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Schizosaccharomyces pombe comparative genomics; from sequence to systems
The fission yeast Schizosaccharomyces pombe is becoming increasingly important as a model for the characterization and study of many globally...
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Telomeres in fungi
Telomeres are the functional elements concluding and defining each linear chromosome in eukaryotes. They play an essential role in protecting genetic...
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Comparative genomics and gene finding in fungi -- Supplement
Online Supplement to Chapter 1
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The genome of the filamentous fungus Ashbya gossypii: annotation and evolutionary implications
The 9.2 Mb genome of the filamentous fungus Ashbya gossypii consists of seven chromosomes carrying 4718 protein coding genes, 194 tRNA genes, at...
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S. cerevisiae K28 toxin – a secreted virus toxin of the A/B family of protein toxins
Since the initial discovery of toxin-secreting killer strains in the yeast Saccharomyces cerevisiae more than 40 years ago, continuous research on...
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Cholera toxin: mechanisms of entry into host cells
Cholera toxin moves from the plasma membrane to the ER of host cells to cause disease. Trafficking in this pathway depends on toxin binding to...
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The Ustilago maydis killer toxins
Killer toxins are small proteins secreted by a number of fungi that are lethal to susceptible cells (generally fungi of the same or related species)....
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Diphtheria toxin, diphtheria-related fusion protein toxins, and the molecular mechanism of their action against eukaryotic cells
Diphtheria toxin remains one of the most successfully studied of the bacterial protein toxins. A detailed understanding of the structure function...
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Taxonomy and phylogenetic diversity among the yeasts
Yeasts are among the economically and scientifically most important eukaryotic microorganisms known. At present, there are 1,500 recognized species,...
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Genome evolution: Lessons from Genolevures
In the past years, yeast genome-sequencing programs have been widely developed. Two of them, namely Genolevures I and II, were devoted to the...
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Structural features of fungal genomes
Eighteen fungal genomes have been sequenced to date from a variety of taxonomic groups, with fifteen Ascomycota, two Basidomycota and one...
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Comparative genomics and gene finding in fungi
In the spring of 2005, we had access to 18 fully sequenced fungal genomes, and more are coming rapidly. New approaches and methods are being...
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Zygocin – a monomeric protein toxin secreted by virus-infected Zygosaccharomyces bailii
Zygocin, a protein toxin secreted by virus-infected strains of the osmotolerant spoilage yeast Zygosaccharomyces bailii kills a broad spectrum of...
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Acidophilic structure and killing mechanism of the Pichia farinosa killer toxin SMKT
SMKT, a killer toxin produced by a halotolerant yeast Pichia farinosa that consists of α and β subunits, is generated from a chromosomally encoded...
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Lager brewing yeast
Lager brewing yeast is a group of closely related strains of Saccharomyces pastorianus/S. carlsbergensis used for lager beer production all over the...
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Ricin: structure, synthesis, and mode of action
Ricin is a lectin produced by the seeds of the Ricinus communis plant. It is potently toxic to mammalian cells, where it acts to inhibit the...
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Employing protein size in the functional analysis of orthologous proteins, as illustrated with the yeast HOG pathway
Comparative genomics has provided us with a new handle on the interpretation of protein sequences. The sequencing of numerous fungal genomes has...
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ExoU: A cytotoxin delivered by the type III secretion system of Pseudomonas aeruginosa
ExoU is a potent cytotoxin that is injected into host cells by the type III secretion system of Pseudomonas aeruginosa. It has recently been shown to...
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Anthrax toxin and genetic aspects regulating its expression
Anthrax toxin is a unique, tripartite bacterial toxin, capable of causing edema and lethality through binary combinations of protective antigen (PA)...
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Duplication of genes and genomes in yeasts
The molecular evolution of the group of yeasts closely related to Saccharomyces cerevisiae has been profoundly affected by an ancient polyploidy...