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Epigenetics and DNA Methylation
Epigenetics is a wide term representing molecular processes leading to modification of gene expression without bringing any DNA base sequence...
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Single-molecule long-read methylation profiling reveals regional DNA methylation regulated by Elongator Complex Subunit 2 in Arabidopsis roots experiencing spaceflight
BackgroundThe Advanced Plant Experiment-04 - Epigenetic Expression (APEX-04-EpEx) experiment onboard the International Space Station examined the...
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Proteins That Read DNA Methylation
Covalent modification of DNA via deposition of a methyl group at the 5′ position on cytosine residues alters the chemical groups available for...
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The Role of DNA Methylation in Zebrafish Models of CNS Diseases
AbstractDNA methylation plays an important role in the regulation of gene expression. Its deficits in the brain cause various neurological diseases,...
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DNA methylation rates scale with maximum lifespan across mammals
DNA methylation rates have previously been found to broadly correlate with maximum lifespan in mammals, yet no precise relationship has been...
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MBD2 couples DNA methylation to transposable element silencing during male gametogenesis
DNA methylation is an essential component of transposable element (TE) silencing, yet the mechanism by which methylation causes transcriptional...
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DNA methylation variations underlie lettuce domestication and divergence
BackgroundLettuce ( Lactuca sativa L. ) is an economically important vegetable crop worldwide. Lettuce is believed to be domesticated from a single...
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Age-Related Variation in DNA Methylation
Methylation is a ubiquitous, naturally occurring biochemical modification of DNA in mammalian cells that regulates gene expression. DNA methylation...
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Universal DNA methylation age across mammalian tissues
Aging, often considered a result of random cellular damage, can be accurately estimated using DNA methylation profiles, the foundation of pan-tissue...
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DNA methylation restricts coordinated germline and neural fates in embryonic stem cell differentiation
As embryonic stem cells (ESCs) transition from naive to primed pluripotency during early mammalian development, they acquire high DNA methylation...
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Important role of DNA methylation hints at significant potential in tuberculosis
Tuberculosis (TB), an infectious disease caused by Mycobacterium tuberculosis (Mtb) infection, has persisted as a major global public health threat...
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Altered DNA methylation and Dnmt expression in obese uterus may cause implantation failure
Obesity is defined by increased adipose tissue volume and has become a major risk factor for reproduction. Recent studies have revealed a substantial...
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DNA methylation: an emerging paradigm of gene regulation under drought stress in plants
Drought is an enormous threat to global crop production. In order to ensure food security for the burgeoning population, we must develop drought...
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Advances in DNA methylation and demethylation in medicinal plants: a review
DNA methylation and demethylation are widely acknowledged epigenetic phenomena which can cause heritable and phenotypic changes in functional genes...
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DNA methylation remodeling and the functional implication during male gametogenesis in rice
BackgroundEpigenetic marks are reprogrammed during sexual reproduction. In flowering plants, DNA methylation is only partially remodeled in the...
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Differential DNA methylation landscape of miRNAs genes in mice liver fibrosis
BackgroundPatients with chronic liver disease were found nearly all to have liver fibrosis, which is characterized by excess accumulation of...
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DNA methylation patterns of transcription factor binding regions characterize their functional and evolutionary contexts
BackgroundDNA methylation is an important epigenetic modification which has numerous roles in modulating genome function. Its levels are spatially...
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A novel approach toward optimal workflow selection for DNA methylation biomarker discovery
DNA methylation is a major epigenetic modification involved in many physiological processes. Normal methylation patterns are disrupted in many...
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Quantifying propagation of DNA methylation and hydroxymethylation with iDEMS
DNA methylation is a critical epigenetic mark in mammalian cells. Many aspects of DNA methylation maintenance have been characterized; however, the...
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Getting the chronological age out of DNA: using insights of age-dependent DNA methylation for forensic DNA applications
BackgroundDNA analysis for forensic investigations has a long tradition with important developments and optimizations since its first application....
