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Give and Take: The Reciprocal Control of Metabolism and Cell Cycle
Cell cycle is an ordered sequence of events that occur in a cell preparing for cell...
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Design and synthesis of N-aryl-2-trifluoromethyl-quinazoline-4-amine derivatives as potential Werner-dependent antiproliferative agents
To discover new Werner (WRN) helicase inhibitors, a series of N -aryl-2-trifluoromethyl-quinazoline-4-amine derivatives were designed and synthesized...
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A comprehensive approach to phytochemical analysis of macromolecular composites that protect tubers: case studies in suberized potato periderm tissues
Terrestrial plants rely on protection conferred by their outer coverings to defend against desiccation, bruising, and microbial invasion. For food...
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Synthesis, Spectral Investigations, Biological Studies, and In Silico Approach of Vanillin Heterocyclic Acetamides
AbstractObjective: A sequence of biologically active vanillin acetamides bearing heterocyclic moiety (VHAs) specifically vanillin isoniazid...
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Asymmetric synthesis of spiro[4H-chromene-3,3′-oxindoles] via a squaramide-organocatalytic three-component cascade Knoevenagel/Michael/cyclization sequence
Asymmetric synthesis of spiro[4 H -chromene-3,3′-oxindole] derivatives was realized through an organocatalytic cascade Knoevenagel/Michael/cyclization...
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Site-Specific Isotope Labeling of FliG for Studying Structural Dynamics Using Nuclear Magnetic Resonance Spectroscopy
To understand flagella-driven motility of bacteria, it is important to understand the structure and dynamics of the flagellar motor machinery. We...
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Synthesis of Novel N-Acylhydrazones Derived from 3,5-Dinitrobenzohydrazide and Evaluation of Their Anticholinesterase and Antioxidant Activities
AbstractObjective: In this study, it was aimed to determine the antioxidant activities and enzyme inhibition properties of newly synthesized N- acylhy...
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Synthesis and Urease Inhibition Activities of Some New Schiff Bases Benzimidazoles Containing Thiophene Ring
AbstractObjective: Schiff bases are significant pharmacophores and show varied biological applications such as antiurease, antidiabetic,...
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Synthesis of cis-(8b,14a)-hexahydro-14H-dibenzo[f,h]oxazolo[3,2-b]isoquinolin-14-ones via photo cascade reaction
A concise method for the synthesis of cis-(8b,14a)-hexahydro-14H-dibenzo[f,h]oxazolo[3,2-b]isoquinolin-14-ones 2 via photo-induced...
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Contrasting packing modes for tubular assemblies in chlorosomes
The largest light-harvesting antenna in nature, the chlorosome, is a heterogeneous helical BChl self-assembly that has evolved in green bacteria to...
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Design, synthesis and bioactivity evaluation of novel monomethyl auristatin F analogues
Monomethyl auristatin F (MMAF), a synthetic analogue of the natural compound dolastatin 10, has garnered significant attention in cancer research due...
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Multicomponent synthesis of 3-(1H-indol-3-yl)-2-phenyl-1H-benzo[f]indole-4,9-dione derivatives
Herein, we report a one-pot greener methodology for the synthesis of 3-(1 H -indol-3-yl)-2-phenyl-1 H -benzo[ f ]indole-4,9-dione derivatives by the...
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Antiviral activity evaluation and action mechanism of chalcone derivatives containing phenoxypyridine
In this paper, a series of phenoxypyridine-containing chalcone derivatives ( L1 – L28 ) were designed and synthesized, characterized on NMR and HRMS....
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Design and synthesis of new quinazolinone derivatives: investigation of antimicrobial and biofilm inhibition effects
New quinazolin-4-ones 9–32 were synthesized in an attempt to overcome the life-threatening antibiotic resistance phenomenon. The antimicrobial...
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Design, Synthesis, and Anti-Tumor Activity Evaluation In Vitro of 4,6,7–Trisubstituted Quinazoline Derivatives Containing Acrylamide Group
AbstractObjective: In order to enrich the library of anti-tumor small molecule compounds, 19 compounds, with highly effective anti-tumor, have been...
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Design, Synthesis, In Silico Molecular Docking, ADMET Studies, and Biological Evaluation of Novel Substituted Diphenyl Pyrazole Incorporated 1,2,3-Triazolyl Benzene Sulfonamides
AbstractObjective: A novel triazolyl benzene sulfonamides were synthesized and evaluated for antitubercular and anticancer activity. Methods: Our...
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Structure-based inhibition of acetylcholinesterase and butyrylcholinesterase with 2-Aryl-6-carboxamide benzoxazole derivatives: synthesis, enzymatic assay, and in silico studies
An important research topic is the discovery of multifunctional compounds targeting different disease-causing components. This research aimed to...
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Design, synthesis and systemic acquired resistance of 2-benzothiadiazolylquinoline-4-carboxamides by COI1 based virtual screening
Coronatine-insensitive 1 (COI1) has been identified as a target receptor of plant elicitor coronatine (COR). To discover novel plant elicitor leads,...
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Design, synthesis and biological evaluation of 5H-[1,2,4]triazino[5,6-b]indole derivatives bearing a pyridinocycloalkyl moiety as iron chelators
The avidity of cancer cells for iron highlights the potential for iron chelators to be used in cancer therapy. Herein, we designed and synthesized a...
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Synthesis, Antibacterial, and Antifungal Evaluation of New Class of Pyrimido[4,5-d]pyrimidine, Pyrazolo[3,4-d]pyrimidine, and Pyrimido[4,5-b]quinoline Derived from α,α-Ketene Dithioacetals as fused Five and Six-membered Heterocycle Derivatives
AbstractA novel heterocyclic compounds containing pyrimido[4,5- d ]pyrimidine ( IIIa–IIIb ) and ( IVa–IVb ), pyrazolo[3,4- d ]pyrimidine ( Va'–Ve' ) and ( VIa'–VIe'...