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The Mechanism of Stem Cell Aging
Stem cells have self-renewal ability and multi-directional differentiation potential. They have tissue repair capabilities and are essential for...
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Reversing the Aged Immune System with Stem Cells
The growing application for stem cells in medicine brings up the question of their role in aging and, to answer, how the information can be used to...
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Morbid Cell Status and Donor Age Significantly Alter Mesenchymal Stem Cell Functionality and Reparability
Bone marrow (BM)-derived mesenchymal stem cells (MSCs) differentiate into specialized tissues, including cardiomyocytes, endothelial cells, and...
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Targeting c-Myc with decoy oligodeoxynucleotide-loaded polycationic nanoparticles inhibits cell growth and induces apoptosis in cancer stem-like cells (NTERA-2)
BackgroundAn increase in cancer stem cell (CSC) populations and their resistance to common treatments could be a result of c-Myc...
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Non-tight Junction Functions of Claudin Proteins: Roles in Cell-Matrix Interactions and Stem Cell Regulations
Tight junctions (TJs) are the most apical components of the junctional complex in epithelial cells, and they play an essential role in maintaining...
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Improving Autologous Fat Grafting in Regenerative Surgery through Stem Cell-Assisted Lipotransfer
Autologous fat transplantation -i.e., lipofilling- has become a promising and popular technique in aesthetic and reconstructive surgery with several...
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The Potential of miR-21 in Stem Cell Differentiation and its Application in Tissue Engineering and Regenerative Medicine
MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are two important types of non-coding RNAs that are not translated into protein. These...
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Mesenchymal stem cell-derived exosomes as a new therapeutic strategy in the brain tumors
Brain tumors are one of the most mortal cancers, leading to many deaths among kids and adults. Surgery, chemotherapy, and radiotherapy are available...
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Mechanisms involved in hematopoietic stem cell aging
Hematopoietic stem cells (HSCs) undergo progressive functional decline over time due to both internal and external stressors, leading to aging of the...
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3D Cell Culture Techniques
To better understand human physiology and its development and pathological conditions, in vitro cell culture models are recognised as effective...
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Cancer Stem Cells
Cancer stem cells (CSC) are cancerous cells expressing stem cell like properties of self-renewal and differentiation and are now reported from almost...
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Identification of stem cell-related subtypes and risk scoring for gastric cancer based on stem genomic profiling
BackgroundAlthough numerous studies demonstrate the role of cancer stem cells in occurrence, recurrence, and distant metastases in gastric cancer...
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Mesenchymal stem cell-released oncolytic virus: an innovative strategy for cancer treatment
Oncolytic viruses (OVs) infect, multiply, and finally remove tumor cells selectively, causing no damage to normal cells in the process. Because of...
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High percentage of Cancer Stem cells in metastatic locations: Upregulation of cicBIRC6 in highly metastatic breast Cancer Subline
BackgroundMetastasis is a devastating complication of breast cancer. Cancer relapse and metastasis are associated with cancer stem cells. CicBIRC6 is...
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Cancer Stem Cells are Actually Stem Cells with Disordered Differentiation: the Monophyletic Origin of Cancer
Cancer stem cells (CSCs) play an important role in cancer development. Based on advancements in CSC research, we propose a monophyletic model of...
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Translational control of stem cell function
Stem cells are characterized by their ability to self-renew and differentiate into many different cell types. Research has focused primarily on how...
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MSC-Derived Exosomes: Advances in Cell-Free Therapy
Mesenchymal stem cells (MSCs)Mesenchymal stem cells (MSCs) are a rich source of bioactive molecules, which they secrete as a part of their paracrine...
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Cancer Stem Cell Division: Mathematical Models and Insights
Purpose of ReviewTumors consist of heterogeneous cell types, which present challenges to effective therapeutics. This review intends to explore...
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Increased glucosylceramide production leads to decreased cell energy metabolism and lowered tumor marker expression in non-cancerous liver cells
Hepatocellular carcinoma (HCC) is one of the most difficult cancer types to treat. Liver cancer is often diagnosed at late stages and therapeutic...
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Comprehensive Review on the Effect of Stem Cells in Cancer Progression
Purpose of ReviewAdult stem cells play a pivotal role in the regeneration and revival of tissues that have been affected by aging or injury. Emerging...
