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Secreted frizzled related protein 1 (Sfrp1) and Wnt signaling in innervated and denervated skeletal muscle
Wnts are secreted proteins with functions in differentiation, development and cell proliferation. Wnt signaling has also been implicated in...
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Age-dependent Wnt gene expression in bone and during the course of osteoblast differentiation
Wnt signaling is vital for osteoblast differentiation and recently has been associated with aging. Because impaired osteoblastogenesis is a cellular...
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Mesodermal fate decisions of a stem cell: the Wnt switch
Stem cells are a powerful resource for cell-based transplantation therapies in osteodegenerative disorders, but before some kinds of stem cells can...
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Wnt Signaling Mediates Diverse Developmental Processes in Zebrafish
A combination of forward and reverse genetic approaches in zebrafish has revealed novel roles for canonical Wnt and Wnt/PCP signaling during...
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Wnt Signaling in Cnidarians
Cnidarians are an ancient group of animals at the base of metazoan evolution. They exhibit a simple body plan with only one well-defined body axis...
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The Genetic Signature of Perineuronal Oligodendrocytes
Oligodendrocytes in the central nervous system can be categorized as precursors, myelin-forming, and non-myelinating perineuronal cells. The function...
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Networking of WNT, FGF, Notch, BMP, and Hedgehog Signaling Pathways during Carcinogenesis
The biological functions of some orthologs within the human genome and model-animal genomes are evolutionarily conserved, but those of others are...
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Effects of intermittent parathyroid hormone (PTH) administration on SOST mRNA and protein in rat bone
Sclerostin, the secreted protein product of the SOST gene, which is mainly expressed by osteocytes, has recently been proposed as a negative...
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The gastrointestinal tract stem cell niche
The gastrointestinal epithelium is unique in that cell proliferation, differentiation, and apoptosis occur in an orderly fashion along the...
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Integration of Signaling Pathways Via Smad Proteins
TGF-β ligands are involved in most aspects of embryonic development and post-natal homeostasis and numerous examples of crosstalk with other...
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Molecular complexity in establishing uterine receptivity and implantation
Implantation is the process by which the blastocyst comes into intimate physical and physiological contact with the uterine endometrium. This process...
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Peutz–Jeghers LKB1 mutants fail to activate GSK-3β, preventing it from inhibiting Wnt signaling
Peutz–Jeghers syndrome (PJS) is caused by germline mutations in the LKB1 gene, which encodes a serine-threonine kinase that regulates cell...
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Angiogenesis and signal transduction in endothelial cells
Endothelial cells receive multiple information from their environment that eventually leads them to progress along all the stages of the process of...
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The Frizzled family: receptors for multiple signal transduction pathways
Frizzled genes encode integral membrane proteins that function in multiple signal transduction pathways. They have been identified in diverse...
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The Wnts
The Wnt genes encode a large family of secreted protein growth factors that have been identified in animals from hydra to humans. In humans, 19 WNT...
