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Metabolite Profiling of Alectryon Tomentosus Leaf Extract via GC/MS Analysis and Its Renal Protective Effect
Alectryon is a genus of trees in the family Sapindaceae that occurs in the rainforests of Australia and vast areas of Asian continent. In the present...
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Toxicological insight of magnetite nanogel: neuro-ethological, hepato-renal, antioxidant, and histopathological traits in Clarias gariepinus
Assessment of acute toxicity of magnetic nanogel (MNG) is crucial to conclude the safe applicable dose and to warrant its application in aquaculture....
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The Regenerative Potential of Human Adult Renal Stem/Progenitor Cells
The human adult renal stem/progenitor cells (ARPCs) play a role in renal regeneration in two ways: by differentiating directly or by secreting...
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Review of Zinc Oxide Nanoparticles: Toxicokinetics, Tissue Distribution for Various Exposure Routes, Toxicological Effects, Toxicity Mechanism in Mammals, and an Approach for Toxicity Reduction
Zinc oxide (ZnO) nanoparticles (NPs) are widely used as a sunscreen, antibacterial agent, dietary supplement, food additive, and semiconductor...
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Hepatoprotective Effect of Moringa Oil on Rats under Fungicide Toxicity
AbstractThe present study is designed to evaluate whether pretreatment with moringa would have a protective effect on thioacetamide (TAA)-induced...
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Levilactobacillus brevis MZ384011 and Levilactobacillus brevis MW362779 can mitigate lead induced hepato-renal damage by regulating visceral dispersion and fecal excretion
Heavy metal pollution is a global issue. Current study provides evidence on Pb toxicity ameliorative potential and safe nature of Levilactobacillus...
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The Footprints of Mitochondrial Fission and Apoptosis in Fluoride-Induced Renal Dysfunction
Fluoride (F) is widely distributed in the environment and poses serious health risks to humans and animals. Although a good body of literature...
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Renal macrophages and NLRP3 inflammasomes in kidney diseases and therapeutics
Macrophages are exceptionally diversified cell types and perform unique features and functions when exposed to different stimuli within the specific...
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Long-term viable chimeric nephrons generated from progenitor cells are a reliable model in cisplatin-induced toxicity
Kidney organoids have shown promise as evaluation tools, but their in vitro maturity remains limited. Transplantation into adult mice has aided in...
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Metformin potentiates nephrotoxicity by promoting NETosis in response to renal ferroptosis
Given the rapidly aging population, aging-related diseases are becoming an excessive burden on the global healthcare system. Metformin has been shown...
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Targeted changes in blood lipids improves fibrosis in renal allografts
BackgroundChronic interstitial fibrosis is the primary barrier against the long-term survival of transplanted kidneys. Extending the lifespan of...
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Modeling drug-induced mitochondrial toxicity with human primary cardiomyocytes
Mitochondrial toxicity induced by therapeutic drugs is a major contributor for cardiotoxicity, posing a serious threat to pharmaceutical industries...
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Reversal Effects of Royal Jelly and Propolis Against Cadmium-Induced Hepatorenal Toxicity in Rats
Heavy metal toxicity is an exponentially growing health problem. In this study, we aimed to assess the protective properties of propolis and royal...
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Bioproduction of yeast single cell oil with acute oral toxicity study intended for edible oil application
Human nutrition and health rely on edible oils. Global demand for edible oils is expanding, necessitating the discovery of new natural oil sources...
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Hepatorenal Toxicity of Inorganic Arsenic in White Pekin Ducks and Its Amelioration by Using Ginger
The toxic metalloid arsenic is known to cause liver and kidney injury in many humans and animals. The goal of this paper was to exemplify the...
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Frontier knowledge and future directions of programmed cell death in clear cell renal cell carcinoma
Clear cell renal cell carcinoma (ccRCC) is one of the most common renal malignancies of the urinary system. Patient outcomes are relatively poor due...
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Capturing time-dependent activation of genes and stress-response pathways using transcriptomics in iPSC-derived renal proximal tubule cells
Transcriptomic analysis is a powerful method in the utilization of New Approach Methods (NAMs) for identifying mechanisms of toxicity and application...
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Thallium Toxicity and its Interference with Potassium Pathways Tested on Various Cell Lines
Thallium (Tl) is a highly toxic heavy metal whose mechanism of toxicity is still not completely understood. The aim of this study was to test Tl...
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The role of RNA-modifying proteins in renal cell carcinoma
Gene expression is one of the most critical cellular processes. It is controlled by complex mechanisms at the genomic, epigenomic, transcriptomic,...
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Stress-responsive Gdf15 counteracts renointestinal toxicity via autophagic and microbiota reprogramming
The integrated stress response (ISR) plays a pivotal role in the cellular stress response, primarily through global translational arrest and the...
