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Degradation and Preservation of Organic Matter in Marine Sediments
Organic matter that is deposited in aquatic sediments is subject to an intense diagenetic reactor that determines how much organic carbon is...
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The Retinoblastoma Gene Family in Cell Cycle Regulation and Suppression of Tumorigenesis
Since its discovery in 1986, as the first tumor suppressor gene, the retinoblastoma gene (Rb) has been extensively studied. Numerous biochemical and...
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Senescence and Cell Cycle Control
In response to various stresses, such as telomere shortening during continuous proliferation, oxidative stress, DNA damage and aberrant oncogene...
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Control of Cell Proliferation and Growth by Myc Proteins
Myc proteins act as signal transducers that alter cell proliferation in dependence on signals from the extracellular environment. In normal cells,...
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Checkpoint and Coordinated Cellular Responses to DNA Damage
The DNA damage and replication checkpoints are signaling mechanisms that regulate and coordinate cellular responses to genotoxic conditions. The...
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Regulation of S Phase
Regulation of DNA replication is critical for accurate and timely dissemination of genomic material to daughter cells. The cell uses a variety of...
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Mouse Models of Cell Cycle Regulators: New Paradigms
In yeast, a single cyclin-dependent kinase (Cdk) is able to regulate diverse cell cycle transitions (S and M phases) by associating with multiple...
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Biological Markers for Anoxia in the Photic Zone of the Water Column
In this chapter we review the current state of knowledge on the occurrence of anoxic conditions in the water column of past depositional systems...
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Controls on the Carbon Isotopic Compositions of Lipids in Marine Environments
Organic carbon isotopes have long been used to study modern and ancient biogeochemical processes. Controls on the isotopic composition of organic...
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Sources and Cycling of Organic Matter in the Marine Water Column
The organic carbon cycle operates on multiple time scales with a only small fraction of the global reservoir actively exchanged. For the marine...
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Molecular Tools for the Analysis of DNA in Marine Environments
In the last decade, microbial ecologists have increasingly applied molecular techniques to investigate microorganisms in natural environments. The...
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Atmospheric Transport of Terrestrial Organic Matter to the Sea
The transport of atmospheric particles with associated terrestrial organic matter to the oceans is an important process affecting various global...
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G1 Phase: Components, Conundrums, Context
A eukaryotic cell must coordinate DNA synthesis and chromosomal segregation to generate a faithful replica of itself. These events are confined to...
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The ubiquitin-proteasome pathway in cell cycle control
Ubiquitin-mediated proteolysis is one of the key mechanisms underlying cell cycle control. The removal of barriers posed by accumulation of...
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Protein Kinases Involved in Mitotic Spindle Checkpoint Regulation
A number of checkpoint controls function to preserve the genome by restraining cell cycle progression until prerequisite events have been properly...
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Modeling Cell Cycle Control and Cancer with pRB Tumor Suppressor
Cancer is a complex syndrome of diseases characterized by the increased abundance of cells that disrupts the normal tissue architecture within...
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The Centrosome Cycle
Centrosomes are dynamic organelles involved in many aspects of cell function and growth. Centrosomes act as microtubule organizing centers, and...
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Sources and Fate of Organic Contaminants in the Marine Environment
The sources, levels, and fate of organic contaminants of major concern in the marine environment are reviewed. Spatial distributions among the...
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Lipid Markers for Marine Organic Matter
An astonishing variety of different lipids have been found in marine sediments and the water column attesting to the diversity of biosynthetic...
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Pigment Markers for Phytoplankton Production
Chlorophylls and carotenoids are commonly used as quantitative biomarkers for the composition and biomass of marine phytoplankton. This chapter...