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Estimates of regeneration potential in the Pannonian sand region help prioritize ecological restoration interventions
Restoration prioritization helps determine optimal restoration interventions in national and regional spatial planning to create sustainable...
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Comparative genome-wide analysis of circular RNAs in Brassica napus L.: target-site versus non-target-site resistance to herbicide stress
Circular RNAs (circRNAs), a class of non-coding RNA molecules, are recognized for their unique functions; however, their responses to herbicide...
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Active layer dynamics drives a transition to biofilm fingering
The emergence of spatial organisation in biofilm growth is one of the most fundamental topics in biofilm biophysics and microbiology. It has long...
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Antibody and antibody fragments site-specific conjugation using new Q-tag substrate of bacterial transglutaminase
During the last few years Antibody-Drug Conjugates (ADCs) have become one of the most active and very promising therapeutic weapons. Lessons learned...
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COQ7 splice site variant causing a spastic paraparesis phenotype in siblings
The COQ7 gene is one of the causative genes for primary COQ10 deficiency-related disorders. OMIM-related phenotypes include severe...
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Conserved allosteric inhibitory site on the respiratory syncytial virus and human metapneumovirus RNA-dependent RNA polymerases
Respiratory syncytial virus (RSV) and human metapneumovirus (HMPV) are related RNA viruses responsible for severe respiratory infections and...
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Metallo-β-Lactamases: Influence of the Active Site Structure on the Mechanisms of Antibiotic Resistance and Inhibition
AbstractThe review focuses on bacterial metallo-β-lactamases (MβLs) responsible for the inactivation of β-lactams and associated antibiotic...
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Methane Cycle in a Littoral Site of a Temperate Freshwater Lake
Abstract —Eutrophication of lakes results in the intensification of anaerobic processes, including methanogenesis, and therefore in enhanced emission...
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Nanoencapsulation for Controlled Release of Active Components
Nanotechnology has become one of the most intriguing areas of scientific research and development. This cutting-edge technology focuses on nanoscale...
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Effect of soil depth on the structure of bacterial composition in the active layer at five geologically distinct sites on James Ross and Vega Islands in Antarctica
Microbial communities in the active layer play a crucial role in the biogeochemical cycles of Antarctic pristine ecosystems. Here, 16S rRNA gene...
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Microbes in porous environments: from active interactions to emergent feedback
Microbes thrive in diverse porous environments—from soil and riverbeds to human lungs and cancer tissues—spanning multiple scales and conditions....
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Rational design of stapled helical peptides as antidiabetic PPARγ antagonists to target coactivator site by decreasing unfavorable entropy penalty instead of increasing favorable enthalpy contribution
Peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-activated transcription factor belonging to the nuclear hormone receptor and has...
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Increase in the solubility of uvsY using a site saturation mutagenesis library for application in a lyophilized reagent for recombinase polymerase amplification
BackgroundRecombinase uvsY from bacteriophage T4, along with uvsX, is a key enzyme for recombinase polymerase amplification (RPA), which is used to...
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Calcinating Bacteria in Extreme Ecosystems of the Southern Aral Region
Abstract —The processes of microbially induced precipitation of calcium carbonates are widespread in natural environments and are an important part of...
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Site-directed modification of multifunctional lignocellulose-degrading enzymes of straw based on homologous modeling
Studying the straw lignocellulose strengthening mechanism during simultaneous degradation has important practical significance for improving resource...
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Site-specific photolabile roadblocks for the study of transcription elongation in biologically complex systems
Transcriptional pausing is crucial for the timely expression of genetic information. Biochemical methods quantify the half-life of paused RNA...
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Structural studies reveal flexible roof of active site responsible for ω-transaminase CrmG overcoming by-product inhibition
Amine compounds biosynthesis using ω-transaminases has received considerable attention in the pharmaceutical industry. However, the application of...
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Identification and functional characterisation of a locus for target site integration in Fusarium graminearum
BackgroundFusarium Head Blight (FHB) is a destructive floral disease of different cereal crops. The Ascomycete fungus Fusarium graminearum ( Fg ) is...
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Combined Use of Unidirectional Site-Specific Recombination System and CRISPR-Cas Systems for Plant Genome Editing
Site-specific recombination (SSR) systems have been extensively used for controlled genome modification in eukaryotic cells, especially for DNA...
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