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Characterization of the murine polycystic kidney disease (
Pkd2 ) geneAutosomal dominant polycystic kidney disease (ADPKD) is one of the most frequent genetically transmitted disorders among Europeans with an...
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Selective and organotypic culture of intrahepatic bile duct cells from adult pig liver
Secondary culture of nontransformed bile duct epithelium has been difficult to achieve. STO feeder cell-dependent secondary cultures of adult pig...
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Influence of an extracellular volume expansion (ECVE) on renal amino acid- and sodium handling in patients with autosomal dominant polycystic kidney disease (ADPKD)
Although ADPKD is one of the first kidney diseases to be understood from the gene to the pathogenesis of clinical abnormalities, there were no data...
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Polycystin expression during embryonic development of human kidney in adult tissues and ADPKD tissue
Normal renal tissue, ranging from 8 weeks' gestation to full term to adult, was probed with polyclonal antibodies raised to peptide epitopes within...
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The mouse homolog of PKD1: Sequence analysis and alternative splicing
We have cloned and sequenced the mouse transcript homologous to human polycystic kidney disease 1 (PKD1). The predicted protein is 79% identical to...
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The Golgi apparatus in disease
As attested by the chapters in this book, the past fifteen years have witnessed impressive progress towards the understanding of the structure and... -
Growth characteristics of cells cultured from two murine models of polycystic kidney disease
Polycystic kidney disease (PKD) is characterized by multiple renal cysts that are lined by epithelium and filled with fluid. PKD may result from one...
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Future perspectives: molecular biology and pathophysiology
The role of epithelia in maintaining plasma homeostasis of electrolytes and non-electrolytes was reviewed in Chapter 1. This homeostasis is... -
Sequence analysis of the human hTg737 gene and its polymorphic sites in patients with autosomal recessive polycystic kidney disease
DNA sequence analysis of the human Tg737 gene was performed in 36 patients with the autosomal recessive form of polycystic kidney disease (ARPKD)....