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Monitoring and modelling the glutamine metabolic pathway: a review and future perspectives
BackgroundAnalysis of the glutamine metabolic pathway has taken a special place in metabolomics research in recent years, given its important role in...
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Metabolic reprogramming in the OPA1-deficient cells
OPA1, a dynamin-related GTPase mutated in autosomal dominant optic atrophy, is essential for the fusion of the inner mitochondrial membrane. Although...
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Putting the energetic-savings hypothesis underground: fossoriality does not affect metabolic rates in amphibians
By living underground, fossorial animals may be challenged by limited gas exchange due to prolonged exposure to low oxygen levels (hypoxia) and...
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The Synergistic Trio of Metabolic Master Regulators Sustaining a Vicious Circle of Pathological Processes in Post-Traumatic Stress Disorder
AbstractPost-traumatic stress disorder (PTSD) is a maladaptive response to the exposure of an extraordinary-intensity stressor. The animal and human...
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Untargeted metabolomic, and proteomic analysis identifies metabolic biomarkers and pathway alterations in individuals with 22q11.2 deletion syndrome
IntroductionThe chromosome 22q11.2 deletion syndrome (22q11.2DS) is characterized by a well-defined microdeletion and is associated with a wide range...
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The Relationship of Fatigue and Depression with Trace Element Levels in Epileptic Patients
In this study, it was investigated whether there are trace element abnormalities in epileptic patients, the relationship of trace elements with...
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Role of Brain–Gut–Microbiome Axis in Depression Comorbid with Asthma
Asthma (ATA) is a long term inflammatory condition of the respiratory tract (RT) where stress and psychological factors play a significant role. A...
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Local-scale thermal history influences metabolic response of marine invertebrates to warming
As climate change continues, anticipating species’ responses to rising temperatures requires an understanding of the drivers of thermal sensitivity,...
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A metabolic biomarker panel of restless legs syndrome in peritoneal dialysis patients
BackgroundRestless legs syndrome (RLS) is a neuromotor disorder, and dialysis patients are more likely to develop RLS. RLS often causes sleep...
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Systemic GDF11 attenuates depression-like phenotype in aged mice via stimulation of neuronal autophagy
Cognitive decline and mood disorders increase in frequency with age. Many efforts are focused on the identification of molecules and pathways to...
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Diet switch pre-vaccination improves immune response and metabolic status in formerly obese mice
Metabolic disease is epidemiologically linked to severe complications upon influenza virus infection, thus vaccination is a priority in this...
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Ultrasonic vocalisation rate tracks the diurnal pattern of activity in winter phenotype Djungarian hamsters (Phodopus sungorus)
Vocalisations are increasingly being recognised as an important aspect of normal rodent behaviour yet little is known of how they interact with other...
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Multi-cohort analysis of depression-associated gut bacteria sheds insight on bacterial biomarkers across populations
Gut microbes are associated with the development of depression based on extensive evidence. However, previous studies have led to conflicting reports...
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Urine Metabolomics Reveals Overlap** Metabolic Associations Between Preeclampsia and Gestational Diabetes
Pregnancy is associated with numerous metabolic adaptations to meet the demands of the growing foetus. These adaptations could be perturbed during...
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Spatially resolved metabolomics and isotope tracing reveal dynamic metabolic responses of dentate granule neurons with acute stimulation
Neuronal activity creates an intense energy demand that must be met by rapid metabolic responses. To investigate metabolic adaptations in the...
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Investigating metabolic dysregulation in serum of triple transgenic Alzheimer’s disease male mice: implications for pathogenesis and potential biomarkers
Alzheimer’s disease (AD) is a multifactorial neurodegenerative disease that lacks convenient and accessible peripheral blood diagnostic markers and...
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Effect of Intranasal Insulin on Metabolic Parameters and Inflammation Factors in Diabetic Rats Exposed to Cerebral Ischemia-Reperfusion
AbstractThe search for natural biologically active substances having a neuroprotective effect against cerebral ischemia-reperfusion injury is one of...
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Salivary bacterial signatures in depression-obesity comorbidity are associated with neurotransmitters and neuroactive dipeptides
BackgroundDepression and obesity are highly prevalent, often co-occurring conditions marked by inflammation. Microbiome perturbations are implicated...
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Interactions between central nervous system and peripheral metabolic organs
According to Descartes, minds and bodies are distinct kinds of “substance”, and they cannot have causal interactions. However, in neuroscience, the...
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Mitochondrial fission drives neuronal metabolic burden to promote stress susceptibility in male mice
Neurons are particularly susceptible to energy fluctuations in response to stress. Mitochondrial fission is highly regulated to generate ATP via...
