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Efficient differentiation of human embryonic stem cells to retinal pigment epithelium under defined conditions
AbstractAge-related macular degeneration (AMD) is a highly prevalent form of blindness caused by loss death of cells of the retinal pigment...
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Targeting senescent retinal pigment epithelial cells facilitates retinal regeneration in mouse models of age-related macular degeneration
Although age-related macular degeneration (AMD) is a multifactorial disorder with angiogenic, immune, and inflammatory components, the most common...
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Sodium iodate induces ferroptosis in human retinal pigment epithelium ARPE-19 cells
Sodium iodate (SI) is a widely used oxidant for generating retinal degeneration models by inducing the death of retinal pigment epithelium (RPE)...
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Towards Stem/Progenitor Cell-Based Therapies for Retinal Degeneration
Retinal degeneration (RD) is a leading cause of blindness worldwide and includes conditions such as retinitis pigmentosa (RP), age-related macular...
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Cell-based Therapies for Corneal and Retinal Disorders
Maintenance of the visual function is the desired outcome of ophthalmologic therapies. The shortcomings of the current treatment options, like...
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Molecular Strategies for Transdifferentiation of Retinal Pigment Epithelial Cells in Amphibians and Mammals In Vivo
AbstractRetinal pigment epithelium (RPE) is a source of cells for retinal regeneration in amphibians in vivo and the development of retinal diseases...
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Factors influencing mesenchymal stromal cells in in vitro cellular models to study retinal pigment epithelial cell rescue
Mesenchymal stromal cells (MSC) stop or slow retinal pigment epithelium (RPE) and neuroretina (NR) degeneration by paracrine activity in oxidative...
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APOB100 transgenic mice exemplify how the systemic circulation content may affect the retina without altering retinal cholesterol input
Apolipoprotein B (APOB) is a constituent of unique lipoprotein particles (LPPs) produced in the retinal pigment epithelium (RPE), which separates the...
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New insights into the retinal microstructure-diurnal activity relationship in the African five-lined skink (Trachylepis quinquetaeniata) (Lichtenstein, 1823)
BackgroundThe retinae of diurnal vertebrates have characteristics. Most lizards are strictly diurnal, and their retinal morphology is still unknown.
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Reprogramming of Differentiated Mammalian and Human Retinal Pigment Epithelium: Current Achievements and Prospects
AbstractImpairment of the homeostatic and functional integrity of the retina and retinal pigment epithelium (RPE) is the main cause of some...
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Inhibiting HIF-1 signaling alleviates HTRA1-induced RPE senescence in retinal degeneration
BackgroundAge-related macular degeneration (AMD), characterized by the degeneration of retinal pigment epithelium (RPE) and photoreceptors, is the...
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Modeling of mitochondrial bioenergetics and autophagy impairment in MELAS-mutant iPSC-derived retinal pigment epithelial cells
BackgroundMitochondrial dysfunction and mitochondrial DNA (mtDNA) damage in the retinal pigment epithelium (RPE) have been implicated in the...
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IL-4 induces reparative phenotype of RPE cells and protects against retinal neurodegeneration via Nrf2 activation
Retinal degeneration is a kind of neurodegeneration characterized by progressive neuronal death and dysfunction of retinal pigment epithelium (RPE)...
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Effect of space flight on the behavior of human retinal pigment epithelial ARPE-19 cells and evaluation of coenzyme Q10 treatment
Astronauts on board the International Space Station (ISS) are exposed to the damaging effects of microgravity and cosmic radiation. One of the most...
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Mdm1 ablation results in retinal degeneration by specific intraflagellar transport defects of photoreceptor cells
Mouse double minute 1 ( Mdm1 ) might be involved in the function and structure of centrioles and age-related retinal degeneration. However, the...
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New Perspectives in Stem Cell Transplantation and Associated Therapies to Treat Retinal Diseases: From Gene Editing to 3D Bioprinting
Inherited and non-inherited retinopathies can affect distinct cell types, leading to progressive cell death and visual loss. In the last years, new...
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Retinal Organoids: A Next-Generation Platform for High-Throughput Drug Discovery
Retinal diseases are leading causes of blindness globally. Develo** new drugs is of great significance for preventing vision loss. Current drug...
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PACAP is Protective Against Cellular Stress in Retinal Pigment Epithelial Cells
The integrity of the innermost, pigment epithelial layer of the retina is crucial for the photoreceptor survival and for maintaining the outer...
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Therapeutic Potential of Oral-Derived Mesenchymal Stem Cells in Retinal Repair
The retina has restricted regeneration ability to recover injured cell layer because of reduced production of neurotrophic factors and increased...
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Unveiling the role of CaMKII in retinal degeneration: from biological mechanism to therapeutic strategies
Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) is a family of broad substrate specificity serine (Ser)/threonine (Thr) protein kinases that...
