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Control of Protein Kinase C Function by Activators and Inhibitors
Ca2+- and phospholipid-dependent protein kinase (protein kinase C), discovered by’Nishizuka and associates in 1977 (Takai et al. 1977; Inoue et al....
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Prostaglandins (Eicosanoids) and Their Role in Ectothermic Organisms
Prostaglandins (PGs) are often mentioned in the context of mammalian physiology and pathophysiology. It is now known that PGs are present and play...
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Biosynthesis and Biological Activities of Lipoxin A5 and B5 from Eicosapentaenoic Acid
[1-14C]- Eicosapentaenoic acid (EPA) was incubated with porcine leukocytes. Three polar metabolites were isolated after RP-HPLC separation in...
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Lipoxin Syntheses by Arachidonate 12- and 5-Lipoxygenases Purified from Porcine Leukocytes
Recently, we were successful in the purification of 12-lipoxygenase1 and 5-lipoxygenase2 from porcine leukocytes by immunoaffinity chromatography...
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The Glomerular Physiology of Lipoxin-A
A number of renal diseases, such as acute and chronic glomerulonephritis, acute interstitial nephritis, allograft rejection, and others are...
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Phospholipase A2 Stimulated Release of Lipoxin B4 Formation from Endogenous Sources of Arachidonic Acid in Porcine Leukocytes
Incubation of an isoenzyme of phospholipase A2 (PLA2, isolated from snake venom) with porcine leukocytes resulted in the formation of several...
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Actions of Lipoxin A4 and Related Compounds in Smooth Muscle Preparations and on the Microcirculation in Vivo
The present chapter summarizes our findings with lipoxins (LX) in spasmogenic assays and in the intact microvasculature of the hamster cheek pouch....
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Computed Conformational Analysis of Lipoxins and Their Ionic Complexes
The possible molecular conformations of four structurally and biologically different lipoxins derivatives were predicted by a systematic structure...
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Lipoxygenase Catalyzed Oxygenation of Hydroxy Fatty Acids to Lipoxins
The pure lipoxygenases from rabbit reticulocytes and soybeans convert a variety of substrates (arachidonic acid, 15-HPETE, 15-HETE, 5-HETE, various...
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Effects of Lipoxins A and B on Functional Responses of Human Granulocytes
The effects of synthetic lipoxin A and B (LXA and LXB) as well as several of their isomers were assessed as inducers of functional responses of human...
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The Lipoxins: Synthesis and Biosynthesis
Since the first report of their isolation in 19841,2 the lipoxins have generated considerable interest amongst researchers studying the lipoxygenase...
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Lipoxins: A New Series of Eicosanoids (Biosynthesis, Stereochemistry, and Biological Activities)
The oxygenation of arachidonic acid and other polyunsaturated fatty acids by a wide variety of cell types results in the formation of several...
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Lipoxins of the 5-Series Derived from Eicosapentaenoic Acid
Arachidonic acid released from membrane phospholipids during cell activation is metabolised by the cyclo-oxygenase pathway to prostaglandins and...
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The Total Synthesis of the Lipoxins and Related Compounds
In 1984, a new class of arachidoníc acid derived products was discovered by Serhan et al.1–3 While studying lipoxygenase pathway interactions, these...
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The Structure and Function of Ca+2 - and Phospholipid- Dependent Protein Kinase (Protein Kinase C), A Trans-Membrane Signal Transducer
Ca+2- and phospholipid- dependent protein kinase (protein kinase c), first discovered by Nishizuka’s group as a protease-activated kinase in 1977...
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The Respiratory Burst and Cellular Ion Homeostasis
The respiratory burst of phagocytic cells uses electron transfer to produce a series of highly reactive toxic oxygen metabolites. This process is...
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Extraction and purification of arachidonic acid metabolites from cell cultures
The oxygenated, biologically active, metabolites of arachidonic acid (5,8,11,14-eicosatetraenoic acid), collectively called eicosanoids, include...
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Lipoxins
A variety of cells release and oxygenate arachidonic acid during their interaction with specific stimuli. In its nonesterified form, arachidonic acid...