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A new Plasmodium vivax reference genome for South American isolates
BackgroundPlasmodium vivax is the second most important cause of human malaria worldwide, and accounts for the majority of malaria cases in South...
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Histone modifications associated with gene expression and genome accessibility are dynamically enriched at Plasmodium falciparum regulatory sequences
BackgroundThe malaria parasite Plasmodium falciparum has an unusually euchromatic genome with poorly conserved positioning of nucleosomes in...
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Plasmodium falciparum is evolving to escape malaria rapid diagnostic tests in Ethiopia
In Africa, most rapid diagnostic tests (RDTs) for falciparum malaria recognize histidine-rich protein 2 antigen. Plasmodium falciparum parasites...
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Gametocyte-specific and all-blood-stage transmission-blocking chemotypes discovered from high throughput screening on Plasmodium falciparum gametocytes
Blocking Plasmodium falciparum human-to-mosquito transmission is essential for malaria elimination, nonetheless drugs killing the pathogenic asexual...
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Gramtools enables multiscale variation analysis with genome graphs
Genome graphs allow very general representations of genetic variation; depending on the model and implementation, variation at different...
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A genoty** assay to determine geographic origin and transmission potential of Plasmodium falciparum malaria cases
As countries work towards malaria elimination, it is important to monitor imported cases to prevent reestablishment of local transmission. The Plasmodi...
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The power and promise of genetic map** from Plasmodium falciparum crosses utilizing human liver-chimeric mice
Genetic crosses are most powerful for linkage analysis when progeny numbers are high, parental alleles segregate evenly and numbers of inbred progeny...
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Malaria Parasite Plasmodium falciparum Proteins on the Surface of Infected Erythrocytes as Targets for Novel Drug Discovery
AbstractSpecific adhesion (sequestration) of Plasmodium falciparum parasite-infected erythrocytes (IEs) in deep vascular beds can cause severe...
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Chromosome-level genome assembly of Babesia caballi reveals diversity of multigene families among Babesia species
BackgroundBabesia caballi is an intraerythrocytic parasite from the phylum Apicomplexa, capable of infecting equids and causing equine...
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New investigation of encoding secondary metabolites gene by genome mining of a marine bacterium, Pseudoalteromonas viridis BBR56
Pseudoalteromonas viridis strain BBR56 was isolated from seawater at Dutungan Island, South Sulawesi, Indonesia. Bacterial DNA was isolated using...
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Variation in terpenoids in leaves of Artemisia annua grown under different LED spectra resulting in diverse antimalarial activities against Plasmodium falciparum
BackgroundProductivities of bioactive compounds in high-value herbs and medicinal plants are often compromised by uncontrollable environmental...
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An essential vesicular-trafficking phospholipase mediates neutral lipid synthesis and contributes to hemozoin formation in Plasmodium falciparum
BackgroundPlasmodium falciparum is the pathogen responsible for the most devastating form of human malaria. As it replicates asexually in the...
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Cyclical regression covariates remove the major confounding effect of cyclical developmental gene expression with strain-specific drug response in the malaria parasite Plasmodium falciparum
BackgroundThe cyclical nature of gene expression in the intraerythrocytic development cycle (IDC) of the malaria parasite, Plasmodium falciparum ,...
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Genome sequence of Ophryocystis elektroscirrha, an apicomplexan parasite of monarch butterflies: cryptic diversity and response to host-sequestered plant chemicals
Apicomplexa are ancient and diverse organisms which have been poorly characterized by modern genomics. To better understand the evolution and...
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Decoding the impact of nuclear organization on antigenic variation in parasites
Antigenic variation as a strategy to evade the host adaptive immune response has evolved in divergent pathogens. Antigenic variation involves...
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MalariaSED: a deep learning framework to decipher the regulatory contributions of noncoding variants in malaria parasites
Malaria remains one of the deadliest infectious diseases. Transcriptional regulation effects of noncoding variants in this unusual genome of malaria...
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Microalgae and Cyanobacteria: A Potential Source for Drug Discovery Using Genome Mining Approach
Drug discovery has been one of the most widely studied areas of research in the field of science and technology; a new disease has been emerging...
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Of membranes and malaria: phospholipid asymmetry in Plasmodium falciparum-infected red blood cells
Malaria is a vector-borne parasitic disease with a vast impact on human history, and according to the World Health Organisation, Plasmodium parasites...
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H3K36 methylation reprograms gene expression to drive early gametocyte development in Plasmodium falciparum
BackgroundThe Plasmodium sexual gametocyte stages are the only transmissible form of the malaria parasite and are thus responsible for the continued...
