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Ikaros sets the threshold for negative B-cell selection by regulation of the signaling strength of the AKT pathway
Inhibitory phosphatases, such as the inositol-5-phosphatase SHIP1 could potentially contribute to B-cell acute lymphoblastic leukemia (B-ALL) by...
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Uncovering the role of ferroptosis in Bietti crystalline dystrophy and potential therapeutic strategies
PurposeBietti crystalline dystrophy (BCD) is an inherited retinal degeneration disease caused by mutations in the CYP4V2 gene. Currently, there is...
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Role of O-linked N-acetylglucosamine protein modification in oxidative stress-induced autophagy: a novel target for bone remodeling
O-linked N-acetylglucosamine protein modification (O-GlcNAcylation) is a dynamic post-translational modification (PTM) involving the covalent binding...
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Macrophage-derived exosomes promote telomere fragility and senescence in tubular epithelial cells by delivering miR-155
BackgroundChronic kidney disease (CKD) is highly prevalent worldwide, and its global burden is substantial and growing. CKD displays a number of...
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Hypoxic extracellular vesicles from hiPSCs protect cardiomyocytes from oxidative damage by transferring antioxidant proteins and enhancing Akt/Erk/NRF2 signaling
BackgroundStem cell-derived extracellular vesicles (EVs) are an emerging class of therapeutics with excellent biocompatibility, bioactivity and...
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Ningetinib, a novel FLT3 inhibitor, overcomes secondary drug resistance in acute myeloid leukemia
BackgroundFMS-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) is a common mutation type in acute myeloid leukemia (AML) and is usually...
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tRF-His-GTG-1 enhances NETs formation and interferon-α production in lupus by extracellular vesicle
BackgroundHyperactive neutrophil extracellular traps (NETs) formation plays a crucial role in active severe systemic lupus erythematosus (SLE)....
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Hainanenin-1, an oncolytic peptide, triggers immunogenic cell death via STING activation in triple-negative breast cancer
BackgroundIn triple-negative breast cancer (TNBC) therapy, insufficient tumor infiltration by lymphocytes significantly hinders the efficacy of...
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The crosstalk between copper-induced oxidative stress and cuproptosis: a novel potential anticancer paradigm
Copper is a crucial trace element that plays a role in various pathophysiological processes in the human body. Copper also acts as a transition metal...
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Tonabersat suppresses priming/activation of the NOD-like receptor protein-3 (NLRP3) inflammasome and decreases renal tubular epithelial-to-macrophage crosstalk in a model of diabetic kidney disease
BackgroundAccompanied by activation of the NOD-like receptor protein 3 (NLRP3) inflammasome, aberrant connexin 43 (Cx43) hemichannel-mediated ATP...
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SARS-CoV-2-associated lymphopenia: possible mechanisms and the role of CD147
T lymphocytes play a primary role in the adaptive antiviral immunity. Both lymphocytosis and lymphopenia were found to be associated with severe...
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Context-dependent T-BOX transcription factor family: from biology to targeted therapy
T-BOX factors belong to an evolutionarily conserved family of transcription factors. T-BOX factors not only play key roles in growth and development...
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TonEBP inhibits ciliogenesis by controlling aurora kinase A and regulating centriolar satellite integrity
BackgroundPrimary cilia on the surface of eukaryotic cells serve as sensory antennas for the reception and transmission in various cell signaling...
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Role of liver sinusoidal endothelial cell in metabolic dysfunction-associated fatty liver disease
Liver sinusoidal endothelial cells (LSECs) are highly specialized endothelial cells that represent the interface between blood cells on one side and...
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Tudor-SN promotes cardiomyocyte proliferation and neonatal heart regeneration through regulating the phosphorylation of YAP
BackgroundThe neonatal mammalian heart exhibits considerable regenerative potential following injury through cardiomyocyte proliferation, whereas...
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piRNA associates with immune diseases
PIWI-interacting RNA (piRNA) is the most abundant small non-coding RNA in animal cells, typically 26–31 nucleotides in length and it binds with PIWI...
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The RNA binding protein IGF2BP2/IMP2 alters the cargo of cancer cell-derived extracellular vesicles supporting tumor-associated macrophages
BackgroundTumor cells release extracellular vesicles (EVs) that contribute to the polarization of macrophages towards tumor-associated macrophages...
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Short-term response of primary human meniscus cells to simulated microgravity
BackgroundMechanical unloading of the knee articular cartilage results in cartilage matrix atrophy, signifying the osteoarthritic-inductive potential...
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Mechanisms underlying neutrophils adhesion to triple-negative breast cancer cells via CD11b-ICAM1 in promoting breast cancer progression
BackgroundTriple-negative breast cancer (TNBC) is recognized as the most aggressive and immunologically infiltrated subtype of breast cancer. A high...
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Identification of the central role of RNA polymerase mitochondrial for angiogenesis
Mitochondria are central to endothelial cell activation and angiogenesis, with the RNA polymerase mitochondrial (POLRMT) serving as a key protein in...
