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Machine Learning and Computational Chemistry for the Endocannabinoid System
Computational methods in medicinal chemistry facilitate drug discovery and design. In particular, machine learning methodologies have recently gained...
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Endocannabinoid-Binding Receptors as Drug Targets
Cannabis plant has been used from ancient times with therapeutic purposes for treating human pathologies, but the identification of the cellular and...
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Protective Effects of Resveratrol on Brain Edema and Microstructural Changes in Human Brain After Acute Alcohol Intake: Assessment by Diffusion Weighted Kurtosis Imaging
Resveratrol can initiate anti-alcoholic functions in the human body. Magnetic resonance diffusion kurtosis imaging (DKI) can comprehensively evaluate...
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Molekulare Sensoren von Makro- und Mikronährstoffen
In diesem Kapitel werden zunächst grundlegende Stoffwechselprinzipien beschrieben. Danach werden die molekularen Mechanismen erläutert, über die...
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Effect of Leucine-enkephalin on Lipid Deposition and GSK-3β/mTOR Signaling in the Liver of Zebrafish
In the current study, we evaluated the effect of leucine-enkephalin (L-ENK) on lipid deposition and GSK-3β/mTOR signaling in zebrafish. Zebrafish...
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Manipulation of photoperiod induces fat storage, but not fat mobilization in the migratory songbird, Dumetella carolinensis (Gray Catbird)
The annual cycle of migratory birds requires significant phenotypic remodeling. We sought to induce the migratory phenotype in Gray Catbirds by...
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Protein–Protein Interactions in Immune Disorders and Inflammation
Immune system disorders arise when the immune system is either over-activated or depressed. Autoimmune disorders that affect millions of people...
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Beyond energy provider: multifunction of lipid droplets in embryonic development
Since the discovery, lipid droplets (LDs) have been recognized to be sites of cellular energy reserves, providing energy when necessary to sustain...
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The effect of saraglitazar on TGF-β-induced smad3 phosphorylation and expression of genes related to liver fibrosis in LX2 cell line
Background and purposeLiver fibrosis is a reversible liver injury that occurs as a result of many chronic inflammatory diseases and can lead to...
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Dietary conjugated linoleic acid and medium-chain triglycerides for obesity management
Obesity is considered a serious global health issue. Patients have been predisposed to comorbidities such as dyslipidemia, cardiovascular diseases,...
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Harnessing peroxisome proliferator-activated receptor γ agonists to induce Heme Oxygenase-1: a promising approach for pulmonary inflammatory disorders
The activation of peroxisome proliferator-activated receptor (PPAR)-γ has been extensively shown to attenuate inflammatory responses in conditions...
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Identification of circRNAs expression profiles and functional networks in parotid gland of type 2 diabetes mouse
BackgroundCircular RNAs (circRNAs) are a novel kind of non-coding RNAs proved to play crucial roles in the development of multiple diabetic...
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Advances in polysaccharides of natural source of anti-diabetes effect and mechanism
PurposeDiabetes is a chronic disease in metabolic disorder, and the pathology is characterized by insulin resistance and insulin secretion disorder...
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An insight to treat cardiovascular diseases through phytochemicals targeting PPAR-α
Peroxisome proliferator-activated receptor-α (PPAR-α) belonging to the nuclear hormone receptor superfamily is a promising target for CVDs which...
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Anti-obesity potentiality of Lactiplantibacillus plantarum E2_MCCKT isolated from a fermented beverage, haria: a high fat diet-induced obese mice model study
Obesity is a growing epidemic worldwide. Several pharmacologic drugs are being used to treat obesity but these medicines exhibit side effects. To...
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pparβ regulates lipid catabolism by mediating acox and cpt-1 genes in Scophthalmus maximus under heat stress
Peroxisome proliferator–activated receptor β ( pparβ ) is a key gene–regulating lipid metabolism pathway, but its function in turbot remains unclear....
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ACSS2 controls PPARγ activity homeostasis to potentiate adipose-tissue plasticity
The appropriate transcriptional activity of PPARγ is indispensable for controlling inflammation, tumor and obesity. Therefore, the identification of...
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The benefits of flushing with Lemuru fish oil as a source of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on the performance of reproductive parameters in Garut ewes
This study aimed to evaluate and analyze the effects of a flushing diet containing Docosahexaenoic acid (DHA) and Eicosapentaenoic acid (EPA) from...
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Vitamin A regulates mitochondrial biogenesis and function through p38 MAPK-PGC-1α signaling pathway and alters the muscle fiber composition of sheep
BackgroundVitamin A (VA) and its metabolite, retinoic acid (RA), are of great interest for their wide range of physiological functions. However, the...
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Exploring the nexus of nuclear receptors in hematological malignancies
Hematological malignancies (HM) represent a subset of neoplasms affecting the blood, bone marrow, and lymphatic systems, categorized primarily into...
