Search
Search Results
-
Generation of proximal tubule-enhanced kidney organoids from human pluripotent stem cells
Kidney organoids derived from human pluripotent stem cells (hPSCs) are now being used as models of renal disease and nephrotoxicity screening....
-
Podocytes derived from human induced pluripotent stem cells: characterization, comparison, and modeling of diabetic kidney disease
BackgroundIn diabetic kidney disease, high glucose damages specialized cells called podocytes that filter blood in the glomerulus. In vitro culture...
-
Control of directionality of chromatin folding for the inter- and intra-domain contacts at the Tfap2c–Bmp7 locus
BackgroundContact domains of chromatin serve as a fundamental unit to regulate action of enhancers for target genes. Loo** between a pair of...
-
The role of serum-glucocorticoid regulated kinase 1 in reproductive viability: implications from prenatal programming and senescence
ObjectiveOrganisms and cellular viability are of paramount importance to living creatures. Disruption of the balance between cell survival and...
-
Genome-wide identification and structural analysis of the BMP gene family in Triplophysa dalaica
BackgroundBone morphogenetic proteins (BMPs ) are part of the transforming growth factor beta (TGF-β) superfamily and play crucial roles in bone...
-
TGF-β/SMAD signaling regulation of mesenchymal stem cells in adipocyte commitment
Adipocytes arising from mesenchymal stem cells (MSCs) requires MSC adipocyte commitment and differentiation of preadipocytes to mature adipocytes....
-
Age-related changes in the cartilage of the temporomandibular joint
Osteoarthritis (OA) of the knee is closely associated with aging; however, little is known about the age-related degeneration in the mandibular...
-
Myeloid CCN3 protects against aortic valve calcification
BackgroundCellular communication network factor 3 (CCN3) has been implicated in the regulation of osteoblast differentiation. However, it is not...
-
Comparative genomic studies on the TGF-β superfamily in blue whale
TGF- β supergene family has a wide range of physiological functions including cell adhesion, motility, proliferation, apoptosis, and differentiation....
-
A Senescence-Associated Secretory Phenotype of Bone Marrow Mesenchymal Stem Cells Inhibits the Viability of Breast Cancer Cells
Breast cancer, the most prevalent malignancy in women, often progresses to bone metastases, especially in older individuals. Dormancy, a critical...
-
Mesenchymal-to-epithelial transition of osteoblasts induced by Fam20c knockout
BackgroundFam20c is intimately related to tissue development and diseases. At present, it has been reported that Fam20c regulates the mineralization...
-
Biomarkers of the End-Stage Renal Disease Progression: Beyond the GFR
AbstractChronic kidney disease can progress to the end-stage renal disease (ESRD) characterized by a high risk of morbidity and mortality. ESRD...
-
Preliminary study on microR-148a and microR-10a in dermal papilla cells of Hu sheep
BackgroundHu sheep, a unique Chinese breed with high reproductive performance, are also well known for their rare white lambskin in China. The...
-
Impact of Dietary Selenium on Modulation of Expression of Several Non-Selenoprotein Genes Related to Key Ovarian Functions, Female Fertility, and Proteostasis: a Transcriptome-Based Analysis of the Aging Mice Ovaries
Female reproductive (ovarian) aging is characterized by a marked decline in quantity and quality of follicles and oocytes, as well as alterations in...
-
Adipogenesis of ear mesenchymal stem cells (EMSCs): adipose biomarker-based assessment of genetic variation, adipocyte function, and brown/brite differentiation
Ear mesenchymal stem cells (EMSCs) have been investigated to differentiate into adipocytes, chondrocytes, and muscle cells in vitro. However, the...
-
BMP7 plays a critical role in TMEM100-inhibited cell proliferation and apoptosis in mouse metanephric mesenchymal cells in vitro
Kidney mainly arises from the induction of metanephric mesenchymal cells (MM cells) and the ureteric bud (UB). Transmembrane protein-100 (Tmem100)...
-
Adipogenic effects of Ostreae Testa water extract on white adipocytes
BackgroundObesity and its associated diseases have become a concerning health issue not only in the middle-aged population but also in young children...
-
Bone Using Stem Cells for Maxillofacial Bone Disorders: A Systematic Review and Meta-analysis
Due to economic, cultural, environmental, and social factors, the prevalence of maxillofacial bone disorders varies in different parts of the world....
-
Absence of E2f1 Negates Pro-osteogenic Impacts of p21 Absence
Loss of p21 leads to increased bone formation post-injury; however, the mechanism(s) by which this occurs remains undetermined. E2f1 is downstream of p21...
-
LncRNA CRLM1 inhibits apoptosis and promotes metastasis through transcriptional regulation cooperated with hnRNPK in colorectal cancer
BackgroundColorectal liver metastases (CRLM) continue to have a low survival rate. The number of CRLM regulators and clinical indicators remains...
