Search
Search Results
-
Large-Scale Manipulative Experiments
This chapter provides an overview of manipulative experiments conducted at spatial extents of 15 ha or larger in forest, grassland, and aquatic...
-
PMFFRC: a large-scale genomic short reads compression optimizer via memory modeling and redundant clustering
BackgroundGenomic sequencing reads compressors are essential for balancing high-throughput sequencing short reads generation speed, large-scale...
-
Synthetic lethality in large-scale integrated metabolic and regulatory network models of human cells
Synthetic lethality (SL) is a promising concept in cancer research. A wide array of computational tools has been developed to predict and exploit...
-
Identification of genetic variants that impact gene co-expression relationships using large-scale single-cell data
BackgroundExpression quantitative trait loci (eQTL) studies show how genetic variants affect downstream gene expression. Single-cell data allows...
-
Epigenetic landscape of drug responses revealed through large-scale ChIP-seq data analyses
BackgroundElucidating the modes of action (MoAs) of drugs and drug candidate compounds is critical for guiding translation from drug discovery to...
-
Age-related differences in network controllability are mitigated by redundancy in large-scale brain networks
The aging brain undergoes major changes in its topology. The mechanisms by which the brain mitigates age-associated changes in topology to maintain...
-
Large-scale F0 CRISPR screens in vivo using MIC-Drop
The zebrafish is a powerful model system for studying animal development, for modeling genetic diseases, and for large-scale in vivo functional...
-
Understanding genetic variability: exploring large-scale copy number variants through non-invasive prenatal testing in European populations
Large-scale copy number variants (CNVs) are structural alterations in the genome that involve the duplication or deletion of DNA segments,...
-
Large-scale whole-exome sequencing of neuropsychiatric diseases and traits in 350,770 adults
While numerous genomic loci have been identified for neuropsychiatric conditions, the contribution of protein-coding variants has yet to be...
-
Characterization of large-scale genomic differences in the first complete human genome
BackgroundThe first telomere-to-telomere (T2T) human genome assembly (T2T-CHM13) release is a milestone in human genomics. The T2T-CHM13 genome...
-
GBC: a parallel toolkit based on highly addressable byte-encoding blocks for extremely large-scale genotypes of species
Whole -genome sequencing projects of millions of subjects contain enormous genotypes, entailing a huge memory burden and time for computation. Here,...
-
Large-scale integration of single-cell transcriptomic data captures transitional progenitor states in mouse skeletal muscle regeneration
Skeletal muscle repair is driven by the coordinated self-renewal and fusion of myogenic stem and progenitor cells. Single-cell gene expression...
-
Large-scale computational modelling of the M1 and M2 synovial macrophages in rheumatoid arthritis
Macrophages play an essential role in rheumatoid arthritis. Depending on their phenotype (M1 or M2), they can play a role in the initiation or...
-
Development of a repetitive DNA marker for identification of the exotic large-scale loach introduced to Japan
The large-scale loach Paramisgurnus dabryanus is a freshwater fish native to East Asia except for Japan. However, its presence has been observed in...
-
Using mobile device built-in microphones to monitor bats: a new opportunity for large-scale participatory science initiatives
Citizen science has become a crucial tool in biodiversity monitoring, often facilitated by the diffusion of mobile devices, such as smartphones and...
-
Large-scale lexical and genetic alignment supports a hybrid model of Han Chinese demic and cultural diffusions
The Han Chinese history is shaped by substantial demographic activities and sociocultural transmissions. However, it remains challenging to assess...
-
Large-scale genome sequencing redefines the genetic footprints of high-altitude adaptation in Tibetans
BackgroundTibetans are genetically adapted to high-altitude environments. Though many studies have been conducted, the genetic basis of the...
-
CHESS 3: an improved, comprehensive catalog of human genes and transcripts based on large-scale expression data, phylogenetic analysis, and protein structure
CHESS 3 represents an improved human gene catalog based on nearly 10,000 RNA-seq experiments across 54 body sites. It significantly improves current...
-
Correcting batch effects in large-scale multiomics studies using a reference-material-based ratio method
BackgroundBatch effects are notoriously common technical variations in multiomics data and may result in misleading outcomes if uncorrected or...
-
Large-scale growth of C. elegans and isolation of membrane protein complexes
Purification of membrane proteins for biochemical and structural studies is commonly achieved by recombinant overexpression in heterologous cell...
