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Electrochemical Analysis in Studying β-Amyloid Aggregation
Abstractβ-amyloid (Aβ) is comprised of a group of peptides formed as a result of cleavage of the amyloid precursor protein by secretases. Aβ...
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Aggregation Behavior of Amyloid Beta Peptide Depends Upon the Membrane Lipid Composition
Protein aggregation plays a crucial role in the development of several neurodegenerative diseases. It is important to understand the aggregation...
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CSF tau phosphorylation occupancies at T217 and T205 represent improved biomarkers of amyloid and tau pathology in Alzheimer’s disease
Cerebrospinal fluid (CSF) amyloid-β peptide (Aβ)42/Aβ40 and the concentration of tau phosphorylated at site 181 (p-tau181) are well-established...
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Haemorheologic Enhancement of Cerebral Perfusion Improves Oxygen Supply and Reduces Aβ Plaques Deposition in a Mouse Model of Alzheimer’s Disease
Alzheimer’s disease (AD) is a consequence of complex interactions of age-related neurodegeneration and vascular-associated pathologies, affecting...
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Amyloid peptides with antimicrobial and/or microbial agglutination activity
AbstractMicrobe (including bacteria, fungi, and virus) infection in brains is associated with amyloid fibril deposit and neurodegeneration....
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Vascular dysfunction occurs prior to the onset of amyloid pathology and Aβ plaque deposits colocalize with endothelial cells in the hippocampus of female APPswe/PSEN1dE9 mice
Increasing evidence shows that cardiovascular diseases (CVDs) are associated with an increased risk of cognitive impairment and Alzheimer’s diseases...
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Scallop-derived plasmalogen attenuates amyloid beta-induced inflammation and apoptosis in SH-SY5Y cells
BackgroundsWith an increase in the world’s aging population, candidate substances for the management of neurodegenerative diseases, including...
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Sustained meningeal lymphatic vessel atrophy or expansion does not alter Alzheimer’s disease-related amyloid pathology
Discovery of meningeal lymphatic vessels (LVs) in the dura mater, also known as dural LVs (dLVs) that depend on vascular endothelial growth factor C...
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Proteomics analysis of prefrontal cortex of Alzheimer’s disease patients revealed dysregulated proteins in the disease and novel proteins associated with amyloid-β pathology
BackgroundAlzheimer’s disease (AD) is a progressive, chronic, and neurodegenerative disease, and the most common cause of dementia worldwide....
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Amyloid-β mediates intestinal dysfunction and enteric neurons loss in Alzheimer's disease transgenic mouse
Alzheimer's disease (AD) is traditionally considered as a brain disorder featured by amyloid-β (Aβ) deposition. The current study on whether...
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Amyloid β accelerates age-related proteome-wide protein insolubility
Loss of proteostasis is a highly conserved feature of aging across model organisms and results in the accumulation of insoluble protein aggregates....
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Neuropathological and sociodemographic factors associated with the cortical amyloid load in aging and Alzheimer’s disease
Alzheimer’s disease (AD) is the leading cause of dementia and is characterized by a progressive decline in cognitive abilities. A pathological...
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Neoagarohexaose Protects against Amyloid β-Induced Oxidative Stress and Aggregation
AbstractAlzheimer’s disease (AD) is an age-related neurodegenerative disorder. Neuritic plaques containing amyloid-β protein (Aβ) and neurofibrillary...
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Repeated multi-domain cognitive training prevents cognitive decline, anxiety and amyloid pathology found in a mouse model of Alzheimer disease
Education, occupation, and an active lifestyle, comprising enhanced social, physical, and mental components are associated with improved cognitive...
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Hfq C-terminal region forms a β-rich amyloid-like motif without perturbing the N-terminal Sm-like structure
Hfq is a pleitropic actor that serves as stress response and virulence factor in the bacterial cell. To execute its multiple functions, Hfq assembles...
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G-protein coupled estrogen receptor 1, amyloid-β, and tau tangles in older adults
Accumulation of amyloid-β (Aβ) and tau tangles are hallmarks of Alzheimer’s disease. Aβ is extracellular while tau tangles are typically...
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Aβ efflux impairment and inflammation linked to cerebrovascular accumulation of amyloid-forming amylin secreted from pancreas
Impairment of vascular pathways of cerebral β-amyloid (Aβ) elimination contributes to Alzheimer disease (AD). Vascular damage is commonly associated...
