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Gametic Embryogenesis in Triticum: a Study of Some Critical Factors in Haploid (Microspore) Embryogenesis
This review of embryogenesis from microspores in two types of wheat examines the influences of various procedures used to induce and produce...
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The Roles of Chromatin Remodelling Factors in Replication
Dynamic changes of chromatin structure control DNA-dependent events, including DNA replication. Along with DNA, chromatin organization must be...
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Structure and Function of Protein Modules in Chromatin Biology
Chromatin-mediated gene transcription or silencing is a dynamic process in which binding of various proteins or protein complexes can displace...
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Comparative genomics and gene finding in fungi
In the spring of 2005, we had access to 18 fully sequenced fungal genomes, and more are coming rapidly. New approaches and methods are being...
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Zygocin – a monomeric protein toxin secreted by virus-infected Zygosaccharomyces bailii
Zygocin, a protein toxin secreted by virus-infected strains of the osmotolerant spoilage yeast Zygosaccharomyces bailii kills a broad spectrum of...
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Acidophilic structure and killing mechanism of the Pichia farinosa killer toxin SMKT
SMKT, a killer toxin produced by a halotolerant yeast Pichia farinosa that consists of α and β subunits, is generated from a chromosomally encoded...
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Mechanisms and functions of RNA-guided RNA modification
RNA-guided 2’-O-methylations and pseudouridylations occur in several different types of RNAs and in a wide range of organisms. Hundreds of the RNAs...
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Role of the 5’-cap in the biogenesis of spliceosomal snRNPs
The biogenesis of spliceosomal UsnRNPs in higher eukaryotes involves a nucleocytoplasmic shuttling cycle. After transcription and processing in the...
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Um34 in selenocysteine tRNA is required for the expression of stress-related selenoproteins in mammals
Selenium is an essential micronutrient in the diet of mammals and has many health benefits. Selenium-containing proteins are responsible for most, if...
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Modelling signalling pathways – a yeast approach
MAP kinase pathways are conserved signalling systems in eukaryotes that control stress responses, cell growth, and proliferation, as well as...
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G1 Phase: Components, Conundrums, Context
A eukaryotic cell must coordinate DNA synthesis and chromosomal segregation to generate a faithful replica of itself. These events are confined to...
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Metabolic flux analysis: A key methodology for systems biology of metabolism
Genome-wide analyses of mRNA, protein, or metabolite complements of biological systems produce unprecedented data sets. In contrast to such cellular...
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The ubiquitin-proteasome pathway in cell cycle control
Ubiquitin-mediated proteolysis is one of the key mechanisms underlying cell cycle control. The removal of barriers posed by accumulation of...
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Mechanistic and modular approaches to modeling and inference of cellular regulatory networks
In this chapter we wish to present a vision of systems biology as a discipline that generates new insight and knowledge with quantitative and...
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Chaperone proteins and peroxisomal protein import
Peroxisomes are ubiquitous organelles present in most eukaryotic cells. Their role in cellular metabolism is diverse among species. An array of genes...
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Mathematical modelling of the Wnt-pathway
A kinetic model of the Wnt-signal transduction pathway is presented which includes the main molecular components of this system. It is based on a set...
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Systems Biology: Did we know it all along?
It is often suggested that Systems Biology is nothing new, or that it is irrelevant. Its central paradigm, i.e. that much of biological function...
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Protein Kinases Involved in Mitotic Spindle Checkpoint Regulation
A number of checkpoint controls function to preserve the genome by restraining cell cycle progression until prerequisite events have been properly...
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Regulation of SNARE assembly by protein phosphorylation
Protein phosphorylation is emerging as an important regulatory mechanism that controls the secretory pathway. It enables coupling between the...
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Molecular mechanisms in clathrin-mediated membrane budding
Clathrin-coated vesicles (CCVs) form at the plasma membrane where they select cargo for endocytic entry into cells. CCVs also form at the trans-Golgi...