Search
Search Results
-
Peptide Derivatives of Human and Rabbit Cathelicidin Reduce Inflammatory Cytokines in Peripheral Blood Mononuclear Cells of Rheumatoid Arthritis Patients
Peptides, as therapeutic agents, can mimic the actions of molecules involved in inflammatory disorders. Antimicrobial peptides (AMPs), generated by...
-
Reprogramming of human peripheral blood mononuclear cells into induced mesenchymal stromal cells using non-integrating vectors
Mesenchymal stromal cells (MSCs) have great value in cell therapies. The MSC therapies have many challenges due to its inconsistent potency and...
-
Extracellular vesicle-derived TP53BP1, CD34, and PBX1 from human peripheral blood serve as potential biomarkers for the assessment and prediction of vascular aging
BackgroundVascular aging is an important pathophysiological basis for the senescence of various organs and systems in the human body, and it is a...
-
Generation of Human iPSC from Small Volume Peripheral Blood Samples
The generation of induced pluripotent stem cells (iPSCs) from patients has opened new doors to gain insights into disease pathophysiology and...
-
A C-type lectin induces NLRP3 inflammasome activation via TLR4 interaction in human peripheral blood mononuclear cells
Lectins are a large group of proteins found in many snake venoms. BjcuL is a C-type lectin from Bothrops jararacussu snake venom that does not...
-
Reduced Peripheral Blood Mitochondrial DNA Copy Number as Identification Biomarker of Suspected Arsenic-Induced Liver Damage
Arsenic (As) can cause liver damage and liver cancer and is capable of seriously affecting human health. Therefore, it is important to identify...
-
Silencing Itch in human peripheral blood monocytes promotes their differentiation into osteoclasts
IntroductionTwo clinical case reports of humans with mutations in Itch reported distinct morphological defects such as stunted growth, macrocephaly,...
-
Single-cell RNA-seq map** of chicken peripheral blood leukocytes
BackgroundSingle-cell transcriptomics provides means to study cell populations at the level of individual cells. In leukocyte biology this approach...
-
Tobacco exposure, but not aging, shifts the frequency of peripheral blood B cell subpopulations
Several disturbances in T-cell mediated immunity have been described during aging, but immunosenescence of the B-cell compartment is less well...
-
Effect of IL-10-producing B cells in peripheral blood and tumor tissue on gastric cancer
BackgroundInterleukin (IL)-10-producing B (B10) cells are generated in response to signals from the tumor microenvironment and promote tumor growth...
-
Combined protein and transcript single-cell RNA sequencing in human peripheral blood mononuclear cells
BackgroundCryopreserved peripheral blood mononuclear cells (PBMCs) are frequently collected and provide disease- and treatment-relevant data in...
-
Sourcing of human peripheral blood-derived myeloid angiogenic cells under xeno-free conditions for the treatment of critical limb ischemia
BackgroundCritical limb ischemia (CLI) is the most severe form of peripheral artery disease and exhibits a high risk of lower extremity amputations....
-
Expression of Molecules Characterizing Metabolic and Cytotoxic Activity of Different Natural Killer Cell Subpopulations in Peripheral Blood during Pregnancy
AbstractThe functions of peripheral blood natural killer (NK) cells change significantly throughout pregnancy, which is mainly due to the inhibition...
-
Rapamycin restores peripheral blood flow in aged mice and in mouse models of atherosclerosis and Alzheimer’s disease
Peripheral artery disease (PAD), defined as reduced blood flow to the lower limbs, is a serious disorder that can lead to loss of function in the...
-
Age-related changes in energy metabolism in peripheral mononuclear blood cells (PBMCs) and the brains of cognitively healthy seniors
Mitochondrial dysfunction is a hallmark of cellular senescence and many age-related neurodegenerative diseases. We therefore investigated the...
-
Morfofunctional and Molecular Changes in Placenta and Peripheral Blood in Preeclampsia and Gestational Diabetes Mellitus
AbstractGestational diabetes mellitus (GDM) and preeclampsia (PE) are common pregnancy complications with similar risk factors. Although GDM is...
-
Age-associated polyamines in peripheral blood cells and plasma in 20 to 70 years of age subjects
Dietary polyamines have been associated with slowing ageing processes and various pathologies, raising the importance of establishing reference...
-
Autologous hematopoietic stem cell transplantation significantly alters circulating ceramides in peripheral blood of relapsing-remitting multiple sclerosis patients
BackgroundThe common inflammatory disease multiple sclerosis (MS) is a disease of the central nervous system. For more than 25 years autologous...
-
Histone crotonylation of peripheral blood mononuclear cells is a potential biomarker for diagnosis of colorectal cancer
BackgroundBlood-based tests have public appeal in screening cancers due to their minimally invasive nature, ability to integrate with other routine...
-
Central and Peripheral Fatigue
Skeletal muscle fatigue, characterized by a temporary decline in the ability to generate force or power output, encompasses peripheral and central...