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Transient receptor potential (TRP) protein 7 acts as a G protein-activated Ca2+ channel mediating angiotensin II-induced myocardial apoptosis
Transient receptor potential (TRP) proteins have been identified as cation channels that are activated by agonist–receptor coupling and mediate...
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STIM1 carboxyl-terminus activates native SOC, Icrac and TRPC1 channels
Receptor-evoked Ca 2+ signalling involves Ca 2+ release from the endoplasmic reticulum, followed by Ca 2+ influx across the plasma membrane
1 . Ca 2+ ...
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Involvement of ERK1/2 and p38 in Mg2+ accumulation in liver cells
Activation of PKC signaling induces Mg 2+ accumulation in liver cells. To test the hypothesis that PKC induces Mg 2+ accumulation via MAPKs activation,...
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Evidence for a Multistep Model for Eukaryotic Polyamine Transport
One of the most intriguing aspects of polyamine biology is the considerable diversity of their functions in the cell. The involvement of polyamines...
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Potential Roles of Electrogenic Ion Transport and Plasma Membrane Depolarization in Apoptosis
Apoptosis is characterized by the programmed activation of specific biochemical pathways leading to the organized demise of cells. To date, aspects...
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Transport of magnesium and other divalent cations: evolution of the 2-TM-GxN proteins in the MIT superfamily
In bacteria, magnesium uptake is mainly mediated by the well-characterized CorA type of membrane proteins. In recent years, functional homologues...
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Functionality of the TRPV subfamily of TRP ion channels: add mechano-TRP and osmo-TRP to the lexicon!
Transient receptor potential (TRP) ion channels have been identified as cellular sensors responding to diverse external and internal stimuli. This...
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The Nudix hydrolase superfamily
Nudix hydrolases are found in all classes of organism and hydrolyse a wide range of organic pyrophosphates, including nucleoside di- and...
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Identification and characterization of a novel mammalian Mg2+ transporter with channel-like properties
BackgroundIntracellular magnesium is abundant, highly regulated and plays an important role in biochemical functions. Despite the extensive evidence...
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Changes in the transcriptional profile of transporters in the intestine along the anterior-posterior and crypt-villus axes
BackgroundThe purpose of this work was to characterize the expression of drug and nutrient carriers along the anterior-posterior and crypt-villus...
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Protein phosphatases and their potential implications in neuroprotective processes
Several neurological disorders such as stroke, amyotrophic lateral sclerosis and epilepsy result from excitotoxic events and are accompanied by...
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Transport of nonessential metals across mammalian cell membranes
Nonessential metals are opportunistic. They compete with essential metals for binding to various cofactors, receptors, transcription factors,...
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Dependence of the resting [Ca2+]cyt of RBL-1 cells on Ca2+ entry
The cytoplasmic Ca 2+ concentration ([Ca 2+ ] cyt ) in resting cells in an equilibrium between several influx and efflux mechanisms. Here we address the...
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Distinct Ca2+-permeable Cation Currents Are Activated by Internal Ca2+-Store Depletion in RBL-2H3 Cells and Human Salivary Gland Cells, HSG and HSY
Store-operated Ca 2+ influx, suggested to be mediated via store-operated cation channel (SOC), is present in all cells. The molecular basis of SOC,...
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The TRPM7 channel is inactivated by PIP2 hydrolysis
TRPM7 (ChaK1, TRP-PLIK, LTRPC7) is a ubiquitous, calcium-permeant ion channel that is unique in being both an ion channel and a serine/threonine...
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The cellular and molecular basis of store-operated calcium entry
The impact of calcium signalling on so many areas of cell biology reflects the crucial role of calcium signals in the control of diverse cellular...
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TRPs Make Sense
Abstract
Drosophila flies with the trp mutation exhibit impaired vision due to the lack of a specific Ca 2+ influx pathway in the photoreceptors. The...