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Role of YAP in hematopoietic differentiation and erythroid lineage specification of human-induced pluripotent stem cells
BackgroundIn vitro production of hematopoietic stem/progenitor cells (HSPCs) from human-induced pluripotent stem cells (hiPSCs) provides...
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Long-term expansion of human hematopoietic stem cells
Hematopoietic stem cells (HSCs) are critical for the treatment of a variety of hematological diseases. However, the low number of HSCs lead to the...
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Chromosomal Analysis in Lineage-Specific Mouse Hematopoietic Stem Cells and Progenitors
Hematopoiesis is maintained throughout life from the hematopoietic stem cell niche in which hematopoietic stem cells and lineage-specific...
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Saracatinib prompts hemin-induced K562 erythroid differentiation but suppresses erythropoiesis of hematopoietic stem cells
Human myeloid leukemia cells (such as K562) could be used for the study of erythropoiesis, and mature erythroid markers and globins could be induced...
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TET2 modulates spatial relocalization of heterochromatin in aged hematopoietic stem and progenitor cells
DNA methylation deregulation at partially methylated domains (PMDs) represents an epigenetic signature of aging and cancer, yet the underlying...
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Base Editors-Mediated Gene Therapy in Hematopoietic Stem Cells for Hematologic Diseases
Base editors, developed from the CRISPR/Cas system, consist of components such as deaminase and Cas variants. Since their emergence in 2016, the...
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Differential requirements for Smarca5 expression during hematopoietic stem cell commitment
The formation of hematopoietic cells relies on the chromatin remodeling activities of ISWI ATPase SMARCA5 (SNF2H) and its complexes. The Smarca5 null...
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Evaluating Histone Acetylation in Mouse Hematopoietic Stem and Progenitor Cells Using Chromatin Immunoprecipitation
Epigenetics is the study of how cells control gene activity without changing the DNA sequence. Various epigenetic processes have been identified,...
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Improving hematopoietic differentiation from human induced pluripotent stem cells by the modulation of Hippo signaling with a diarylheptanoid derivative
BackgroundThe diarylheptanoid ASPP 049 has improved the quality of adult hematopoietic stem cell (HSC) expansion ex vivo through long-term...
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Cigarette smoke impairs the hematopoietic supportive property of mesenchymal stem cells via the production of reactive oxygen species and NLRP3 activation
BackgroundMesenchymal stem cells (MSCs) play important roles in tissue homeostasis by providing a supportive microenvironmental niche for the...
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Fate-Map** of Hematopoietic Stem Cell-Derived Macrophages
Macrophages are cells of the innate immune system, which contribute to the maintenance of tissue homeostasis and form the first line of defense...
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Microplastics dampen the self-renewal of hematopoietic stem cells by disrupting the gut microbiota-hypoxanthine-Wnt axis
Microplastics (MPs) are contaminants ubiquitously found in the global biosphere that enter the body through inhalation or ingestion, posing...
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Functions and regulatory mechanisms of resting hematopoietic stem cells: a promising targeted therapeutic strategy
Hematopoietic stem cells (HSCs) are the common and essential precursors of all blood cells, including immune cells, and they are responsible for the...
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In vitro erythrocyte production using human-induced pluripotent stem cells: determining the best hematopoietic stem cell sources
BackgroundBlood transfusion is an essential part of medicine. However, many countries have been facing a national blood crisis. To address this...
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Utilizing CyTOF to Examine Hematopoietic Stem and Progenitor Phenotype
Regulation of hematopoiesis is dependent upon interactions between hematopoietic stem/progenitor cells and niche components, requiring a highly...
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Lentiviral Transduction of Nonhuman Primate Hematopoietic Stem and Progenitor Cells
The nonhuman primate (NHP) animal model is an important predictive preclinical model for develo** gene and cell therapies. It is also an...
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Deep learning-based predictive classification of functional subpopulations of hematopoietic stem cells and multipotent progenitors
BackgroundHematopoietic stem cells (HSCs) and multipotent progenitors (MPPs) play a pivotal role in maintaining lifelong hematopoiesis. The...
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Chromatin accessibility and cell cycle progression are controlled by the HDAC-associated Sin3B protein in murine hematopoietic stem cells
BackgroundBlood homeostasis requires the daily production of millions of terminally differentiated effector cells that all originate from...
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Generation of allogeneic CAR-NKT cells from hematopoietic stem and progenitor cells using a clinically guided culture method
Cancer immunotherapy with autologous chimeric antigen receptor (CAR) T cells faces challenges in manufacturing and patient selection that could be...
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Reversing the Aged Immune System with Stem Cells
The growing application for stem cells in medicine brings up the question of their role in aging and, to answer, how the information can be used to...