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Functions of the RIP kinase family members in the skin
The receptor interacting protein kinases (RIPK) are a family of serine/threonine kinases that are involved in the integration of various stress...
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Adenylate kinase phosphate energy shuttle underlies energetic communication in flagellar axonemes
The complexities of energy transfer mechanisms in the flagella of mammalian sperm flagella have been intensively investigated and demonstrate...
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Pharmacology of LRRK2 with type I and II kinase inhibitors revealed by cryo-EM
LRRK2 is one of the most promising drug targets for Parkinson’s disease. Though type I kinase inhibitors of LRRK2 are under clinical trials,...
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LRRK2 phosphorylation status and kinase activity regulate (macro)autophagy in a Rab8a/Rab10-dependent manner
Mutations in the leucine-rich repeat kinase 2 ( LRRK2 ) gene are the most common genetic cause of Parkinson’s disease (PD), with growing importance...
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Cell-permeable PI3 kinase competitive peptide inhibits KIT mutant mediated tumorigenesis of gastrointestinal stromal tumor (GIST)
BackgroundMutations in the receptor tyrosine kinase KIT are the main cause of gastrointestinal stromal tumor (GIST), and the KIT mutants mediated PI3...
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Conformational Transitions in EGFR Protein Tyrosine Kinase Domain and Their Modulation by Mutants
The epidermal growth factor receptor (EGFR) is a membrane protein with intracellular kinase activity. The EGFR plays a significant role in the cell...
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Regulation of Plant Infection Processes by MAP Kinase Pathways in Ascomycetous Pathogens
Plant pathogenic fungi use the well-conserved MAP kinase (MAPK) pathways to mediate responses to external stimuli and regulate various infection and...
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The LRR receptor-like kinase ALR1 is a plant aluminum ion sensor
Plant survival requires an ability to adapt to differing concentrations of nutrient and toxic soil ions, yet ion sensors and associated signaling...
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Fortify the defense frontline: MAPKs phosphorylate receptor-like cytoplasmic kinase to maintain plant resistance in soybean
Mitogen-activated protein kinase (MAPK) activation is one of the significant immune events that respond to pathogens in plants. A MAPK cascade often...
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Potential protein kinase inhibitors that target G-quadruplex DNA structures in the human telomeric regions
Telomeric regions contain Guanine-rich sequences arranged in a planar manner and connected by Hoogsteen hydrogen bonds that can fold into...
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A resource database for protein kinase substrate sequence-preference motifs based on large-scale mass spectrometry data
BackgroundProtein phosphorylation is one of the most prevalent posttranslational modifications involved in molecular control of cellular processes,...
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Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function
Activation of receptor protein kinases is prevalent in various cancers with unknown impact on ferroptosis. Here we demonstrated that AKT activated by...
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In silico screening of Fyn kinase inhibitors using classification-based QSAR model, molecular docking, molecular dynamics and ADME study
This study aimed to use a computational approach that combined the classification-based QSAR model, molecular docking, ADME studies, and molecular...
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Wall-Associated Kinase (WAK) and WAK-like Kinase Gene Family in Sugar Beet: Genome-Wide Characterization and In Silico Expression Analysis in Response to Beet Cyst Nematode (Heterodera schachtii Schmidt) Infection
The wall-associated kinase ( WAK ) and WAK-associated kinase-like ( WAKL ) genes belong to the major receptor-like kinase ( RLK ) gene family in plants....
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Paxillin participates in the sphingosylphosphorylcholine-induced abnormal contraction of vascular smooth muscle by regulating Rho-kinase activation
BackgroundThe Ca 2+ -independent contraction of vascular smooth muscle is a leading cause of cardiovascular and cerebrovascular spasms. In the...
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The kinase activity of integrin-linked kinase regulates cellular senescence in gastric cancer
The activity of integrin-linked kinase (ILK) in cancerous cells is often oncogenic and associated with malignant properties, such as uncontrolled...
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Assessment of structural and activity-related contributions of various PIM-1 kinase inhibitors in the treatment of leukemia and prostate cancer
One of the most perilous illnesses in the world is cancer. The cancer may be associated with the mutation of different genes inside the body. The PIM...
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ZBP1 causes inflammation by inducing RIPK3-mediated necroptosis and RIPK1 kinase activity-independent apoptosis
Z-DNA binding protein 1 (ZBP1) has important functions in anti-viral immunity and in the regulation of inflammatory responses. ZBP1 induces...
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Hub stability in the calcium calmodulin-dependent protein kinase II
The calcium calmodulin protein kinase II (CaMKII) is a multi-subunit ring assembly with a central hub formed by the association domains. There is...
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Multimodal multi-task deep neural network framework for kinase–target prediction
Kinase plays a significant role in various disease signaling pathways. Due to the highly conserved sequence of kinase family members, understanding...
