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Systems biology of the yeast cell cycle engine
One goal of systems biology is to obtain an integrated understanding of the physiological properties of cells from the detailed molecular machinery...
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A modular systems biology analysis of cell cycle entrance into S-phase
A modular systems biology approach to the study of the cell cycle of the budding yeast Saccharomyces cerevisiae is presented. Literature on the...
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Catalysis by Enzyme Conformational Change
An energy decomposition scheme is presented to elucidate the importance of the change of protein conformation substates to the reduction of...
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Tethering proteins in membrane traffic
In eukaryotic cells, protein secretion and the transport of materials between membrane-bounded organelles require efficient and accurate delivery of...
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Ricin: structure, synthesis, and mode of action
Ricin is a lectin produced by the seeds of the Ricinus communis plant. It is potently toxic to mammalian cells, where it acts to inhibit the...
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Translational Recoding and RNA Modifications
During protein synthesis, codons in mRNA are translated sequentially in frame on the ribosome following strict decoding rules. This process is...
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Modification and editing of RNA: historical overview and important facts to remember
RNA plays a central role in many cellular processes and several peculiarities of RNAs are probably relics of an ancient primordial RNA World. To...
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Role of a conserved pseudouridine in U2 snRNA on the structural and electrostatic features of the spliceosomal pre-mRNA branch site
A pseudouridine (ψ) residue in a phylogenetically conserved position of U2 snRNA that pairs with the intron to form the pre-mRNA branch site helix of...
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What is systems biology? From genes to function and back
The essence of the grand contributions of physiology and molecular biology to biology is discussed in relation to what may be needed to understand...
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Modeling the E. coli cell: The need for computing, cooperation, and consortia
Escherichia coli K-12 is an ideal test bed for pushing forward the limits of our ability to understand cellular systems through computational...
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Insight into the Catalytic Mechanism of Orotidine 5′-phosphate Decarboxylase from Crystallography and Mutagenesis
With a half-time of 78 million years at room temperature, the spontaneous decarboxylation of orotidine 5′-phosphate (OMP) is among the slowest...
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Regulation of exocytotic events by centrosome-analogous structures
Centrosomes, spindle pole bodies, and related structures, generally termed microtubule organising centres (MTOCs; Pickett-Heaps 1969), are best...
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10 Sphingosine-1-phosphate metabolism in mammalian cell signalling
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite implicated in the regulation of vital biological processes. Ample evidence...
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8 Biosynthesis and compartmentation of triacylglycerol in higher plants
The biosynthesis of storage lipids (triacylglycerols) in higher plants is now known to occur via a number of different routes. These include the...
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Introduction: Lipids: cellular glue...or are they more than that?
Some 40 years ago, there was a rumor in the research community that lipids are the stuff you have to throw away before starting biochemical...
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9 Mechanisms and mediators of neutral lipid biosynthesis in eukaryotic cells
The reactions leading to the biosynthesis of neutral lipids are excellent targets for therapeutic intervention in several disease states including...
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3 Biogenesis and cellular dynamics of glycerophospholipids in the yeast Saccharomyces cerevisiae
In the yeast Saccharomyces cerevisiae, as in other eukaryotes, glycerophospholipids are important cellular components required for growth and cell...
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4 Defects in cholesterol biosynthesis
Defects in eight different enzymes of cholesterol biosynthesis that result in serious clinical consequences have been identified. Most of these were...
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ExoU: A cytotoxin delivered by the type III secretion system of Pseudomonas aeruginosa
ExoU is a potent cytotoxin that is injected into host cells by the type III secretion system of Pseudomonas aeruginosa. It has recently been shown to...
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Anthrax toxin and genetic aspects regulating its expression
Anthrax toxin is a unique, tripartite bacterial toxin, capable of causing edema and lethality through binary combinations of protective antigen (PA)...