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PARP1 allows proper telomere replication through TRF1 poly (ADP-ribosyl)ation and helicase recruitment
Telomeres are nucleoprotein structures at eukaryotic chromosome termini. Their stability is preserved by a six-protein complex named shelterin. Among...
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miR-28-based combination therapy impairs aggressive B cell lymphoma growth by rewiring DNA replication
Diffuse large B cell lymphoma (DLBCL) is the most common aggressive B cell lymphoma and accounts for nearly 40% of cases of B cell non-Hodgkin...
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Quantifying DNA replication speeds in single cells by scEdU-seq
In a human cell, thousands of replication forks simultaneously coordinate duplication of the entire genome. The rate at which this process occurs...
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FAAP100 is required for the resolution of transcription-replication conflicts in primordial germ cells
BackgroundThe maintenance of genome stability in primordial germ cells (PGCs) is crucial for the faithful transmission of genetic information and the...
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The Fork Protection Complex: A Regulatory Hub at the Head of the Replisome
As well as accurately duplicating DNA, the eukaryotic replisome performs a variety of other crucial tasks to maintain genomic stability. For example,...
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The Roles of Chromatin Remodelling Factors in Replication
Dynamic changes of chromatin structure control DNA-dependent events, including DNA replication. Along with DNA, chromatin organization must be...
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TOF1 and RRM3 reveal a link between gene silencing and the pausing of replication forks
Eukaryotic DNA replication is accompanied by the disassembly and reassembly of nucleosomes and the transmission of epigenetic marks to the newly...
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Quantity and quality of minichromosome maintenance protein complexes couple replication licensing to genome integrity
Accurate and complete replication of genetic information is a fundamental process of every cell division. The replication licensing is the first...
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Mouse Slfn8 and Slfn9 genes complement human cells lacking SLFN11 during the replication stress response
The Schlafen (SLFN)11 gene has been implicated in various biological processes such as suppression of HIV replication, replication stress response,...
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Checkpoint functions of RecQ helicases at perturbed DNA replication fork
DNA replication checkpoint is a cell signaling pathway that is activated in response to perturbed replication. Although it is crucial for maintaining...
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Single-Cell Analysis of Histone Acetylation Dynamics at Replication Forks Using PLA and SIRF
Genome integrity is constantly challenged by various processes including DNA damage, structured DNA, transcription, and DNA-protein crosslinks....
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Rif1 restrains the rate of replication origin firing in Xenopus laevis
Metazoan genomes are duplicated by the coordinated activation of clusters of replication origins at different times during S phase, but the...
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Unwinding of a eukaryotic origin of replication visualized by cryo-EM
To prevent detrimental chromosome re-replication, DNA loading of a double hexamer of the minichromosome maintenance (MCM) replicative helicase is...
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Fanconi anemia proteins participate in a break-induced-replication-like pathway to counter replication stress
Fanconi anemia (FA) is a devastating hereditary disease characterized by bone marrow failure (BMF) and acute myeloid leukemia (AML). As FA-deficient...
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Nuclear F-actin counteracts nuclear deformation and promotes fork repair during replication stress
Filamentous actin (F-actin) provides cells with mechanical support and promotes the mobility of intracellular structures. Although F-actin is...
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Mistimed origin licensing and activation stabilize common fragile sites under tight DNA-replication checkpoint activation
Genome integrity requires replication to be completed before chromosome segregation. The DNA-replication checkpoint (DRC) contributes to this...
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NAD+ regulates nucleotide metabolism and genomic DNA replication
The intricate orchestration of enzymatic activities involving nicotinamide adenine dinucleotide (NAD + ) is essential for maintaining metabolic...
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p53 at the crossroad of DNA replication and ribosome biogenesis stress pathways
Despite several decades of intense research focused on understanding function(s) and disease-associated malfunction of p53, there is no sign of any...
