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The first evidence of biological activity for free Hypusine, an enigmatic amino acid discovered in the '70s
Hypusine amino acid [ N ε -(4-amino-2-hydroxybutyl)-lysine] was first isolated in 1971 from bovine brain extracts. Hypusine originates from a...
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Recent Insights into the Structure and Function of Mycobacterial Membrane Proteins Facilitated by Cryo-EM
AbstractMycobacterium tuberculosis (Mtb) is one of the deadliest pathogens encountered by humanity. Over the decades, its characteristic membrane...
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Investigation of cholinesterase and α-glucosidase enzyme activities, and molecular docking and dft studies for 1,2-disubstituted cyclopentane derivatives with phenyl and benzyl units
Six known products ( 4 – 9 ) were prepared from reaction of adipoyl chloride with 1,2,3-trimethoxybenzene according to the literature. From...
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Design, synthesis and herbicidal activity of novel cyclohexanedione derivations containing pyrazole and pyridine groups as potential HPPD inhibitors
4-Hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27; HPPD) is one of the important target enzymes in the development of herbicides. To discover novel...
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Phomopsis liquidambaris reduces ethylene biosynthesis in rice under salt stress via inhibiting the activity of 1-aminocyclopropane-1-carboxylate deaminase
The endophytic fungus Phomopsis liquidambaris is characterized as a plant growth-promoting agent under salt stress, but its mechanism is unknown....
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Denitrifying Woodchip Bioreactors: A Microbial Solution for Nitrate in Agricultural Wastewater—A Review
Nitrate (NO 3 − ) is highly water-soluble and considered to be the main nitrogen pollutants leached from agricultural soils. Its presence in aquatic...
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Organelle-specific Mechanisms of Ferroptosis
Ferroptosis, which occurs due to the peroxidation of unsaturated lipids, is associated with several pathological conditions. The fate of a...
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Current state, strategies, and perspectives in enhancing artemisinin production
The compound artemisinin is attributed to several biological activities including antimalaria for which it is popularly known. However, its...
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Design, Synthesis, In Silico Molecular Docking, ADMET Studies, and Biological Evaluation of Novel Substituted Diphenyl Pyrazole Incorporated 1,2,3-Triazolyl Benzene Sulfonamides
AbstractObjective: A novel triazolyl benzene sulfonamides were synthesized and evaluated for antitubercular and anticancer activity. Methods: Our...
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Transcriptome sequencing and metabolome analysis reveal the molecular mechanism of Salvia miltiorrhiza in response to drought stress
Salvia miltiorrhiza is commonly used as a Chinese herbal medicine to treat different cardiovascular and cerebrovascular illnesses due to its active...
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Sex-specific preservation of neuromuscular function and metabolism following systemic transplantation of multipotent adult stem cells in a murine model of progeria
Onset and rates of sarcopenia, a disease characterized by a loss of muscle mass and function with age, vary greatly between sexes. Currently, no...
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Diaryl Pyrazoline, 1,3,4-Oxadizole, and 1,2,4-Triazole Pharmacophore Hybridization: Design, Synthesis, HDAC Inhibition, and Caspase 3/7 Activation Studies
AbstractObjective: The study aimed to employ the pharmacophore hybridization technique for the synthesis of novel anticancer compounds by combining...
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The nephrotoxin ochratoxin a impairs resilience of energy homeostasis of human proximal tubule cells
Despite a long history of research, the mode of action of the mycotoxin ochratoxin A (OTA) is still not clear. Based on our observation that...
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Functional gene composition and metabolic potential of deep-sea coral-associated microbial communities
Over the past decade, an abundance of 16S rRNA gene surveys have provided microbiologists with data regarding the prokaryotes present in a...
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Monitoring Mitochondrial Function in Mouse Embryonic Stem Cells (mESCs)
Mouse embryonic stem cells (mESCs) can be grown in culture, recapitulating the different states of pluripotency of their in vivo counterparts, with...
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An efficient eco-friendly, simple, and green synthesis of some new spiro-N-(4-sulfamoyl-phenyl)-1,3,4-thiadiazole-2-carboxamide derivatives as potential inhibitors of SARS-CoV-2 proteases: drug-likeness, pharmacophore, molecular docking, and DFT exploration
IntroductionThe coronavirus disease 2019 (COVID-19) pandemic has caused a global health crisis. The severe acute respiratory syndrome coronavirus 2...
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An Update on Isolation of Functional Mitochondria from Cells for Bioenergetics Studies
Mitochondria are the organelles where the most fundamental processes of energy transformation within the cell are located. They are also involved in...
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Recent Advances in Poly-(γ-Glutamic Acid) Production by Microbial Fermentation
Poly (γ-glutamic acid) (γ-PGA) is a microbial biopolymer composed of D- and L-glutamic acid monomers connected by γ-amide linkage. γ-PGA is...
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Study on the Antioxidant Effects of Suaeda rigida Polysaccharides In Vitro and In Vivo
AbstractThe objectives of this study were to investigate the antioxidant effects of Suaeda rigida polysaccharide (SRPs) in vitro and in vivo. Three...
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Effect of graphene / metal nanocomposites on the key genes involved in rosmarinic acid biosynthesis pathway and its accumulation in Melissa officinalis
BackgroundRecently, numerous investigations have been done to study graphene and silver nanoparticle in the fields of agriculture and medicine . In...
