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Showing 21-40 of 103 results

  1. Motif-driven interactions between RNA and PRC2 are rheostats that regulate transcription elongation

    Although polycomb repressive complex 2 (PRC2) is now recognized as an RNA-binding complex, the full range of binding motifs and why PRC2–RNA...

    Michael Rosenberg, Roy Blum, ... Jeannie T. Lee in Nature Structural & Molecular Biology
    Article 04 January 2021

  2. Cartilage Repair by Mesenchymal Stem Cell-Derived Exosomes: Preclinical and Clinical Trial Update and Perspectives

    Osteoarthritis (OA) and other degenerative joint diseases are characterized by articular cartilage destruction, synovial inflammation, sclerosis of...
    Leila Taghiyar, Shahrbano Jahangir, ... Mohamadreza Baghaban Eslaminejad in Cell Biology and Translational Medicine, Volume 12
    Chapter 2021

  3. Replication dynamics identifies the folding principles of the inactive X chromosome

    Chromosome-wide late replication is an enigmatic hallmark of the inactive X chromosome (**). How it is established and what it represents remains...

    Rawin Poonperm, Saya Ichihara, ... Ichiro Hiratani in Nature Structural & Molecular Biology
    Article Open access 10 August 2023

  4. Three-dimensional in vitro culture models in oncology research

    Cancer is a multifactorial disease that is responsible for 10 million deaths per year. The intra- and inter-heterogeneity of malignant tumors make it...

    Camille Jubelin, Javier Muñoz-Garcia, ... Dominique Heymann in Cell & Bioscience
    Article Open access 11 September 2022

  5. UTX/KDM6A suppresses AP-1 and a gliogenesis program during neural differentiation of human pluripotent stem cells

    Background

    UTX/KDM6A is known to interact and influence multiple different chromatin modifiers to promote an open chromatin environment to facilitate...

    Beisi Xu, Brett Mulvey, ... Jamy C. Peng in Epigenetics & Chromatin
    Article Open access 25 September 2020

  6. Measuring the elastic modulus of soft culture surfaces and three-dimensional hydrogels using atomic force microscopy

    Growing interest in exploring mechanically mediated biological phenomena has resulted in cell culture substrates and 3D matrices with variable...

    Michael D. A. Norman, Silvia A. Ferreira, ... Eileen Gentleman in Nature Protocols
    Article 14 April 2021

  7. Biomechanical Characterization of Human Pluripotent Stem Cell-Derived Cardiomyocytes by Use of Atomic Force Microscopy

    Atomic force microscopy (AFM) is not only a high-resolution imaging technique but also a sensitive tool able to study biomechanical properties of...
    Jan Pribyl, Martin Pešl, ... Vladimir Rotrekl in Atomic Force Microscopy
    Protocol 2019

  8. A 3D model of a human epiblast reveals BMP4-driven symmetry breaking

    Breaking the anterior–posterior symmetry in mammals occurs at gastrulation. Much of the signalling network underlying this process has been...

    Mijo Simunovic, Jakob J. Metzger, ... Eric D. Siggia in Nature Cell Biology
    Article 01 July 2019

  9. Engineering of human cardiac muscle electromechanically matured to an adult-like phenotype

    The application of tissue-engineering approaches to human induced pluripotent stem (hiPS) cells enables the development of physiologically relevant...

    Kacey Ronaldson-Bouchard, Keith Yeager, ... Gordana Vunjak-Novakovic in Nature Protocols
    Article 06 September 2019

  10. Nanoparticles as Anti-inflammatory and Pro-regenerative Therapeutic Molecules

    The saying ‘size matters’ is the basis of the revolutionary technology that has taken this decade by storm. Nano-sized particles, on account of their...
    Ena Ray Banerjee in Perspectives in Translational Research in Life Sciences and Biomedicine
    Chapter 2017

  11. Discovering monotonic stemness marker genes from time-series stem cell microarray data

    Background

    Identification of genes with ascending or descending monotonic expression patterns over time or stages of stem cells is an important issue...

    Hsei-Wei Wang, Hsing-Jen Sun, ... I-Fang Chung in BMC Genomics
    Article Open access 21 January 2015

  12. Formation of Embryoid Bodies from Human Pluripotent Stem Cells Using AggreWell™ Plates

    Many human embryonic stem (hES) and induced pluripotent stem (hiPS) cell differentiation protocols begin with the formation of three-dimensional...
    Jennifer Antonchuk in Basic Cell Culture Protocols
    Protocol 2013

  13. Wnt signaling controls the specification of definitive and primitive hematopoiesis from human pluripotent stem cells

    Efforts to derive hematopoietic stem cells (HSCs) from human pluripotent stem cells (hPSCs) are complicated by the fact that embryonic hematopoiesis...

    Christopher M Sturgeon, Andrea Ditadi, ... Gordon Keller in Nature Biotechnology
    Article 18 May 2014

  14. Techniques in Embryoid Body Formation from Human Pluripotent Stem Cells

    Embryoid bodies (EBs) can be generated by culturing human pluripotent stem cells in ultra-low attachment culture vessels, under conditions that are...
    Nirupama K. Shevde, Amber A. Mael in Basic Cell Culture Protocols
    Protocol 2013

  15. A novel perfused rotary bioreactor for cardiomyogenesis of embryonic stem cells

    Developments in bioprocessing technology play an important role for overcoming challenges in cardiac tissue engineering. To this end, our laboratory...

    Ailing Teo, Athanasios Mantalaris, ... Mayasari Lim in Biotechnology Letters
    Article 21 March 2014

  18. Directed differentiation of embryonic origin–specific vascular smooth muscle subtypes from human pluripotent stem cells

    Vascular smooth muscle cells (SMCs) arise from diverse developmental origins. Regional distribution of vascular diseases may, in part, be attributed...

    Christine Cheung, Andreia S Bernardo, ... Sanjay Sinha in Nature Protocols
    Article 27 March 2014

  19. 20th International Chromosome Conference (ICCXX)

    Darren K. Griffin, Katie E. Fowler, ... Dean A. Jackson in Chromosome Research
    Article 23 January 2015

  20. Analysis of the Mitochondrial DNA and Its Replicative Capacity in Induced Pluripotent Stem Cells

    The mitochondrial genome resides in the mitochondrion of nearly all mammalian cells. It is important for energy production as it encodes 13 of the...
    Gael Cagnone, Vijesh Vaghjiani, ... Justin C. St.John in Induced Pluripotent Stem (iPS) Cells
    Protocol 2014
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