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Integrated analysis reveals FLI1 regulates the tumor immune microenvironment via its cell-type-specific expression and transcriptional regulation of distinct target genes of immune cells in breast cancer
BackgroundImmunotherapy is a practical therapeutic approach in breast cancer (BRCA), and the role of FLI1 in immune regulation has gradually been...
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Tumorigenic and tumoricidal properties of exosomes in cancers; a forward look
In recent decades, emerging data have highlighted the critical role of extracellular vesicles (EVs), especially (exosomes) Exos, in the progression...
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Cuproptosis: unveiling a new frontier in cancer biology and therapeutics
Copper plays vital roles in numerous cellular processes and its imbalance can lead to oxidative stress and dysfunction. Recent research has unveiled...
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Tissue engineering of human ear pinna
Auricular deformities (Microtia) can cause physical, social as well as psychological impacts on a patient’s wellbeing. Biofabrication of a complex...
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Nanoparticle-based approaches to target the lymphatic system for antitumor treatment
Immunotherapies have been established as safe and efficient modalities for numerous tumor treatments. The lymphatic system, which is an important...
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Killing tumor-associated bacteria with a liposomal antibiotic generates neoantigens that induce anti-tumor immune responses
Increasing evidence implicates the tumor microbiota as a factor that can influence cancer progression. In patients with colorectal cancer (CRC), we...
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Long-term differentiating primary human airway epithelial cell cultures: how far are we?
BackgroundHuman airway epithelial (HAE) cellular models are widely used in applicative studies of the airway physiology and disease. In vitro...
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Macrophage migration inhibitory factor family proteins are multitasking cytokines in tissue injury
The family of macrophage migration inhibitory factor (MIF) proteins in humans consist of MIF, its functional homolog D-dopachrome tautomerase (D-DT,...
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Susceptibility of cytoskeletal-associated proteins for tumor progression
The traditional functions of cytoskeletal-associated proteins (CAPs) in line with polymerization and stabilization of the cytoskeleton have evolved...
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Roles of exosomes in immunotherapy for solid cancers
Although immunotherapy has made breakthrough progress, its efficacy in solid tumours remains unsatisfactory. Exosomes are the main type of...
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Ferroptosis, radiotherapy, and combination therapeutic strategies
Ferroptosis, an iron-dependent form of regulated cell death driven by peroxidative damages of polyunsaturated-fatty-acid-containing phospholipids in...
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Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity
PTEN is a dual-specificity phosphatase that is frequently mutated in human cancer, and its deficiency in cancer has been associated with therapy...
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Merlin regulates signaling events at the nexus of development and cancer
BackgroundIn this review, we describe how the cytoskeletal protein Merlin, encoded by the Neurofibromin 2 ( NF2 ) gene, orchestrates developmental...
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Targeting the Key Signaling Pathways in Breast Cancer Treatment Using Natural Agents
Among the many leading types of cancers, breast cancer is placed second, affecting women globally and causing higher morbidity and mortality. Many...
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Physiological functions of SPP/SPPL intramembrane proteases
Intramembrane proteolysis describes the cleavage of substrate proteins within their hydrophobic transmembrane segments. Several families of...
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The Chaperokine Activity of Heat Shock Proteins
Enhanced expression of intracellular heat shock proteins (HSP) primarily promotes protein chaperoning, transport and folding of naïve, aberrantly...
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Selected abstracts from the 26th Conference of the European Cell Death Organization (ECDO): Cell death in disease — from small molecules to translational medicine
Sponsorship: Publication of this supplement was sponsored by the Medical Research Council (MRC). All content was reviewed and approved by the...
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New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer
Epithelial–mesenchymal transition (EMT) is a cellular programme that is known to be crucial for embryogenesis, wound healing and malignant...
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Epithelial cell adhesion molecule overexpression regulates epithelial-mesenchymal transition, stemness and metastasis of nasopharyngeal carcinoma cells via the PTEN/AKT/mTOR pathway
Epithelial cell adhesion molecule (EpCAM) is known to be highly expressed in a variety of epithelial carcinomas, and it is involved in cell adhesion...
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MIF- and CD74-Dependent Mechanisms
CD74 is a type II cell surface protein that was previously shown to play a role in antigen presentation and as a receptor for the cytokine macrophage...