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Irradiation-induced hair graying in mice: an experimental model to evaluate the effectiveness of interventions targeting oxidative stress, DNA damage prevention, and cellular senescence
Hair graying, also known as canities or achromotrichia, is a natural phenomenon associated with aging and is influenced by external factors such as...
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Oxidative stress signalling
Oxidative stress arises from an imbalance in the generation and removal of reactive oxygen species (ROS) within cells. ROS are produced during...
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Gut microbiome of Crocodylus porosus and cellular stress: inhibition of nitric oxide, interleukin 1-beta, tumor necrosis factor-alpha, and prostaglandin E2 in cerebrovascular endothelial cells
Crocodiles are renowned for their resilience and capacity to withstand environmental stressors, likely influenced by their unique gut microbiome. In...
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Cell maturation influences the ability of hESC-RPE to tolerate cellular stress
BackgroundTransplantation of human pluripotent stem cell-derived retinal pigment epithelium (RPE) is an urgently needed treatment for the cure of...
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The role of the glycerol transporter channel Fps1p in cellular proteostasis during enhanced proteotoxic stress
AbstractIn response to osmotic shock, the components of high-osmolarity glycerol (HOG) pathway regulate the level of intracellular glycerol in yeast...
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Regulation of PPARγ/CPT-1 expression ameliorates cochlear hair cell injury by regulating cellular lipid metabolism and oxidative stress
This study aimed to investigate the protective effects of PPARγ/CPT-1 regulation on cisplatin-induced cochlear hair cell injury. The viability,...
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HERC2 deficiency activates C-RAF/MKK3/p38 signalling pathway altering the cellular response to oxidative stress
HERC2 gene encodes an E3 ubiquitin ligase involved in several cellular processes by regulating the ubiquitylation of different protein substrates....
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Cell Signaling Response Under Plants Stress
Stresses (mechanical, herbivore, and insect damage) are the major threats that reduce plant yield and productivity. These stresses adversely modify...
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Transmembrane potential, an indicator in situ reporting cellular senescence and stress response in plant tissues
BackgroundPlant cells usually sustain a stable membrane potential due to influx and/or efflux of charged ions across plasma membrane. With the growth...
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Stress Granules: Synthesis and Significance
Stress granules as indicated by name, are transient cytoplasmic structures formed in response to different kinds of stresses. These are found in...
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Plant Signaling and Response to Abiotic Stress
Plants are occasionally exposed to unfavorable or stressful conditions such as extreme temperature, drought, salinity, and heavy metals called...
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Molecular Signaling and Cellular Cross-Talk to Tackle Metal(loid) Stress: Decoding Plants’ Secret Saga of Survival
Environmental contamination by heavy metals and metalloids is a serious problem globally, which endangers the environmental quality and ecosystem...
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Histone H1.0 couples cellular mechanical behaviors to chromatin structure
Tuning of genome structure and function is accomplished by chromatin-binding proteins, which determine the transcriptome and phenotype of the cell....
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Precision genetic cellular models identify therapies protective against ER stress
Rare monogenic disorders often share molecular etiologies involved in the pathogenesis of common diseases. Congenital disorders of glycosylation...
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T-cell cellular stress and reticulocyte signatures, but not loss of naïve T lymphocytes, characterize severe COVID-19 in older adults
In children and younger adults up to 39 years of age, SARS-CoV-2 usually elicits mild symptoms that resemble the common cold. Disease severity...
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Mechanisms of Plant Response to Heat Stress: Recent Insights
This chapter provides an in-depth exploration of the impact of heat stress on plant responses and tolerance. It includes the critical role of small...
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The Role of Sestrins in the Regulation of the Cellular Response to Stress
AbstractThis review is devoted to the analysis of proteins of the sestrin family and their role in the response of cells to stress. The paper...
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Overview of Cell Signaling Response Under Plant Stress
Abiotic stress due to unfavorable environment and biotic stress due to pathogenic microbes causes oxidative damage to cellular macromolecules such as...
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Hypertension and cellular senescence
Essential or primary hypertension is a wordwide health problem. Elevated blood pressure (BP) is closely associated not only with increased...
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Cellular senescence of renal tubular epithelial cells in acute kidney injury
Cellular senescence represents an irreversible state of cell-cycle arrest during which cells secrete senescence-associated secretory phenotypes,...
