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RMI1 facilitates repair of ionizing radiation–induced DNA damage and maintenance of genomic stability
Ionizing radiation (IR) causes a wide variety of DNA lesions, of which DNA double-stranded breaks (DSBs) are the most deleterious. Homologous...
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ERCC1 abundance is an indicator of DNA repair-apoptosis decision upon DNA damage
DNA repair is essential for successful propagation of genetic material and fidelity of transcription. Nucleotide excision repair (NER) is one of the...
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Differential cellular localization of DNA gyrase and topoisomerase IB in response to DNA damage in Deinococcus radiodurans
Topoisomerases are crucial enzymes in genome maintenance that modulate the topological changes during DNA metabolism. Deinococcus radiodurans , a...
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Loss of p53 function promotes DNA damage-induced formation of nuclear actin filaments
Tumor suppressor p53 plays a central role in response to DNA damage. DNA-damaging agents modulate nuclear actin dynamics, influencing cell behaviors;...
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KIN17 functions in DNA damage repair and chemosensitivity by modulating RAD51 in hepatocellular carcinoma
The limited response of hepatocellular carcinoma (HCC) to chemotherapy drugs has always been a bottleneck in therapy. DNA damage repair is a major...
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Organophosphate pesticide-induced toxicity through DNA damage and DNA repair mechanisms
Organophosphate pesticides (OPs) are widely used in agriculture, healthcare, and other industries due to their ability to kill pests. However, OPs...
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DNA-PKcs regulates myogenesis in an Akt-dependent manner independent of induced DNA damage
Skeletal muscle regeneration relies on muscle stem (satellite) cells. We previously demonstrated that satellite cells efficiently and accurately...
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Mechanistic insights into DNA damage recognition and checkpoint control in plants
The plant DNA damage response (DDR) pathway safeguards genomic integrity by rapid recognition and repair of DNA lesions that, if unrepaired, may...
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Ataxia Telengectesia Protein Influences Bleomycin-Induced DNA Damage in Human Fibroblast Cells
Human cancer is caused mainly by exposure to genotoxic chemicals; therefore, cellular defence mechanisms against genotoxic stress are crucial....
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NPAS2 dampens chemo-sensitivity of lung adenocarcinoma cells by enhancing DNA damage repair
Chemotherapeutic agents, including cisplatin, have remained a cornerstone of lung adenocarcinoma (LUAD) treatment and continue to play an essential...
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ATM phosphorylates PP2A subunit A resulting in nuclear export and spatiotemporal regulation of the DNA damage response
Ataxia telangiectasia mutated (ATM) is a serine–threonine protein kinase and important regulator of the DNA damage response (DDR). One critical ATM...
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Ataxia telangiectasia and Rad3-related (ATR) inhibition by VE-822 potently reversed 5-flourouracil resistance in colorectal cancer cells through targeting DNA damage response
BackgroundVE-822 is a novel inhibitor of ATR, a key kinase involved in the DNA damage response pathway. The role of ATR inhibition in reversing drug...
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Calculation of Radiation-Induced DNA Damage Efficiency: Analysis of Uncertainties
Abstract —Computer simulations of the DNA damage are widely used due to their large application area. The computational methods to predict DNA breaks...
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Tissue-specific DNA damage response in Mouse Whole-body irradiation
BackgroundGenomic instability is a hallmark of various cancers, and DNA repair is an essential process for maintaining genomic integrity. Mammalian...
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MLK4 regulates DNA damage response and promotes triple-negative breast cancer chemoresistance
Chemoresistance constitutes a major challenge in the treatment of triple-negative breast cancer (TNBC). Mixed-Lineage Kinase 4 (MLK4) is frequently...
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Poly(ADP-ribosyl)ation of acetyltransferase NAT10 by PARP1 is required for its nucleoplasmic translocation and function in response to DNA damage
BackgroundN-acetyltransferase 10 (NAT10), an abundant nucleolar protein with both lysine and RNA cytidine acetyltransferase activities, has been...
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SCML2 contributes to tumor cell resistance to DNA damage through regulating p53 and CHK1 stability
SCML2 has been found to be highly expressed in various tumors. However, the extent to which SCML2 is involved in tumorigenesis and cancer therapy is...
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Targeting OGG1 and PARG radiosensitises head and neck cancer cells to high-LET protons through complex DNA damage persistence
Complex DNA damage (CDD), containing two or more DNA lesions within one or two DNA helical turns, is a signature of ionising radiation (IR) and...
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Ionizing radiation triggers mitophagy to enhance DNA damage in cancer cells
Radiotherapy is an important cancer treatment strategy that causes DNA damage in tumor cells either directly or indirectly. Autophagy is a...
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Multimerin 1 aids in the progression of ovarian cancer possibly via modulation of DNA damage response and repair pathways
Ovarian cancer is one of the leading causes of deaths among women. Despite advances in the treatment regimes, a high rate of diagnosis in the...
