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Global gene expression profiling of perirenal brown adipose tissue whitening in goat kids reveals novel genes linked to adipose remodeling
BackgroundBrown adipose tissue (BAT) is known to be capable of non-shivering thermogenesis under cold stimulation, which is related to the mortality...
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Fat accumulation in striped hamsters (Cricetulus barabensis) reflects the temperature of prior cold acclimation
BackgroundProper adjustments of metabolic thermogenesis play an important role in thermoregulation in endotherm to cope with cold and/or warm ambient...
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Adtrp regulates thermogenic activity of adipose tissue via mediating the secretion of S100b
Brown and beige adipose tissues dissipate chemical energy in the form of heat to maintain your body temperature in cold conditions. The impaired...
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Mitochondrial RNA stimulates beige adipocyte development in young mice
Childhood obesity is a serious public health crisis and a critical factor that determines future obesity prevalence. Signals affecting adipocyte...
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RNA-Seq reveals miRNA role in thermogenic regulation in brown adipose tissues of goats
BackgroundMicroRNAs (miRNAs) are a family of short non-coding RNA molecules and play important roles in various biological processes. However,...
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Effect of acute cold exposure on cardiac mitochondrial function: role of sirtuins
Cardiac function depends mainly on mitochondrial metabolism. Cold conditions increase the risk of cardiovascular diseases by increasing blood...
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The anorectic and thermogenic effects of pharmacological lactate in male mice are confounded by treatment osmolarity and co-administered counterions
Lactate is a circulating metabolite and a signalling molecule with pleiotropic physiological effects. Studies suggest that lactate modulates energy...
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Pre-hibernation diet alters skeletal muscle relaxation kinetics, but not force development in torpid arctic ground squirrels
During the hibernation season, Arctic ground squirrels (AGS) experience extreme temperature fluctuations (body temperature, T b , as low as − 3 °C),...
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Age-Related Expression Dynamics of Uncoupling Protein 1 in Adipose Tissues of ICR Outbred Mice during Postnatal Ontogenesis
AbstractMitochondrial uncoupling protein (UCP1) facilitates adaptive non-shivering thermogenesis in brown and beige adipocytes due to uncoupling of...
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Catalase deficiency facilitates the shuttling of free fatty acid to brown adipose tissue through lipolysis mediated by ROS during sustained fasting
BackgroundFatty acids (FA) derived from adipose tissue and liver serve as the main fuel in thermogenesis of brown adipose tissue (BAT). Catalase, a...
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Energy and Water Balance of Marsupials
The endothermic physiology of marsupials is broadly consistent with that of placental mammals; patterns and mechanisms of temperature regulation are...
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COVID-19 instigates adipose browning and atrophy through VEGF in small mammals
Patients with COVID-19 frequently manifest adipose atrophy, weight loss and cachexia, which significantly contribute to poor quality of life and...
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Walnut supplementation increases levels of UCP1 and CD36 in brown adipose tissue independently of diet type
Dietary interventions that modulate the brown adipose tissue (BAT) thermogenic activity could represent a promising therapy for metabolic disorders....
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Energy and Water Balance of Marsupials
The endothermic physiology of marsupials is broadly consistent with that of placental mammals; patterns and mechanisms of temperature regulation are...
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The fibroblast growth factor receptor antagonist SSR128129E inhibits fat accumulation via suppressing adipogenesis in mice
BackgroundAS an allosteric inhibitor of fibroblast growth factor receptors (FGFRs), SSR128129E (SSR) extensively inhibits the fibroblast growth...
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Cold exposure alters lipid metabolism of skeletal muscle through HIF-1α-induced mitophagy
BackgroundIn addition to its contractile properties and role in movement, skeletal muscle plays an important function in regulating whole-body...
