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A selection pressure landscape for 870 human polygenic traits
Characterizing the natural selection of complex traits is important for understanding human evolution and both biological and pathological...
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Polygenic Vertisols and “Hidden” Vertisols of the Paraná River Basin, Argentina
Vertisols and soils with vertic properties occupy considerable areas in the east of the Pampa Region. Many of these Vertisols have particular...
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Insights into the architecture of human-induced polygenic selection in Duroc pigs
BackgroundAs one of the most utilized commercial composite boar lines, Duroc pigs have been introduced to China and undergone strongly human-induced...
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Testing the generalizability of ancestry-specific polygenic risk scores to predict prostate cancer in sub-Saharan Africa
BackgroundGenome-wide association studies do not always replicate well across populations, limiting the generalizability of polygenic risk scores...
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Integrative analysis of the plasma proteome and polygenic risk of cardiometabolic diseases
Cardiometabolic diseases are frequently polygenic in architecture, comprising a large number of risk alleles with small effects spread across the...
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Genome-wide association study identifies novel susceptible loci and evaluation of polygenic risk score for chronic obstructive pulmonary disease in a Taiwanese population
BackgroundChronic Obstructive Pulmonary Disease (COPD) describes a group of progressive lung diseases causing breathing difficulties. While COPD...
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No evidence that long runs of homozygosity tend to harbor risk variants for polygenic obesity in Labrador retriever dogs
Canine polygenic obesity can be influenced by relatively recent mutations with large effects. We determined whether, as with monogenic diseases, long...
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Non-linear machine learning models incorporating SNPs and PRS improve polygenic prediction in diverse human populations
Polygenic risk scores (PRS) are commonly used to quantify the inherited susceptibility for a trait, yet they fail to account for non-linear and...
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Whole‐exome sequencing analyses in a Saudi Ischemic Stroke Cohort reveal association signals, and shows polygenic risk scores are related to Modified Rankin Scale Risk
Ischemic stroke represents a significant societal burden across the globe. Rare high penetrant monogenic variants and less pathogenic common single...
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Polygenic risk prediction based on singular value decomposition with applications to alcohol use disorder
Background/aimThe polygenic risk score (PRS) shows promise as a potentially effective approach to summarize genetic risk for complex diseases such as...
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Distribution of 54 polygenic risk scores for common diseases in long lived individuals and their offspring
A surprising and well-replicated result in genetic studies of human longevity is that centenarians appear to carry disease-associated variants in...
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Dissecting polygenic signals from genome-wide association studies on human behaviour
Genome-wide association studies on human behavioural traits are producing large amounts of polygenic signals with significant predictive power and...
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Genetics of varicose veins reveals polygenic architecture and genetic overlap with arterial and venous disease
Varicose veins represent a common cause of cardiovascular morbidity, with limited available medical therapies. Although varicose veins are heritable...
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Polygenic scores for estimated glomerular filtration rate in a population of general adults and elderly – comparative results from the KORA and AugUR study
BackgroundPolygenic scores (PGSs) combining genetic variants found to be associated with creatinine-based estimated glomerular filtration rate (eGFR crea...
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Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients
Genome-wide association studies have demonstrated that polygenic risks shape Alzheimer’s disease (AD). To elucidate the polygenic architecture of AD...
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A polygenic risk score predicts mosaic loss of chromosome Y in circulating blood cells
BackgroundMosaic loss of Y chromosome (LOY) is the most common somatic change that occurs in circulating white blood cells of older men. LOY in...
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Associating complex traits with genetic variants: polygenic risk scores, pleiotropy and endophenotypes
Genotype–phenotype causal modeling has evolved significantly since Johannsen’s and Wright’s original designs were published. The development of...
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Genomic characterization of the world’s longest selection experiment in mouse reveals the complexity of polygenic traits
BackgroundLong-term selection experiments are a powerful tool to understand the genetic background of complex traits. The longest of such experiments...
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PUMAS: fine-tuning polygenic risk scores with GWAS summary statistics
Polygenic risk scores (PRSs) have wide applications in human genetics research, but often include tuning parameters which are difficult to optimize...
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Resource profile and user guide of the Polygenic Index Repository
Polygenic indexes (PGIs) are DNA-based predictors. Their value for research in many scientific disciplines is growing rapidly. As a resource for...
