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Proteomic features of skeletal muscle adaptation to resistance exercise training as a function of age
Resistance exercise training (RET) can counteract negative features of muscle ageing but older age associates with reduced adaptive capacity to RET....
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Immunomodulatory amnion-derived mesenchymal stromal cells preserve muscle function in a mouse model of Duchenne muscular dystrophy
BackgroundDuchenne muscular dystrophy (DMD) is an incurable genetic disease characterized by degeneration and necrosis of myofibers, chronic...
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Skeletal Muscle Energy Metabolism & Contraction
Skeletal muscle contraction and energy metabolism are closely intertwined processes essential for maintaining physiological functions and supporting...
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Electrophysiology of Ctenophore Smooth Muscle
Unlike in the Cnidaria, where muscle cells are coupled together into an epithelium, ctenophore muscles are single, elongated, intramesogleal...
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Influence of 2,3-Butanedione Monoxime on the Actin–Myosin Interaction in Modeling Healthy Function and Congenital Myopathy in a Single Muscle Fiber
AbstractCongenital myopathies are a heterogeneous group of human skeletal muscle disorders characterized by muscle hypotonia and weakness. The...
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Muscle Stem Cell Function Is Impaired in β2-Adrenoceptor Knockout Mice
Knockout (ko) mice for the β2 adrenoceptor (Adrβ2) have impaired skeletal muscle regeneration, suggesting that this receptor is important for muscle...
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Serine Administration Improves Selenium Status, Oxidative Stress, and Mitochondrial Function in Longissimus Dorsi Muscle of Piglets with Intrauterine Growth Retardation
Intrauterine growth retardation (IUGR) causes oxidative stress in the skeletal muscle. Serine and selenoproteins are involved in anti-oxidative...
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Human skeletal muscle aging atlas
Skeletal muscle aging is a key contributor to age-related frailty and sarcopenia with substantial implications for global health. Here we profiled...
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IL4I1-catalyzed tryptophan metabolites mediate the anti-inflammatory function of cytokine-primed human muscle stem cells
Muscle stem cells (MuSCs) have been demonstrated to exert impressive therapeutic efficacy in disease settings through orchestrating inflammatory...
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Associations between PBMC whole genome transcriptome, muscle strength, muscle mass, and physical performance in healthy home-dwelling older women
Increasing age is accompanied by many changes, including declining functional skeletal muscle health and immune dysfunction. Peripheral blood...
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Skeletal Muscle Regeneration in Zebrafish
Muscle regeneration models have revealed mechanisms of inflammation, wound clearance, and stem cell–directed repair of damage, thereby informing...
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Angular and Linear Accelerations, Ear, and the Skeletal Muscle
The ear serves two vital functions of hearing and maintaining balance. It achieves these roles within three major compartments: the outer, the...
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In Vivo Investigation of Gene Function in Muscle Stem Cells by CRISPR/Cas9-Mediated Genome Editing
Skeletal muscle satellite cells (SCs) are adult stem cells responsible for muscle development and injury-induced muscle regeneration. Functional...
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Skeletal Muscle Formation, Regeneration, and Recovery from Injury
In this chapter, we embark on a journey through the remarkable world of skeletal muscle formation, regeneration, and recovery from injury. Skeletal...
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Relationship Between Plasma Homocysteine and Bone Density, Lean Mass, Muscle Strength and Physical Function in 1480 Middle-Aged and Older Adults: Data from NHANES
Hyperhomocysteinemia induces oxidative stress and chronic inflammation (both of which are catabolic to bone and muscle); thus, we examined the...
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Muscle spindle function in healthy and diseased muscle
Almost every muscle contains muscle spindles. These delicate sensory receptors inform the central nervous system (CNS) about changes in the length of...
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MuSCs and IPCs: roles in skeletal muscle homeostasis, aging and injury
Skeletal muscle is a highly specialized tissue composed of myofibres that performs crucial functions in movement and metabolism. In response to...
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The transcription regulator ATF4 is a mediator of skeletal muscle aging
Aging slowly erodes skeletal muscle strength and mass, eventually leading to profound functional deficits and muscle atrophy. The molecular...
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Nuclear smooth muscle α-actin participates in vascular smooth muscle cell differentiation
Missense variants throughout ACTA2 , encoding α-smooth muscle actin (αSMA), predispose to adult-onset thoracic aortic disease, but variants disrupting...
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Lipid Transfer Protein Genes Are Differently Expressed in Rat Soleus Muscle at Early and Later Periods of Muscle Disuse
AbstractThis work reports analysis of lipid transfer protein (LTPs) mRNA levels in rat soleus muscle after 12-h and 14-day hindlimb suspension (HS)....
