cancers. Calcium is...
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Signaling Pathways that Regulate Macropinocytosis in Mammalian Cells
Macropinocytosis is an evolutionarily conserved endocytic pathway that mediates non-selective uptake of extracellular fluid in bulk. Macropinocytosis...
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Role of oxidative stress and inflammation-related signaling pathways in doxorubicin-induced cardiomyopathy
Doxorubicin (DOX) is a powerful and commonly used chemotherapeutic drug, used alone or in combination in a variety of cancers, while it has been...
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Plant Adaptation to Abiotic Stress: From Signaling Pathways and Microbiomes to Molecular Mechanisms
The book “Plant Adaptation to Abiotic Stress: From Signaling Pathways and Microbiomes to Molecular Mechanisms” comprehensively examines abiotic...
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Signaling Pathways of Gasotransmitters in Heavy Metal Stress Mitigation
Expanding population, industrialization and inadequate agricultural practices are complementing the ongoing environmental challenges and abiotic...
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Characterization of gastric cancer-stimulated signaling pathways and function of CTGF in cancer-associated fibroblasts
BackgroundCancer-associated fibroblasts (CAFs) are key components of the tumor microenvironment (TME) that play an important role in cancer...
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The Role of Plant Defense Signaling Pathways in Phytoplasma-Infected and Uninfected Aster Leafhoppers’ Oviposition, Development, and Settling Behavior
In plant-microbe-insect systems, plant-mediated responses involve the regulation and interactions of plant defense signaling pathways of...
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Resolving Crosstalk Between Signaling Pathways Using Mathematical Modeling and Time-Resolved Single Cell Data
Crosstalk between signaling pathways can modulate the cellular response to stimuli and is therefore an important part of signal transduction. For a...
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Deficiency of ADAR2 ameliorates metabolic-associated fatty liver disease via AMPK signaling pathways in obese mice
Non-alcoholic fatty liver disease (NAFLD) is a chronic disease caused by hepatic steatosis. Adenosine deaminases acting on RNA (ADARs) catalyze...
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CXCL5 promotes tumorigenesis and angiogenesis of glioblastoma via JAK-STAT/NF-κb signaling pathways
BackgroundThe tumor microenvironment contains chemokines that play a crucial role in various processes, such as tumorigenesis, inflammation, and...
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Sugarcane ScOPR1 gene enhances plant disease resistance through the modulation of hormonal signaling pathways
Key messageTransgenic plants stably overexpressing ScOPR1 gene enhanced disease resistance by increasing the accumulation of JA, SA, and GST, as...
