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Insights from Proteomics in Kidney Disease Diagnosis and Various In Vitro and In Vivo Experimental Models
Kidney disease is emerging as a significant cause of mortality and public health burden worldwide. Diabetes, hypertension, obesity, and drug toxicity...
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Research progress on endoplasmic reticulum homeostasis in kidney diseases
The endoplasmic reticulum (ER) plays important roles in biosynthetic and metabolic processes, including protein and lipid synthesis, Ca 2+ homeostasis...
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LncRNA ANRIL mediates endothelial dysfunction through BDNF downregulation in chronic kidney disease
Endothelial dysfunction is common in patients with chronic kidney disease (CKD), but the mechanism is unknown. In this study, we found that the...
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Renal macrophages and NLRP3 inflammasomes in kidney diseases and therapeutics
Macrophages are exceptionally diversified cell types and perform unique features and functions when exposed to different stimuli within the specific...
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The microbial metabolite agmatine acts as an FXR agonist to promote polycystic ovary syndrome in female mice
Polycystic ovary syndrome (PCOS), an endocrine disorder afflicting 6–20% of women of reproductive age globally, has been linked to alterations in the...
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Association of Plasma Metal Levels with Outcomes of Assisted Reproduction in Polycystic Ovary Syndrome
The objective of this study is to explore the correlation of metal levels with assisted reproductive technology (ART) outcomes in polycystic ovary...
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Characterization of metal(loid)s and antibiotic resistance in bacteria of human gut microbiota from chronic kidney disease subjects
BackgroundHuman Gut Microbiota (HGM) is composed of more than one thousand species, playing an important role in the health status of individuals....
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Super-enhancer-driven metabolic reprogramming promotes cystogenesis in autosomal dominant polycystic kidney disease
Metabolic reprogramming is emerging as a key pathological contributor to the progression of autosomal dominant polycystic kidney disease (ADPKD), but...
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Transcriptome- and proteome-wide association studies nominate determinants of kidney function and damage
BackgroundThe pathophysiological causes of kidney disease are not fully understood. Here we show that the integration of genome-wide genetic,...
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Biochemical Clusters as Substitutes of Bone Biopsies in Kidney Transplant Patients
Bone and mineral metabolism abnormalities are frequent in kidney transplant recipients and have been associated with cardiovascular morbidity. The...
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Association of Serum Selenium and Selenoprotein P with Oxidative Stress Biomarkers in Patients with Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age which is characterized by various reproductive...
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Metabolic disorders induced by PNPLA3 and TM6SF2 gene variants affect chronic kidney disease in patients infected with non-genotype 3 hepatitis C virus
BackgroundPatients with chronic hepatitis C virus (HCV) infections differ in their risk for metabolic disorders and chronic kidney disease (CKD). The...
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Selenium Nanoparticles Modulate Steroidogenesis-Related Genes and Improve Ovarian Functions via Regulating Androgen Receptors Expression in Polycystic Ovary Syndrome Rat Model
Polycystic ovary syndrome (PCOS) occurs during the reproductive period in women and is characterized by reproductive, endocrine, and metabolic...
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Holistic expression of miR-17-92 cluster in obesity, kidney diseases, cardiovascular diseases, and diabetes
miR-17-92 cluster encodes six micro RNAs (miRNAs) and plays a crucial role in the regulation of various cellular processes. Aberrant expression of...
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Therapeutic Potential of Selenium Nanoparticles on Letrozole-Induced Polycystic Ovarian Syndrome in Female Wistar Rats
Polycystic ovarian syndrome (PCOS) is considered the most frequent gynecological endocrine disorder that causes anovulatory infertility. The current...
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Recent findings on the role of microRNAs in genetic kidney diseases
BackgroundMicroRNAs (miRNAs) are non-coding, endogenous, single-stranded, small (21–25 nucleotides) RNAs. Various target genes at the...
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Investigation of the Association of Serum Trace Elements Concentrations and Serum Biochemical Parameters with the Risk of Polycystic Ovary Syndrome: a Case–Control Study
Polycystic ovary syndrome (PCOS) is a heterogeneous endocrinological syndrome characterized by hyperandrogenism of ovarian origin and is often...
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Biomarkers of the End-Stage Renal Disease Progression: Beyond the GFR
AbstractChronic kidney disease can progress to the end-stage renal disease (ESRD) characterized by a high risk of morbidity and mortality. ESRD...
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Non-coding RNA genes modulate PI3K/AKT signaling pathway in polycystic ovary syndrome
BackgroundThe PI3K protein kinase B (PI3K/AKT) signaling pathway has crucial roles in insulin signaling and other endocrine disorders. The purpose of...
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Downregulation of praja2 restrains endocytosis and boosts tyrosine kinase receptors in kidney cancer
Clear cell renal cell carcinoma (ccRCC) is the most common kidney cancer in the adult population. Late diagnosis, resistance to therapeutics and...
