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TRAIL receptors promote constitutive and inducible IL-8 secretion in non-small cell lung carcinoma
Interleukin-8 (IL-8/CXCL8) is a pro-angiogenic and pro-inflammatory chemokine that plays a role in cancer development. Non-small cell lung carcinoma...
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SARS-CoV-2 Receptors and Their Involvement in Cell Infection
AbstractThe new coronavirus infection (COVID-19) pandemic caused by SARS-CoV-2 has many times surpassed the epidemics caused by SARS-CoV and...
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Chemokine CCL2 and Its Receptor CCR2 in Regulation of Cognitive Functions and in Development of Aging Diseases
Data are presented on a special group of cytokine proteins called chemokines, whose major and most important function is to stimulate the migration...
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Crosstalk between purinergic receptor P2Y11 and chemokine receptor CXCR7 is regulated by CXCR4 in human macrophages
P2Y 11 is a G protein-coupled ATP receptor that activates IL-1 receptor (IL-1R) in a cyclic AMP dependent manner. In human macrophages, P2Y 11 /IL-1R...
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Allosteric Sites and Allosteric Regulators of G Protein-Coupled Receptors: Gray Cardinals of Signal Transduction
AbstractMembrane G protein-coupled receptors (GPCRs) are key components of most eukaryotic signaling systems, transducing external signals to...
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Stimulation of the atypical chemokine receptor 3 (ACKR3) by a small-molecule agonist attenuates fibrosis in a preclinical liver but not lung injury model
Atypical chemokine receptor 3 (ACKR3, formerly CXC chemokine receptor 7) is a G protein-coupled receptor that recruits β-arrestins, but is devoid of...
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Severe COVID-19-associated variants linked to chemokine receptor gene control in monocytes and macrophages
Genome-wide association studies have identified 3p21.31 as the main risk locus for severe COVID-19, although underlying mechanisms remain elusive. We...
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Rational Design of Drugs Targeting G-Protein-Coupled Receptors: A Structural Biology Perspective
AbstractG protein-coupled receptors (GPCRs) play a key role in the transduction of extracellular signals to cells and regulation of many biological...
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Chemokine signaling in cancer-stroma communications
Cancer is a multi-faceted disease in which spontaneous mutation(s) in a cell leads to the growth and development of a malignant new organ that if...
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Integrins as Receptors for Bacterial and Viral Pathogens
Integrins are important cell surface receptors named cell adhesion molecules that mediate cell–cell, cell–matrix, and cell–pathogen interactions....
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Involvement of ischemia-driven 5-lipoxygenase-resolvin-E1-chemokine like receptor-1 axis in the resolution of post-coronary artery bypass graft inflammation in coronary arteries
AimsExpression status of pro-resolvin lipid mediators (PLM) and receptors in the post-Coronary artery bypass grafting (CABG) coronary arteries are...
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Effect of retained placenta and clinical mastitis on reproduction parameters, immune response, and steroidogenic receptors gene expression in postpartum crossbred dairy cows
The purpose of this study was to evaluate the effect of retained placenta (RP) and clinical mastitis (CM) on the reproductive efficiency of crossbred...
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Scavenger receptors in host defense: from functional aspects to mode of action
Scavenger receptors belong to a superfamily of proteins that are structurally heterogeneous and encompass the miscellaneous group of transmembrane...
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Effect of 21-Day Dry Immersion on Expression of Inborn Immunity Genes Associated with the Toll-Like Receptors of Signaling Pathways
AbstractExpression of inborn immunity genes was studied in 10 essentially healthy male subjects aged 24 to 32 years in a 21-day dry immersion (DI)...
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Innate Immunity Via Glycan-Binding Lectin Receptors
Recognition of glycans and transfer of information contained in the glycan structures are performed by carbohydrate-recognizing proteins of lectins...
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Protein Design Strategies for the Structural–Functional Studies of G Protein-Coupled Receptors
AbstractG protein-coupled receptors (GPCRs) are an important family of membrane proteins responsible for many physiological functions in human body....
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Toll-like receptors 2 and 4 stress signaling and sodium-glucose cotransporter-2 in kidney disease
Kidney disease is the 6th fastest-growing cause of death and a serious global health concern that urges effective therapeutic options. The...
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Dopamine receptors gene overexpression in the microenvironment of invasive gastric cancer and its potential implications
BackgroundGastric cancer (GC) is the fifth most common cancer worldwide and the most commonly diagnosed cancer in Iran. The nervous system provides...
