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Disruption of ER ion homeostasis maintained by an ER anion channel CLCC1 contributes to ALS-like pathologies
Although anion channel activities have been demonstrated in sarcoplasmic reticulum/endoplasmic reticulum (SR/ER), their molecular identities and...
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RU.521 mitigates subarachnoid hemorrhage-induced brain injury via regulating microglial polarization and neuroinflammation mediated by the cGAS/STING/NF-κB pathway
BackgroundThe poor prognosis of subarachnoid hemorrhage (SAH) is often attributed to neuroinflammation. The cGAS-STING axis, a cytoplasmic pathway...
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Effect of IgG Fc-fusion and KDEL-ER retention signal on prostate-specific antigen expression in plant and its immune in mice
Prostate-specific antigen (PSA) is a protein highly expressed in cancer cells of the prostate gland. In this study, the PSA recombinant protein was...
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Delivery of loaded MR1 monomer results in efficient ligand exchange to host MR1 and subsequent MR1T cell activation
MR1-restricted T cells have been implicated in microbial infections, sterile inflammation, wound healing and cancer. Similar to other antigen...
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NR4A1 enhances MKP7 expression to diminish JNK activation induced by ROS or ER-stress in pancreatic β cells for surviving
Under adverse conditions, such as sustained or chronic hyperglycemia or hyperlipidemia, ROS (reactive oxygen species) or/and ER-stress (endoplasmic...
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IL-33/ST2 antagonizes STING signal transduction via autophagy in response to acetaminophen-mediated toxicological immunity
BackgroundInterleukin-33 (IL-33), defined as "alarming", exert diverse functions through signaling via the suppression of tumorigenicity 2 (ST2)....
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Nanomedicine targeting ferroptosis to overcome anticancer therapeutic resistance
A potential reason for the failure of tumor therapies is treatment resistance. Resistance to chemotherapy, radiotherapy, and immunotherapy continues...
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Metabolic disorders sensitise endometrial carcinoma through endoplasmic reticulum stress
BackgroundMetabolic disorder is considered a well-established risk factor for endometrial carcinoma (EC). However, the mechanism remains unclear....
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Sophoridine derivative 6j inhibits liver cancer cell proliferation via ATF3 mediated ferroptosis
Liver cancer is one of the most lethal malignancies with an annual death of over 830,000 cases. Although targeted therapeutic drugs have achieved...
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Network pharmacology exploration reveals the bioactive compounds and molecular mechanisms of Li-Ru-Kang against hyperplasia of mammary gland
Li-Ru-Kang (LRK) has been commonly used in the treatment of hyperplasia of mammary gland (HMG) as a cipher prescription and achieved obvious...
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Breast Cancer Cells in 3D Model Alters Their Sensitivity to Hormonal and Growth Factors
AbstractThe purpose of this work was to study the formation and growth of mono- (3D) and heterogeneous (3D-2) spheroids composed of stromal and tumor...
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Nuclear soluble cGAS senses double-stranded DNA virus infection
The DNA sensor cGAS detects cytosolic DNA and instigates type I interferon (IFN) expression. Recent studies find that cGAS also localizes in the...
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Co-transient expression of PSA-Fc and PAP-Fc fusion protein in plant as prostate cancer vaccine candidates and immune responses in mice
Key messagePAP-FcK and PSA-FcK prostate cancer antigenic proteins transiently co-expressed in plant induce their specific humoral immune responses in...
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A review on the anti-parasitic activity of ruthenium compounds
BackgroundThere are many infectious diseases in the world caused by parasites. Among them, toxoplasmosis, American trypanosomiasis, African...
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Sorcin is an early marker of neurodegeneration, Ca2+ dysregulation and endoplasmic reticulum stress associated to neurodegenerative diseases
Dysregulation of calcium signaling is emerging as a key feature in the pathogenesis of neurodegenerative diseases such as Alzheimer’s disease (AD),...
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Overgrazing leads to decoupling of precipitation patterns and ecosystem carbon exchange in the desert steppe through changing community composition
Background and aimsUnderstanding the effects of grazing and precipitation pattern on ecosystem carbon (C) exchange, and their interactions is crucial...
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ERO1α mediates endoplasmic reticulum stress-induced apoptosis via microRNA-101/EZH2 axis in colon cancer RKO and HT-29 cells
Although colon cancer is a leading and typical gastrointestinal tumor, there is little published data on the underlying molecular mechanisms of...
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Integrated transcriptome and metabolome analysis revealed that HaMYB1 modulates anthocyanin accumulation to deepen sunflower flower color
Key messageHanMYB1 was found to play positive roles in the modulation of anthocyanins metabolism based on the integrative analysis of different color...
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The cGAS-STING pathway in cardiovascular diseases: from basic research to clinical perspectives
The cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) synthase-stimulator of interferon genes (cGAS-STING) signaling pathway, an...
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Bear trade in Poland: an analysis of legal and illegal international trade from 2000 to 2021
Commercial trade is one of the leading threats to bears as they are targeted for trophies, food and medicines. While the threat from illegal trade...
