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Enhancer selectivity in space and time: from enhancer–promoter interactions to promoter activation
The primary regulators of metazoan gene expression are enhancers, originally functionally defined as DNA sequences that can activate transcription at...
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Variable-Length Promoter Strength Prediction Based on Graph Convolution
Engineering promoters play a crucial role in cellular factory design by allowing specific engineering gene expression and regulating its expression...
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The Role of CTCF-Mediated Chromatin Loo** in Enhancer-Promoter Communication
In vertebrates, gene transcription is performed by generic eukaryotic molecular machinery under influence of sequence-specific DNA-binding...
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pCtFSG2, a flower-specific promoter with suitable promoter activity in safflower
Safflower ( Carthamus tincorius L.) is an economically important plant. Flowers are a source of dyes and active ingredients in medicines. The...
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Quantitative Estimation of Promoter Activity in Cannabis sativa Using Agroinfiltration-Based Transient Gene Expression
To properly assess promoter activity, which is critical for understanding biosynthetic pathways in different plant species, we use...
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The Mediator complex regulates enhancer-promoter interactions
Enhancer-mediated gene activation generally requires physical proximity between enhancers and their target gene promoters. However, the molecular...
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Core promoter mutation of nucleotides A1762T and G1764A of hepatitis B virus increases core promoter transactivation by hepatocyte nuclear factor 1
Hepatitis B virus (HBV) infection highly increases the risk for liver cirrhosis and hepatocellular carcinoma (HCC). The clinical manifestation of HBV...
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An efficient CRISPR–Cas12a promoter editing system for crop improvement
Promoter editing represents an innovative approach to introduce quantitative trait variation (QTV) in crops. However, an efficient promoter editing...
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Identification of a sugarcane bacilliform virus promoter that is activated by drought stress in plants
Sugarcane ( Saccharum spp.) is an important sugar and biofuel crop in the world. It is frequently subjected to drought stress, thus causing...
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Promoter evolution of mammalian gene duplicates
BackgroundGene duplication is thought to be a central process in evolution to gain new functions. The factors that dictate gene retention following...
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Functional analysis of recurrent CDC20 promoter variants in human melanoma
Small nucleotide variants in non-coding regions of the genome can alter transcriptional regulation, leading to changes in gene expression which can...
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Develo** a CRISPR/FrCas9 system for core promoter editing in rice
Small mutations in the core promoter region of a gene may result in substantial changes in expression strengths. However, targeting TA-rich sequences...
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Dual-Luciferase Reporter Assay for Prescreening CRISPR (d)Cas9-Mediated Epigenetic Editing on a Plant Promoter Using Human Cells
Epigenetic editing, also known as EpiEdit, offers an exciting way to control gene expression without altering the DNA sequence. In this study, we...
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Cellular reprogramming is driven by widespread rewiring of promoter-enhancer interactions
BackgroundLong-range interactions between promoters and cis -regulatory elements, such as enhancers, play critical roles in gene regulation. However,...
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New pAraDH2 Promoter for Metabolic Engineering of the Yarrowia lipolytica Yeast
AbstractThe ability to utilize a number of polyhydric alcohols as a sole carbon source has been studied in the Yarrowia lipolytica yeast. The...
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Synthetic sub-genomic transcript promoter from Horseradish Latent Virus (HRLV)
Main conclusionWe characterized an efficient chimeric sub-genomic transcript promoter from Horseradish Latent Virus, FHS4, active in both dicot and...
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Human Heme Oxygenase-1 Promoter Activity Is Mediated by Z-DNA Formation
In recent years, it has been shown that Z-DNA formation in DNA plays functionally significant roles in nucleic acid metabolism, such as gene...
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DNA methyltransferase 3a-induced hypermethylation of the fructose-1,6-bisphosphatase-2 promoter contributes to gastric carcinogenesis
BackgroundAberrant DNA methylation has been implicated in the development of gastric cancer (GC). In our previous study, we demonstrated that...
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DNMT1/DNMT3a-mediated promoter hypermethylation and transcription activation of ICAM5 augments thyroid carcinoma progression
Promoter methylation is one of the most studied epigenetic modifications and it is highly relevant to the onset and progression of thyroid carcinoma...
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HDAC1/2/3 are major histone desuccinylases critical for promoter desuccinylation
Lysine succinylation is one of the major post-translational modifications occurring on histones and is believed to have significant roles in...
