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Synchronous force and Ca2+ measurements for repeated characterization of excitation-contraction coupling in human myocardium
Dysfunctional Ca 2+ signaling affects the myocardial systole and diastole, may trigger arrhythmia and cause transcriptomic and proteomic modifications...
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Speg interactions that regulate the stability of excitation-contraction coupling protein complexes in triads and dyads
Here we show that striated muscle preferentially expressed protein kinase α (Spegα) maintains cardiac function in hearts with Spegβ deficiency. Speg...
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Excitation-contraction coupling in skeletal muscle: recent progress and unanswered questions
Excitation-contraction coupling (ECC) is a physiological process that links excitation of muscles by the nervous system to their mechanical...
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Computational Modeling of Cardiac Electrophysiology
Mathematical modeling and simulation are well-established and powerful tools to integrate experimental data of individual components of cardiac...
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Biophysical reviews top five: voltage-dependent charge movement in nerve and muscle
The discovery of gating currents and asymmetric charge movement in the early 1970s represented a remarkable leap forward in our understanding of the...
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Effects of membrane cholesterol-targeting chemicals on skeletal muscle contractions evoked by direct and indirect stimulation
Cholesterol is one of the major components of plasma membrane, where its distribution is nonhomogeneous and it participates in lipid raft formation....
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Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution
Channel enzymes represent a class of ion channels with enzymatic activity directly or indirectly linked to their channel function. We investigated a...
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A GABAergic system in atrioventricular node pacemaker cells controls electrical conduction between the atria and ventricles
Physiologically, the atria contract first, followed by the ventricles, which is the prerequisite for normal blood circulation. The above phenomenon...
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The Impact of Chronic Magnesium Deficiency on Excitable Tissues—Translational Aspects
Neuromuscular excitability is a vital body function, and Mg 2+ is an essential regulatory cation for the function of excitable membranes. Loss of Mg 2+ ...
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Integrative Mathematical Model of Electrical, Metabolic and Mechanical Processes in Human Cardiomyocytes
AbstractA complex sequence of electrical and mechanical processes at different levels of the heart organization provides its pum** function. The...
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Mechanisms of weakness in Mdx muscle following in vivo eccentric contractions
Skeletal muscle of the dystrophin-deficient mdx mouse is hypersensitive to eccentric (ECC) contraction-induced strength loss due to plasmalemmal...
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Assessment of Cell Viability in Electrically Excitable Muscle Cells Through Intact Twitch Stimulation
Muscle cells (i.e. skeletal muscle fibers) are fully viable and functional when their excitation-contraction (EC) coupling machinery is intact. This...
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Effects of reduced muscle glycogen on excitation–contraction coupling in rat fast-twitch muscle: a glycogen removal study
The aim of this study was to investigate the effects of an enzymatic removal of glycogen on excitation–contraction coupling in mechanically skinned...
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Simultaneous triple-parametric optical map** of transmembrane potential, intracellular calcium and NADH for cardiac physiology assessment
Investigation of the complex relationships and dependencies of multiple cellular processes that govern cardiac physiology and pathophysiology...
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Mitochondrial Calcium Handling in Isolated Mitochondria from a Guinea Pig Heart
Mitochondrial calcium (Ca2+) plays a key role in regulating normal cardiac function. A physiological increase in mitochondrial matrix calcium [Ca2+]m...
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The Skeletal Muscle Calcium Channel
CaV1.1 is the voltage-gated calcium channel isoform uniquely expressed in skeletal muscle. Its primary function is that of the voltage sensor for...
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CaV1.3 channel clusters characterized by live-cell and isolated plasma membrane nanoscopy
A key player of excitable cells in the heart and brain is the L-type calcium channel Ca V 1.3. In the heart, it is required for voltage-dependent Ca 2+ -s...
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Is the fundamental pathology in Duchenne's muscular dystrophy caused by a failure of glycogenolysis–glycolysis in costameres?
Duchenne muscular dystrophy (DMD) is the most common form of progressive childhood muscular dystrophy associated with weakness of limbs, loss of...
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PKM2 deficiency exacerbates gram-negative sepsis-induced cardiomyopathy via disrupting cardiac calcium homeostasis
Sepsis is a life-threatening syndrome with multi-organ dysfunction in critical care medicine. With the occurrence of sepsis-induced cardiomyopathy...
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Organization of Ca2+ Signaling Microdomains in Cardiac Myocytes
Calcium signaling in cardiomyocytes regulates muscle contractile function and electrical signal propagation in the heart. While calcium influx in...