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BRAFV600E-mutated serrated colorectal neoplasia drives transcriptional activation of cholesterol metabolism
BRAF mutations occur early in serrated colorectal cancers, but their long-term influence on tissue homeostasis is poorly characterized. We...
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Comparative roadmaps of reprogramming and oncogenic transformation identify Bcl11b and Atoh8 as broad regulators of cellular plasticity
Coordinated changes of cellular plasticity and identity are critical for pluripotent reprogramming and oncogenic transformation. However, the...
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Network Pharmacology-Based Prediction and Verification of Flavonoids from Elsholtiza densa Benth. for Treating Cervical Cancer
AbstractObjective: Elsholtzia , as a folk medicine, has been widely used in Miao, Yi, and Lahu nationalities and Tibetan and Chinese medicines in...
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Single-cell analysis reveals the stromal dynamics and tumor-specific characteristics in the microenvironment of ovarian cancer
High-grade serous ovarian carcinoma (HGSOC) is a heterogeneous disease, and a highstromal/desmoplastic tumor microenvironment (TME) is associated...
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PD-1 instructs a tumor-suppressive metabolic program that restricts glycolysis and restrains AP-1 activity in T cell lymphoma
The PDCD1 -encoded immune checkpoint receptor PD-1 is a key tumor suppressor in T cells that is recurrently inactivated in T cell non-Hodgkin...
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Expression and function of FRA1 protein in tumors
AP-1 is a dimeric complex that is composed of JUN, FOS, ATF and MAF protein families. FOS-related antigen 1 (FRA1) which encoded by FOSL1 gene,...
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Dual function of SF3B2 on chromatin and RNA to regulate transcription in head and neck squamous cell carcinoma
RNA is spliced concomitantly with transcription and the process is organized by RNA splicing factors, transcriptional regulators, and chromatin...
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Study on the Mechanisms of Banxia **exin Decoction in Treating Diabetic Gastroparesis Based on Network Pharmacology
In China, Banxia **exin decoction (BXD) is applied to treat diabetic gastroparesis (DGP), but its key active ingredients and mechanisms against DGP...
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Histone H3.3 K27M chromatin functions implicate a network of neurodevelopmental factors including ASCL1 and NEUROD1 in DIPG
BackgroundThe histone variant H3.3 K27M mutation is a defining characteristic of diffuse intrinsic pontine glioma (DIPG)/diffuse midline glioma...
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Patterns of enrichment and acceleration in evolutionary rates of promoters suggest a role of regulatory regions in cetacean gigantism
BackgroundCetaceans (whales, porpoises, and dolphins) are a lineage of aquatic mammals from which some species became giants. Only recently,...
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Emerging roles of circular RNAs in nasopharyngeal carcinoma: functions and implications
Nasopharyngeal carcinoma (NPC) is a distinct malignancy primarily prevalent in Southern China and Southeast Asia. Circular RNAs (circRNAs), a class...
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Super-enhancers and the super-enhancer reader BRD4: tumorigenic factors and therapeutic targets
Transcriptional super-enhancers and the BET bromodomain protein BRD4 are emerging as critical drivers of tumorigenesis and therapeutic targets....
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Maternal Undernutrition Induces Cell Signalling and Metabolic Dysfunction in Undifferentiated Mouse Embryonic Stem Cells
Peri-conceptional environment can induce permanent changes in embryo phenotype which alter development and associate with later disease...
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Transcriptomic analysis of intestinal organoids, derived from pigs divergent in feed efficiency, and their response to Escherichia coli
BackgroundThere is increasing interest in using intestinal organoids to study complex traits like feed efficiency (FE) and host-microbe interactions....
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Transcription factor networks in trophoblast development
The placenta sustains embryonic development and is critical for a successful pregnancy outcome. It provides the site of exchange between the mother...
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Comprehensive epigenomic profiling of human alveolar epithelial differentiation identifies key epigenetic states and transcription factor co-regulatory networks for maintenance of distal lung identity
BackgroundDisruption of alveolar epithelial cell (AEC) differentiation is implicated in distal lung diseases such as chronic obstructive pulmonary...
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Crosstalk between macrophages and cardiac cells after myocardial infarction
Cardiovascular diseases, such as myocardial infarction (MI), are a leading cause of death worldwide. Acute MI (AMI) inflicts massive injury to the...
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Pan-cancer predictions of transcription factors mediating aberrant DNA methylation
BackgroundAberrant DNA methylation is a hallmark of cancer cells. However, the mechanisms underlying changes in DNA methylation remain elusive....
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SWIM tool application to expression data of glioblastoma stem-like cell lines, corresponding primary tumors and conventional glioma cell lines
BackgroundIt is well-known that glioblastoma contains self-renewing, stem-like subpopulation with the ability to sustain tumor growth. These cells –...
