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Molecular identification of phytoplasma associated with brinjal little leaf disease in Sri Lanka
Brinjal ( Solanum melongena ) cultivation has been severely affected by Brinjal Little Leaf (BLL) disease in countries including Sri Lanka. The biotic...
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Modeling the Hydraulic Transport of Wastewater and Anaerobic Uptake of Organics by PAOs and GAOs During the Feeding of a Granular Sludge Reactor
The designDesign of biomassBiomass bedsBed and feeding conditionsFeeding conditions is crucial for an optimal loading, microbial selectionMicrobial... -
IP3R1-mediated MAMs formation contributes to mechanical trauma-induced hepatic injury and the protective effect of melatonin
IntroductionThere is a high morbidity and mortality rate in mechanical trauma (MT)-induced hepatic injury. Currently, the molecular mechanisms...
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Application of CRISPR-Based Technology in Medical Research and Disease Treatment
Seeking treatments for human diseases is an important goal and motivation of biomedical research. Over thousands of years, humans have gradually... -
The impact of the gut microbiota on T cell ontogeny in the thymus
The intestinal microbiota is critical for the development of gut-associated lymphoid tissues, including Peyer’s patches and mesenteric lymph nodes,...
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PTEN directs developmental and metabolic signaling for innate-like T cell fate and tissue homeostasis
Phosphatase and tensin homologue (PTEN) is frequently mutated in human cancer, but its roles in lymphopoiesis and tissue homeostasis remain poorly...
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Intravenous Bacille Calmette–Guérin vaccination protects simian immunodeficiency virus-infected macaques from tuberculosis
Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), is the most common cause of death in people living with human immunodeficiency virus (HIV)....
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Creation of Yeast Models for Evaluating the Pathogenicity of Mutations in the Human Mitochondrial Gene MT-ATP6 and Discovering Therapeutic Molecules
Numerous diseases in humans have been associated with mutations of the mitochondrial genome (mtDNA). This genome encodes 13 protein subunits of... -
Optimal number of replications and test locations for soybean yield trials in Brazil
An optimal number of test locations and replications in yield trials allows improvements in the efficiency of a breeding program and selection...
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Analysis of Expression, Mutation, and Alternative Splice Variants of Candidate Genes, MLO2 and MLO6A, Involved in Powdery Mildew Susceptibility in Mulberry (Morus spp.)
Mulberry is a fast-growing perennial crop commercially exploited as the sole source of food for the mulberry silkworm, Bombyx mori , for the...
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Tigers on the edge: mortality and landscape change dominate individual-based spatially-explicit simulations of a small tiger population
ContextReductions in the tiger’s ( Panthera tigris ) range in Southeast Asia have been concurrent with large infrastructure expansion and landscape...
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TRAV1-2+ CD8+ T-cells including oligoconal expansions of MAIT cells are enriched in the airways in human tuberculosis
Mucosal-associated invariant T (MAIT) cells typically express a TRAV1-2 + semi-invariant TCRα that enables recognition of bacterial, mycobacterial,...
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Effect of Unmetabolized Folic Acid on Immunoinflammatory Markers in Sickle Cell Disease Patients Taking Folic Acid Supplementation
Folic acid (FA) supplementation in sickle cell disease (SCD) patients lead to accumulation of unmetabolized folic acid (UMFA) which might influence...
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Can AlphaFold’s breakthrough in protein structure help decode the fundamental principles of adaptive cellular immunity?
T cells are essential immune cells responsible for identifying and eliminating pathogens. Through interactions between their T-cell antigen receptors...
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The Evolution of Redfishes of the Genus Sebastes (Perciformes: Sebastidae) of the Atlantic and Arctic Oceans: Budding Speciation in a Species Flock
AbstractThe evolutionary history of North Atlantic Sebastes redfishes was reconstructed as a result of studying the mitochondrial DNA D-loop...
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Mucosal-Associated Invariant T Cells in Tumors of Epithelial Origin
Mucosal-associated invariant T (MAIT) cells are innate T lymphocytes that circulate in blood and also reside in mucosal tissues. Blood MAIT cells are... -
CAR Cells beyond Classical CAR T Cells: Functional Properties and Prospects of Application
AbstractChimeric antigen receptors (CARs) are genetically engineered receptors that recognize antigens and activate signaling cascades in a cell....
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Comparison of Enzymatic Activity of Novel Recombinant L-asparaginases of Extremophiles
AbstractThe activity of novel uncharacterized extremophilic L-asparaginases from the psychrophilic fungi Sclerotinia borealis , the thermoacidophilic...
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Analysing the role of anthropogenic intervention in reconfiguring the hydromorphology of the sub-Himalayan river systems in India: a comparative assessment between the Mahananda–Balason and Chel–Neora systems
This study compares the hydromorphological quality of two sub-Himalayan Rivers, the Mahananda–Balason system (MBS) and the Chel–Neora system (CNS),...