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Tissue Engineering with Compact Bone-Derived Cell Spheroids Enables Bone Formation around Transplanted Tooth
BACKGROUND:Although tooth transplantation is a desirable treatment option for congenital defects of permanent teeth in children, transplantation to a...
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NMP4, an Arbiter of Bone Cell Secretory Capacity and Regulator of Skeletal Response to PTH Therapy
The skeleton is a secretory organ, and the goal of some osteoporosis therapies is to maximize bone matrix output. Nmp4 encodes a novel transcription...
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Osteoclasts at Bone Remodeling: Order from Order
Osteoclasts are multinucleated bone-resorbing cells derived from the monocyte/macrophage lineage. The macrophage colony-stimulating factor/receptor...
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Silencing NTPDase3 activity rehabilitates the osteogenic commitment of post-menopausal stem cell bone progenitors
BackgroundEndogenously released adenine and uracil nucleotides favour the osteogenic commitment of bone marrow-derived mesenchymal stromal cells...
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Osteoinductive micro-nano guided bone regeneration membrane for in situ bone defect repair
BackgroundBiomaterials used in bone tissue engineering must fulfill the requirements of osteoconduction, osteoinduction, and osseointegration....
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Omega-3 PUFAs prevent bone impairment and bone marrow adiposity in mouse model of obesity
Obesity adversely affects bone and fat metabolism in mice and humans. Omega-3 polyunsaturated fatty acids (omega-3 PUFAs) have been shown to improve...
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Atypical cell death and insufficient matrix organization in long-bone growth plates from Tric-b-knockout mice
TRIC-A and TRIC-B proteins form homotrimeric cation-permeable channels in the endoplasmic reticulum (ER) and nuclear membranes and are thought to...
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The role of integrin family in bone metabolism and tumor bone metastasis
Integrins have been the research focus of cell-extracellular matrix adhesion (ECM) and cytokine receptor signal transduction. They are involved in...
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3D Bioprinting in Conjunction with Bone Marrow Mesenchymal Stem Cells for the Treatment of Bone Defects
Clinical management of bone defects remains a challenge. Currently, the principal therapeutic option is autologous or synthetic bone grafting....
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Production and Application of Mesenchymal Stem Cell Spheroids for Cartilage and Bone Regeneration
Introduction: Cartilage and bone tissues are widely utilized in regenerative medicine, especially in treating injured cartilage and bone. Some...
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Establishment and characterization of NCC-GCTB5-C1: a novel cell line of giant cell tumor of bone
Giant cell tumor of bone (GCTB), is a rare intermediate malignant bone tumor with high local infiltrative ability, and is genetically characterized...
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3′-Sialyllactose alleviates bone loss by regulating bone homeostasis
Osteoporosis is a common skeletal disease that results in an increased risk of fractures. However, there is no definitive cure, warranting the...
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Synovium-Derived Mesenchymal Stem Cell-Based Scaffold-Free Fibrocartilage Engineering for Bone–Tendon Interface Healing in an Anterior Cruciate Ligament Reconstruction Model
Background:Current tendon and ligament reconstruction surgeries rely on scar tissue healing which differs from native bone-to-tendon interface (BTI)...
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Non-bone-derived exosomes: a new perspective on regulators of bone homeostasis
Accumulating evidence indicates that exosomes help to regulate bone homeostasis. The roles of bone-derived exosomes have been well-described;...
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Outcomes of autologous bone marrow mononuclear cell administration in the treatment of neurologic sequelae in children with spina bifida
BackgroundTo evaluate the safety and efficacy of autologous bone marrow mononuclear cell (BMMNC) infusion in the management of neurological sequelae...
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A Cartilaginous Construct with Bone Collar Exerts Bone-Regenerative Property Via Rapid Endochondral Ossification
Three-dimensional clumps of mesenchymal stem cells (MSCs)/extracellular matrix (ECM) complexes (C-MSCs) can be implanted into tissue defects with no...
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Replicative Senescence in Human Embryo Bone Marrow MSCs is Characterized by Changes in Cell Motility and Subcellular Localization of Rac1 and RhoA GTPases
AbstractHuman mesenchymal stem cells (MSC) are widely used in biomedical technologies, so it is important to study changes in their characteristics...
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Relative influence on cell behaviors of osteoblasts seeded onto demineralized bone matrix with diverse particle size
Demineralized bone matrix (DBM) is a natural and collagen-based allogeneic bone graft material with good bioactivity and biocompatibility. However,...
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Bone marrow mesenchymal stem cell-derived exosomes loaded with miR-26a through the novel immunomodulatory peptide DP7-C can promote osteogenesis
PurposeAs small bioactive molecules, exosomes can deliver osteogenesis-related miRNAs to target cells and promote osteogenesis. This study aimed to...
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Interleukin-19 in Bone Marrow Contributes to Bone Loss Via Suppressing Osteogenic Differentiation Potential of BMSCs in Old Mice
BackgroundCellular senescence is an important process related to the pathogenic mechanism of different disorders, especially bone loss. During...
