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Monitoring Nuclease Activity by X-Ray Scattering Interferometry Using Gold Nanoparticle-Conjugated DNA
The biologically critical, exquisite specificity and efficiency of nucleases, such as those acting in DNA repair and replication, often emerge in the...
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Structural basis for the ligand promiscuity of the neofunctionalized, carotenoid-binding fasciclin domain protein AstaP
Fasciclins (FAS1) are ancient adhesion protein domains with no common small ligand binding reported. A unique microalgal FAS1-containing astaxanthin...
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SARS-CoV-2 proteins structural studies using synchrotron radiation
In the process of the development of structural biology, both the size and the complexity of the determined macromolecular structures have grown...
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ZBP1 condensate formation synergizes Z-NAs recognition and signal transduction
Z-DNA binding protein 1 (ZBP1) is a crucial player in the intracellular recognition of Z-form nucleic acids (Z-NAs) through its Zαβ domain,...
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Changes in the Structure of Potato Virus A Virions after Limited in situ Proteolysis According to Tritium Labeling Data and Computer Simulation
AbstractCoat proteins (CP) of the potato virus A virions (PVA) contain partially disordered N-terminal domains, which are necessary for performing...
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A template wizard for the cocreation of machine-readable data-reporting to harmonize the evaluation of (nano)materials
Making research data findable, accessible, interoperable and reusable (FAIR) is typically hampered by a lack of skills in technical aspects of data...
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Structural insights of the elongation factor EF-Tu complexes in protein translation of Mycobacterium tuberculosis
Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) is the second-deadliest infectious disease worldwide. Emerging evidence shows that the...
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The study of physico-mechanical properties of SiO2-impregnated wood under dry and saturated conditions
This research has demonstrated that SiO 2 impregnation under high vacuum pressure of − 90 kPa can significantly reduce porosity by almost 10%, and...
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The Structure of the Potato Virus A Particles Elucidated by Small Angle X-Ray Scattering and Complementary Techniques
AbstractPotato virus A (PVA) protein coat contains on its surface partially unstructured N-terminal domain of the viral coat protein (CP), whose...
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Strong non-ideality effects at low protein concentrations: considerations for elongated proteins
A recent investigation was aimed at obtaining structural information on a highly extended protein via SEC-MALS-SAXS. Significantly broadened elution...
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Dynamics and structural changes of calmodulin upon interaction with the antagonist calmidazolium
BackgroundCalmodulin (CaM) is an evolutionarily conserved eukaryotic multifunctional protein that functions as the major sensor of intracellular...
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Biochemical characterization and low-resolution SAXS shape of a novel GH11 exo-1,4-β-xylanase identified in a microbial consortium
Biotechnologies that aim to produce renewable fuels, chemicals, and bioproducts from residual ligno(hemi)cellulosic biomass mostly rely on enzymatic...
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Structural Analyses of Intrinsically Disordered Proteins by Small-Angle X-Ray Scattering
Small-angle X-ray scattering (SAXS) is a low-resolution method for the structural characterization of biological macromolecules in solution....
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A morpheein equilibrium regulates catalysis in phosphoserine phosphatase SerB2 from Mycobacterium tuberculosis
Mycobacterium tuberculosis phosphoserine phosphatase Mt SerB2 is of interest as a new antituberculosis target due to its essential metabolic role in...
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X-Ray Crystallography for Macromolecular Complexes
X-ray crystallography has for most of the last century been the standard technique to determine the high-resolution structure of biological...
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Pre- and Post-publication Verification for Reproducible Data Mining in Macromolecular Crystallography
Like an article narrative is deemed by an editor and referees to be worthy of being a version of record on acceptance as a publication, so must the...
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Structure of human DPPA3 bound to the UHRF1 PHD finger reveals its functional and structural differences from mouse DPPA3
DNA methylation maintenance is essential for cell fate inheritance. In differentiated cells, this involves orchestrated actions of DNMT1 and UHRF1....
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